Comparative Study on the Antifungal Activity of Some Di- and Tributyltin(IV) Carboxylate Compounds

Abstract

A series of di-and tributyltin(IV) carboxylate compounds prepared by reacting the dibutyltin(IV) dichloride and tributyltin(IV) chloride respectively via the organotin(IV) oxide with the respective carboxylic acids have been tested for antifungal activity against Fusarium oxysporum and Aspergillus niger in potatoes dextrose agar. The compounds synthesized were mainly characterized with IR and UV-Vis spectroscopies as well as based on the microanalytical data. The results showed that di-and tributyltin(IV) carboxylates prepared in general exhibit greater fungitoxicity than the organotin chlorides, the intermediate products and the free carboxylic acids. The organotin moiety plays an important role in deciding the antifungal activity of an organotin compound indeed true in our respect that the antifungal activity of tributyltin(IV) carboxylates is more active than dibutyltin(IV) carboxylates .

<i>IN VITRO</i> ACTIVITY AND COMPARATIVE STUDIES OF SOME ORGANOTIN(IV) BENZOATE DERIVATIVES AGAINST LEUKEMIA CANCER CELL, L-1210

“…As an example in the spectrum of 1, this bond appeared at frequency of 334.2 cm and the symmetric stretch at ca. 1600 cm -1 , confirming the success of the substitution reaction [9,[11][12].…”

“…To maximize the product (6) and [(C 6 H 5 ) 3 SnOH] (10) respectively similar to those previously reported [9,[11][12]. The reaction occurred in each step for dibutyltin(IV) dicarboxylates, for example, is shown in Scheme 1.…”

“…The organotin(IV) carboxylates used in this work and similar compounds with variety of benzoic derivatives as the ligands were prepared based on the procedure previously reported [9,[11][12], and was adapted from the work by Szorcsik et al [13]. An example procedure in the preparation of dibutyltin(IV) dibenzoate is as follows:…”

“…The antifungal activity of diorganotin(IV) and triorganotin(IV) compounds are well known, and many of their compounds have been synthesized for that purpose [6,[10][11][12]. Some of the organotin(IV) compounds prepared have also been tested for antitumor activity and showed quite high antitumor activity [1,3,[7][8][9].…”

“…The current investigations on the coordinating properties of carboxylates toward organotin compounds have led to the isolation of some new organotin(IV) carboxylates and carboxylate derivatives which have shown some interesting biological activities such as antimicrobial [5][6], antitumor and anticancer [1,3,[7][8][9], and antifungal activity [6,[10][11][12]. The investigation of organotin(IV) as possible antitumor compound has been and is still attracting much attention [1,3,[7][8][9].…”