Comparative study using fractional carbon dioxide laser versus glycolic acid peel in treatment of pseudo-acanthosis nigricans

Zaki, Naglaa Sameh; Hilal, Rana F; Essam, R. M.

doi:10.1007/s10103-018-2505-x

Cited by 18 publications

(32 citation statements)

References 13 publications

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“…Texture was mild in 5% and 5%, moderate in 15% and 25% and extremely coarse in 80% and 70% on right and left sides respectively (p: 0.842). This comes in accordance with Zaki et al (9) study who demonstrated that all patients had similar, however not identical, degree of severity for both sides (right and left) before treatment (P value = 0.99).…”

Section: Discussionsupporting

confidence: 92%

“…All cases were females and mean age was 17.5 ranging from 6 to 39 years. Female preponderance was reported by Zaki et al (9) , Eldeeb et al (13) and Leerapongnan et al (12) studies. Conversely, Thomas et al (14) study has shown that AN is more prevalent in the male population [55 were male (55%) and the rest 45 were female (45%)].…”

Section: Discussionmentioning

confidence: 72%

“…First coat of the peeling was applied and the frosting was observed; if no frosting formed, a second coat was applied. Sodium bicarbonate was applied to neutralize the peeling effect, and emollient was advised for patient for 1 week after peeling (9) .…”

Section: All Patients Were Subjected Tomentioning

confidence: 99%

“…Fractional laser improves both the pigmentary and textural changes by removing thin layers of skin with minimal thermal damage leading to dermal wound and new collagen formation, which is the primary mechanism behind the improvement seen after laser resurfacing and the undamaged normal surrounding skin, is a reservoir allowing rapid epidermal repair (9) .…”

Section: Introductionmentioning

confidence: 99%

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Fractional Carbon Dioxide Laser versus Glycolic Acid Peel in Treatment of Pseudo-Acanthosis Nigricans

State¹,

Elsayed²,

Mohammed³

2021

The Egyptian Journal of Hospital Medicine

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Background: Acanthosis nigricans (AN) is a common cutaneous condition that can be a manifestation of systemic disease. AN is characterized by hyperpigmented and hyperkeratotic velvety skin lesions that presents mainly on the flexural sites, for example, the neck, the axillae, and groin. Objective: The aim of this study was to evaluate the clinical efficacy of fractional carbon dioxide laser versus glycolic acid peel 70% in treatment of pseudo-acanthosis nigricans through assessing changes in degree of area index, severity and texture of lesion. Patients and methods: Twenty patients with pseudo-acanthosis nigricans were included in this study. They were chosen from the Outpatient Clinic of Dermatology, Andrology & STDs department, Mansoura University Hospitals. All cases were subjected to fractional CO2 laser on the right side of the neck and glycolic acid peel 70% on the left side of the neck. Each patient was followed up for 3 and half months. Results: There was statistically significant difference regarding improvement in area index, severity and texture across time subjected to glycolic acid (GA) peeling 70%. There was statistically significant difference regarding improvement in area index, severity and texture across time subjected to fractional CO2 laser. There was no statistically significant difference when comparing effect of laser and peeling on adult and children. There was no statistically significant difference when comparing effect of laser and peeling on rural and urban cases. Conclusion:Acanthosis nigricans is a difficult dermatosis to treat, although there are many methods of treatment. Glycolic acid peeling 70% and fractional CO2 laser are considered effective modalities for AN treatment. However, GA peeling was more effective but statically insignificant.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 72%

Section: All Patients Were Subjected Tomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fractional Carbon Dioxide Laser versus Glycolic Acid Peel in Treatment of Pseudo-Acanthosis Nigricans

State¹,

Elsayed²,

Mohammed³

2021

The Egyptian Journal of Hospital Medicine

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“…However, clinical improvement on the side treated by glycolic acid peel showed 43% improvement while the side treated by fractional CO 2 showed 19% improvement. It was concluded that fractional CO 2 laser is inferior to glycolic acid peeling 83 …”

Section: Systemic Treatmentsmentioning

confidence: 99%

Acanthosis nigricans: A review

Das

Datta²,

Kassir

et al. 2020

J of Cosmetic Dermatology

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Background Acanthosis nigricans (AN) is a cutaneous disorder characterized by symmetric velvety hyperpigmented plaques on intertriginous areas like axilla, neck, inframammary, and groin. Aims To summarize the pathophysiology and classification of AN, provide an update of diagnostic testing strategies, and describe the current therapeutic options described so far in the literature for this disease. Methods A comprehensive english language literature search across multiple databases (PubMed, EMBASE, MEDLINE, and Cochrane) for keywords (alone and in combination) was performed. MeSH as well as non‐MeSH terms such as “acanthosis nigricans,” “classification,” “pathophysiology,” “diagnosis,” “treatment,” “topical drugs,” “systemic drugs,” “chemical peeling,” and “lasers” were taken into consideration. Results The pathophysiology of AN revolves around a multifactorial stimulation of proliferation of epidermal keratinocytes and dermal fibroblasts. Various types of AN include benign, obesity‐associated, syndromic, malignant, acral, unilateral, medication‐induced, and mixed‐type. Homeostasis model assessment‐insulin resistance (HOMA‐IR) is a good tool for assessment of insulin resistance. Management involves general measures (weight reduction and addressing the underlying cause, if any), topical drugs (retinoids, vitamin D analogs, and keratolytics), oral drugs (retinoids and insulin sensitizers), chemical peels (trichloroacetic acid), and lasers (Long pulsed alexandrite, fractional 1550‐nm erbium fiber, and CO2). Conclusion Acanthosis nigricans is a treatable condition; however, complete cure and disappearance of lesions are difficult to achieve. Weight reduction is the most scientific and practical management strategy. Long‐term studies and further research is warranted in the pathophysiology and treatment of this common condition.

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Metabolic Syndrome: Dermatological Aspects in Women

Mintoff¹,

Das²

2022

Skin Diseases in Females

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Comparative study using fractional carbon dioxide laser versus glycolic acid peel in treatment of pseudo-acanthosis nigricans

Cited by 18 publications

References 13 publications

Fractional Carbon Dioxide Laser versus Glycolic Acid Peel in Treatment of Pseudo-Acanthosis Nigricans

Fractional Carbon Dioxide Laser versus Glycolic Acid Peel in Treatment of Pseudo-Acanthosis Nigricans

Acanthosis nigricans: A review

Metabolic Syndrome: Dermatological Aspects in Women

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