Comparative study on the efficacy of Allium sativum (garlic) in reducing some heavy metal accumulation in liver of wistar rats

Nwokocha, Chukwuemeka R.; Owu, Daniel U.; Nwokocha, Magdalene; Ufearo, CS; Iwuala, M. O. E.

doi:10.1016/j.fct.2011.11.003

Cited by 48 publications

(41 citation statements)

References 35 publications

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“…Animal studies showed that though both ascorbic acid and heated garlic juice were effi cient in preventing cadmium-induced damage in the rat liver, ascorbic acid appeared to be a more powerful antioxidant than heated garlic juice in preventing cadmium-induced oxidative damage in liver, and its action may be mediated in parts via the Nrf2-Keap1 pathway (Lawal et al 2011 ). Nwokocha et al ( 2012 ) found that administration of raw garlic to rat chow offered more hepatoprotective effect to cadmium (200 ppm) followed by mercury (10 ppm) and the least protection to lead (100 ppm) administered in the drinking water to rats.…”

Section: Hepatoprotective Activitymentioning

confidence: 98%

Allium sativum

Lim¹

2014

Edible Medicinal and Non Medicinal Plants

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Section: Hepatoprotective Activitymentioning

confidence: 98%

Allium sativum

Lim¹

2014

Edible Medicinal and Non Medicinal Plants

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“…[6] Reports on the increasing role and usefulness of medicinal plant products in maintenance and optimization of health have led to research on the efficacy of these medicinal plants/nutrient products’ effects on the amelioration of the metal-induced toxicity. [910111213] These plant products are reported to affect the bioavailability, transport, and toxico-dynamics of this metal in the tissues.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of the effect of some nutritional medicinal plants effect on lead accumulation in the liver following different modes of administration

et al. 2014

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Context and Objectives:Lead (Pb) toxicity leads to cell damage in many organs of the body. Using different treatment interventions and modes of administration we comparatively examined the protective ability of some medicinal plants on liver Pb accumulation.Materials and Methods:Rats were fed on either 7% w/w Zingiber officinale, 7% w/w Allium sativum, 10% w/w Lycopersicon esculentum, 5%, w/w Garcinia kola (all in rat chow), while Pb (100 ppm) was given in drinking water. The additives were administered together with (mode 1), a week after exposure to (mode 2) or a week before metal exposure to (mode 3) the metal for a period of 6 weeks. The metal accumulations in the liver were determined using atomic absorption spectrometry and compared using analysis of variance.Results:Some additives significantly (P < 0.05) reduced, while others enhanced Pb accumulation. Mode 2 yielded the highest mean % protection and mode 3 the lowest, no significant interaction between modes of administration and time of measurement in their relationships to percentage protection, but there was statistically significant (P < 0.05) interaction between modes of administration and additive used in their relationships to percentage protection.Conclusion:Protective effects of medicinal plants are varied and depend on the nature of lead exposure.

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“…Herbal remedies are known to affect the dynamics of drug and chemical interactions (Nwokocha et al, 2011(Nwokocha et al, , 2012 and these enzymes are of significant concern to drug-drug interactions.…”

Section: +mentioning

confidence: 99%