Comparative study on the thermal behavior of two similar triterpenes from birch

Anghel, Mariana; Vlase, Gabriela; Bilanin, Mihai; Albu, Paul; Fuliaş, Adriana; Tolan, Iolanda; Doca, N.

doi:10.1007/s10973-013-3203-3

Cited by 21 publications

(6 citation statements)

References 23 publications

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“…Therefore, great similarity was observed in its structure, whereas the major part is composed of cyclic chains. Two intense bands at 1450 cm −1 and 1375 cm −1 were observed and are related to the bending vibrations of the C-H bond of methyl and methylene groups, respectively [ 13 , 14 ].…”

Section: Resultsmentioning

confidence: 99%

Physicochemical Characterization and Biological Activities of the Triterpenic Mixture α,β-Amyrenone

et al. 2017

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α-Amyrenone and β-amyrenone are triterpenoid isomers that occur naturally in very low concentrations in several oleoresins from Brazilian Amazon species of Protium (Burseraceae). This mixture can also be synthesized by oxidation of α,β-amyrins, obtained as major compounds from the same oleoresins. Using a very simple, high yield procedure, and using a readily commercially available mixture of α,β-amyrins as substrate, the binary compound α,β-amyrenone was synthesized and submitted to physico-chemical characterization using different techniques such as high-performance liquid chromatography, nuclear magnetic resonance (1H and 13C), mass spectrometry, scanning electron microscopy, differential scanning calorimetry, thermogravimetry and derivative thermogravimetry, and Fourier transform infrared spectroscopy (FTIR). Biological effects were also evaluated by studying the inhibition of enzymes involved in the carbohydrate and lipid absorption process, such as α-amylase, α-glucosidase, lipase, and their inhibitory concentration values of 50% of activity (IC50) were also determined. α,β-Amyrenone significantly inhibited α-glucosidase (96.5% ± 0.52%) at a concentration of 1.6 g/mL. α,β-Amyrenone, at a concentration of 100 µg/mL, showed an inhibition rate on lipase with an IC50 value of 82.99% ± 1.51%. The substances have thus shown in vitro inhibitory effects on the enzymes lipase, α-glucosidase, and α-amylase. These findings demonstrate the potential of α,β-amyrenone for the development of drugs in the treatment of chronic metabolic diseases.

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Section: Resultsmentioning

confidence: 99%

Physicochemical Characterization and Biological Activities of the Triterpenic Mixture α,β-Amyrenone

et al. 2017

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“…The importance of thermal analysis and spectroscopic description of pharmaceuticals [16][17][18][19] and potential bioactive derivatives [20][21][22][23], as well as in screening the cocrystal formation [24,25], is revealed by already published results. Following these considerations, we aimed in this study to obtain and characterize a new pharmaceutical cocrystal containing CBZ as active pharmaceutical ingredient and SA as coformer by the means of TG/DTG/HF techniques, FTIR spectroscopy and PXRD data.…”

Section: Introductionmentioning

confidence: 99%

Screening and characterization of cocrystal formation between carbamazepine and succinic acid

Fuliaş

Vlase

Suta

et al. 2015

J Therm Anal Calorim

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The pharmaceutical cocrystals are nowadays studied due to the fact that several properties, such as solubility, stability, dissolution rate and bioavailability, can be modulated. In this work, a cocrystal containing carbamazepine (CBZ) and succinic acid (SA) were prepared by the cogrinding method of the active substances, following the subjection of the physical mixture to microwave irradiation. The formation and stability of CBZ-SA cocrystal were explored using thermoanalytical methods (TG/ DTG/HF), Fourier transform infrared spectroscopy and PXRD pattern diffraction. The preparation of the cocrystal was realized by slow evaporation of solvent (ethanol) from the mixture which contained the active substances in molar ratio CBZ:SA = 2:1.

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“…The thermodynamic properties of materials are important for kinetic study. In the analysis, only three to five different heating rates obtained from TG and different kinetic analysis methods can provide believable kinetic study result [41]. Pyrolysis of nature biomass is too complex to understand during the thermal degradation, as a result, the exact reaction mechanism of biomass is impossible to demonstrate.…”

Section: Methodsmentioning

confidence: 99%

Chemical Property Changes and Thermal Analysis during the Carbonizing Process of the Pollen Grains of Typha

et al. 2018

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Carbonized pollen grains of Typha (CPT) were widely used in clinical for antithrombosis, wound and bleeding in China. In order to ensure the role of drugs, it is very important to control the quality of drugs. However, there is a lack of monitoring methods in the process of charcoal preparation. To characterize the process of CPT, we used thermal analysis, scanning electron microscope (SEM), color measurement, Fourier transform infrared spectrometry (FTIR) and HPLC. In this study, 7 min was the optimal processing time and the heating process condition should be controlled under 272.35 ± 7.23 °C. This comprehensive strategy to depict the whole carbonizing process would provide new ideas for researches on quality control of Traditional Chinese Medicine (TCM) and processing theory of charcoal medicine.

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Comparative study on the thermal behavior of two similar triterpenes from birch

Cited by 21 publications

References 23 publications

Physicochemical Characterization and Biological Activities of the Triterpenic Mixture α,β-Amyrenone

Physicochemical Characterization and Biological Activities of the Triterpenic Mixture α,β-Amyrenone

Screening and characterization of cocrystal formation between carbamazepine and succinic acid

Chemical Property Changes and Thermal Analysis during the Carbonizing Process of the Pollen Grains of Typha

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