Comparative study on the sedative effects of morphine, methadone, butorphanol or tramadol, in combination with acepromazine, in dogs

Monteiro, Eduardo Raposo; Rodrigues, André Figueiredo; Assis, Hemir Martins Quirilos; Campagnol, Daniela; Quitzan, Juliany Gomes

doi:10.1111/j.1467-2995.2008.00424.x

Cited by 119 publications

(128 citation statements)

References 27 publications

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“…In group M, no changes in the degree of resistance to examinations before and after sedation were observed. MONTEIRO et al (2009) observed moderate to intense sedation after the use of acepromazine and butorphanol in dogs, similar to the findings observed in the present study.…”

Section: Resultssupporting

confidence: 82%

Electrocardiographic, echocardiographic, and indirect blood pressure evaluation in dogs subjected to different sedation protocols

et al. 2016

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The present study aimed to evaluate the effects of different sedation protocols on blood pressure and echocardiographic and electrocardiographic parameters in dogs. In total, 24 male mixed-breed dogs with a mean weight of 9.87±3.0kg were used.Animals were randomly divided into four groups (n=6), which were subjected to sedation using the following protocols: acepromazine (0.05mgkg -1 ) and butorphanol (0.3mgkg -1

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Section: Resultssupporting

confidence: 82%

Electrocardiographic, echocardiographic, and indirect blood pressure evaluation in dogs subjected to different sedation protocols

et al. 2016

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“…Credie et al (2010) reported bradycardia, sinus arrest, and ventricular escape rhythm when methadone was used, corroborating with cardiac depression and arrhythmias observed in the present study. However, studies using tramadol have reported no clinical complications (Mastrocinque and Fantoni, 2003;Monteiro et al, 2009) and the different results observed in this study were probably due to the high intensity of the surgical pain stimuli, which promotes the release of catecholamine (Desborough, 2005).…”

Section: Discussionmentioning

confidence: 56%

“…This effect may be attributed to the wide action of methadone on the nociceptive pathway, giving it superior antinociceptive potency and duration (Gourlay et al 1982;Sarrau et al, 2007), thus leading to a more effective block of central sensitization (Dyson, 2008;Gottschalk et al, 2011). The propofol sparring effect observed in the MET group (20%) has been described for other opioids (Short and Bufalari 1999;Covey-Crump and Murison 2008;Kaur et al, 2013) and for the methadone/ dexmedetomidine association (Canfrán et al, 2016) and can be attributed to the strong sedative effect of methadone on dogs (Monteiro et al, 2009), which was not observed when tramadol was used. However, the sedation in these animals was not evaluated and is a limiting factor in the present study.…”

Section: Discussionmentioning

confidence: 81%

“…The HR was significantly higher and MAP lower in the TRA group compared to the MET group at time 10 (anaesthetic stabilization) and the values were considered outside normal clinical ranges (MAP < 65 mmHg and HR > 120 bpm), concluding that animals experienced clinical hypotension and reflex tachycardia. This could be due to the higher PID used in this group (6.9 ± 1.2 mg/Kg) as propofol causes a dose-dependent hypotensive effect (Branson, 2007) in addition to the hypotensive effect related to the high doses of tramadol (≥ 5 mg/Kg) administered, causing an increased release of nitric oxide in the vascular endothelium (Raimundo et al, 2008;Monteiro et al, 2009). On the other hand, the MET group exhibited significantly higher MAP at certain times (10, 70, 90, 100 min) and lower HR (non-significant 10 to 50 min) than the TRA group.…”

Section: Discussionmentioning

confidence: 99%

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Pre-emptive methadone or tramadol analgesia for mastectomy and ovariohysterectomy in bitches

Uscategui

Tiosso

Moro

et al. 2017

Rev Colomb Cienc Pecu

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Analgesia preventiva con tramadol o metadona para mastectomia y ovario histerectomía en perrasAnalgesia preventiva com tramadol ou metadona para mastectomia e ováriohisterectomia em cadelas Abstract Background: mastectomy and ovariohysterectomy (OVH) in bitches are critical surgeries and pain control can be challenging. Objective: to evaluate the efficacy of pre-emptive analgesia with methadone (MET) or tramadol (TRA) in postoperative pain intensity, cardiorespiratory effects, and anaesthetic/analgesic consumption in female dogs undergoing mastectomy and OVH. Methods: a prospective randomized blind clinical trial was used to evaluate 48 bitches of various breeds, aged 10 ± 3.7 years, weighing 16 ± 12 Kg, and with multiple mammary tumours. The animals were distributed in two groups: TRA group received 5 mg/Kg tramadol and MET group 0.5 mg/Kg methadone intramuscularly, 10 min prior to anaesthesia induction with propofol followed by maintenance with isoflurane. Heart (HR) and respiratory (RR) rates, mean arterial pressure (MAP), propofol induction dose (PID), oxyhemoglobin saturation (SpO 2 ), end-tidal isoflurane concentration (EtISO), and carbon dioxide pressure (EtCO 2 ) were measured during the intra-operative period. Post-operative pain was evaluated for 12 h and rated according to the Melbourne scale. Rescue analgesia (0.5 mg/Kg methadone, 2 mg/Kg lidocaine, or 0.01 mg/Kg/min ketamine IV) was given when necessary and post-operative analgesic consumption recorded. Statistical tests were used to compare treatments. Results: rescue analgesia requirements, pain score, PID and analgesic consumption were significantly lower (p<0.05) in MET group. The HR was higher in TRA group, while EtCO 2 and MAP were higher in MET group (p<0.05). Conclusion: methadone was more effective than tramadol in pre-emptive analgesia but not completely adequate on controlling pain in bitches subjected to

