Comparative study on bone regeneration by synthetic octacalcium phosphate with various granule sizes

Effect of β tricalcium phosphate particle size on recombinant human platelet-derived growth factor-BB-induced regeneration of periodontal tissue in dog

“…An increase in the number of interparticular spaces between β-TCP particles would provide an increased number of sites which cells could infiltrate 30) . In this study, L-TCP(O) particles yielded greater enhancement of new bone formation than S-TCP(G) particles.…”

“…Furthermore, TRAP-positive osteoclastic cells remained significantly longer on L-TCP(O) particles than on S-TCP(G) particles. In general, an increase in the surface area of biodegradable materials with decreased particle size would facilitate their dissolution by surrounding tissue fluids 30) . In the present experiment, we expected that S-TCP(G)-sized β-TCP particles would accelerate dissolution, resulting in significantly greater enhancement of new bone tissue regeneration than that obtainable with L-TCP(O) particles.…”

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

“…Although OCP has not been observed in vascular calcifications, it has been strongly suggested as a precursor phase to biological apatite found in natural and prosthetic heart valves (Tomazic et al 1994;Nancollas and Wu 2000). In surgery, OCP is used for implantation into bone defects (Suzuki et al 2006;Kikawa et al 2009;Murakami et al 2010;Suzuki 2013). For the comprehensive information on OCP, the readers are referred to other reviews (Suzuki 2010a;Chow and Eanes 2001;Suzuki 2013).…”

Effect of grain size and microporosity on the in vivo behaviour of β-tricalcium phosphate scaffolds

“…Intensive efforts have been made to determine the most adequate composition and architecture. On the chemical side, many materials varying in composition and architecture have been proposed, including polymers (Ishaug-Riley et al, 1997;Ignatius et al, 2001;Mondrinos et al, 2006;Gogolewski et al, 2008), metals (Ayers et al, 1999;Bobyn et al, 1999;Itala et al, 2001;Witte et al, 2007) and ceramics (Klawitter and Hulbert, 1971;Klein et al, 1985;van Blitterswijk et al, 1986;Eggli et al, 1988;Daculsi and Passuti, 1990;Schliephake et al, 1991;Basle et al, 1993;Metsger et al, 1993;Lu et al, 1999;Flautre et al, 2001;Walsh et al, 2003;Jones and Hench, 2004;Linhart et al, 2004;Hench, 2006;Von Doernberg et al, 2006;Lan Levengood et al, 2010;Murakami et al, 2010;Yuan et al, 2010;Polak et al, 2011;Haugen et al, 2013). These materials present very different resorption rates, and many resorption mechanisms, such as dissolution, hydrolysis (e.g., poly(α-hydroxy acids) (Ignatius et al, 2001)), cell-mediated resorption (Basle et al, 1993;Lu et al, 1999;Von Doernberg et al, 2006;Yuan et al, 2010), corrosion (Witte et al, 2007), enzymatic degradation (Hutmacher, 2000;Vert, 2007), and transport <...>…”