Mortality Among Hardmetal Production Workers

McElvenny, Damien; MacCalman, Laura; Sleeuwenhoek, Anne; Davis, Alice; Miller, Brian G.; Alexander, Carla; Cowie, Hilary; Cherrie, John W.; Kennedy, Kathleen; Esmen, Nurtan A.; Zimmerman, Sherri A.; Buchanich, Jeanine M.; Marsh, Gary M.

doi:10.1097/jom.0000000000001036

Cited by 12 publications

(1 citation statement)

References 15 publications

(14 reference statements)

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“…The human cancer evidence for cobalt without tungsten carbide remained “inadequate.” Studies (funded by the International Tungsten Industry Association) reported findings for lung cancer among hardmetal workers in Austria, 52 Germany, 53 Sweden, 54 the UK, 55 and the United States, 56 including in a pooled study. 57 Elevated lung cancer mortality rates were seen in comparison with national rates for short-term workers but, for long-term workers, they were seen only among women.…”

Section: Discussionmentioning

confidence: 99%

Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned

Turner,

Cogliano,

Guyton

et al. 2023

Environ Health Perspect

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Background: The International Agency for Research on Cancer (IARC) Monographs program assembles expert working groups who publish a critical review and evaluation of data on agents of interest. These comprehensive reviews provide a unique opportunity to identify research needs to address classification uncertainties. A multidisciplinary expert review and workshop held in 2009 identified research gaps and needs for 20 priority occupational chemicals, metals, dusts, and physical agents, with the goal of stimulating advances in epidemiological studies of cancer and carcinogen mechanisms. Overarching issues were also described. Objectives: In this commentary we review the current status of the evidence for the 20 priority agents identified in 2009. We examine whether identified Research Recommendations for each agent were addressed and their potential impact on resolving classification uncertainties. Methods: We reviewed the IARC classifications of each of the 20 priority agents and identified major new epidemiological and human mechanistic studies published since the last evaluation. Information sources were either the published Monograph for agents that have been reevaluated or, for agents not yet reevaluated, Advisory Group reports and literature searches. Findings are described in view of recent methodological developments in Monographs evidence evaluation processes. Discussion: The majority of the 20 priority agents were reevaluated by IARC since 2009. The overall carcinogen classifications of 9 agents advanced, and new cancer sites with either “sufficient” or “limited” evidence of carcinogenicity were also identified for 9 agents. Examination of published findings revealed whether evidence gaps and Research Recommendations have been addressed and highlighted remaining uncertainties. During the past decade, new research addressed a range of the 2009 recommendations and supported updated classifications for priority agents. This supports future efforts to systematically apply findings of Monograph reviews to identify research gaps and priorities relevant to evaluation criteria established in the updated IARC Monograph Preamble. https://doi.org/10.1289/EHP12547

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Section: Discussionmentioning

confidence: 99%

Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned

Turner,

Cogliano,

Guyton

et al. 2023

Environ Health Perspect

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Tungsten

Olalde,

Venezia

2023

Patty's Toxicology

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Tungsten is a rare metal with numerous applications, most notably in machine tools, catalysts, and superalloys. The physical and chemical properties of tungsten and its compounds of commercial importance (such as sodium tungstate, ammonium meta ‐ and para ‐tungstate, tungsten metal, tungsten carbide, and tungsten oxides), as well as tungsten industrialization, recycling, occupational exposure, and biomonitoring are discussed. Between 1970 and 1990, most tungsten toxicological investigations concerned the toxicity and health effects of cemented carbides, also known as hard metal, rather than tungsten and its compounds themselves. However, within the last decade a diversity of studies on the toxicity of the water soluble and bioavailable sodium tungstate, have been conducted to fill several toxicity knowledge gaps. Acute toxicity studies on several soluble (sodium tungstate, ammonium para ‐ and meta ‐tungstate) and sparingly water‐soluble (tungsten metal, tungsten oxides, tungsten carbide) substances reported low acute oral, dermal, and inhalation toxicity, as well as a lack of eye and dermal irritation and sensitization potential. Studies published within the last 5–7 years on sodium tungstate include oral repeated exposure, reproductive, developmental, neurotoxicological, and immunotoxicological endpoints. Several reports have incorrectly associated repeated exposure toxicity of hard metals with pure tungsten carbide. As the toxicity of hard metal does not represent the intrinsic toxicity of tungsten substances so it is discussed separately within this chapter.

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Risk of bladder, kidney and prostate cancer from occupational exposure to welding fumes: a systematic review and meta-analysis

Collatuzzo,

Hamdani,

Boffetta

2024

Int Arch Occup Environ Health

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Mortality Among Hardmetal Production Workers

Abstract: In this small study, there is no evidence to support that working in the UK hardmetal manufacturing industry increased mortality from any cause including lung cancer.

Cited by 12 publications

References 15 publications

Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned

Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned

Tungsten

Risk of bladder, kidney and prostate cancer from occupational exposure to welding fumes: a systematic review and meta-analysis

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