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“…Among their main adverse effects, respiratory depression with reduction in minute volume (JAFFE; MARTIN, 1991), increased partial pressure of carbon dioxide, and acidosis (THURMON et al, 1996) stand out, as well as cardiovascular changes, hypotension, premature ventricular contractions, and bradycardia (GUEDES et al, 2006;MONTEIRO et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Cardiorespiratory and electrocardiographic effects of methadone or morphine in the perioperative period in anesthetized dogs with continuous rate infusion of propofol and submitted to ovariohysterectomy

Cintra

Duque

Silveira

et al. 2017

SCA

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Cardiorespiratory and electrocardiographic effects of methadone or morphine in the perioperative period in anesthetized dogs with continuous rate infusion of propofol and submitted to ovariohysterectomyEfeitos cardiorrespiratórios e eletrocardiográficos da metadona ou morfina no período perioperatório em cães anestesiados com infusão contínua de propofol e submetidos a ovário-histerectomia AbstractThe aims of this study were compare the electrocardiogram (ECG) and cardiopulmonary effects of methadone or morphine, both injected intravenously (IV) in dogs anesthetized with continuous infusion of propofol. Sixteen healthy female mongrel dogs were used in this study for elective ovariohysterectomy. The animals were allocated in random order into two groups assigned GME (methadone 0.3 mg kg -1 , IV) or GMO (morphine 0.3 mg kg -1 , IV). Parameters were evaluated: heart rate (HR), P-wave amplitude (Ps and PmV), interval between Ps and R waves (PR), QRS duration (QRS), R-wave amplitude (R), duration the interval between the Q and T waves (QT), systolic blood pressure (SBP), rectal temperature (RT), respiratory rate (RR), end tidal of carbon dioxide (ETCO 2 ) and periferic oxyhemoglobin saturation (SpO 2 ). Postoperative analgesia was assessed by mechanical nociceptive stimulus based on the scale proposed by Firth and Haldane (1999) and rescue analgesia based on the visual analogue scale. HR was lower in GME in relation to GMO. The P, PmV, PR, QRS, R and QT values remained within their normality tracks, showing no clinical importance. Apnea and ETCO 2 increased in both groups. There was no difference between groups of the analgesic effects. It can be concluded that methadone and morphine promote similar cardiovascular effects after IV injection during surgery in dogs anesthetized with propofol by continuous rate infusion, however, when methadone used, assisted ventilation is required. In addition, both drugs promote postoperative analgesia until six hours. ResumoO presente estudo teve como objetivo comparar as alterações no eletrocardiograma (ECG) e nos parâmetros cardiorrespiratórios da metadona ou morfina administrada pela via intravenosa (I.V.) em cães anestesiados com infusão intravenosa contínua de propofol. Foram utilizados 16 cadelas, sem raça definida submetidos ao procedimento de ovário-histerectomia. Os animais foram distribuídos aleatoriamente em dois grupos, designados como GME (metadona 0,3 mg kg -1 , I.V.) ou GMO (morfina 0,3 mg kg -1 , I.V.). Os parâmetros avaliados foram frequência cardíaca (FC), tempo e amplitude da onda P (Ps e PmV), intervalo entre as ondas P e R (PR), duração do complexo QRS (QRS), amplitude da onda R (R), duração do intervalo entre as ondas Q e T (QT), pressão arterial sistólica (PAS), temperatura retal (TR), frequência respiratória (f), tensão de dióxido de carbono no final da expiração (ETCO 2 ) e saturação de oxigênio na hemoglobina (SpO 2 ). A analgesia pós-operatória foi verificada seguindo a proposta de Firth e Haldane (1999) e o regaste analgésico baseado na escala análoga v...

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Comparative study on the sedative effects of morphine, methadone, butorphanol or tramadol, in combination with acepromazine, in dogs

Cited by 119 publications

References 27 publications

Electrocardiographic, echocardiographic, and indirect blood pressure evaluation in dogs subjected to different sedation protocols

Electrocardiographic, echocardiographic, and indirect blood pressure evaluation in dogs subjected to different sedation protocols

Pre-emptive methadone or tramadol analgesia for mastectomy and ovariohysterectomy in bitches

Cardiorespiratory and electrocardiographic effects of methadone or morphine in the perioperative period in anesthetized dogs with continuous rate infusion of propofol and submitted to ovariohysterectomy

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