Comparative study of the clinical picture and histopathologic structure of oral leukoplakia

Bánóczy, J; Csiba, A

doi:10.1002/1097-0142(197205)29:5<1230::aid-cncr2820290515>3.0.co;2-3

Cited by 57 publications

(13 citation statements)

References 8 publications

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“…Oral leukoplakia legends PG Arduino et al of the studies results and the variable methodologies used. Collectively, the majority of studies have shown no conclusive association between tobacco and OLs (Banoczy and Csiba, 1976;Hogewind and van der Waal, 1988;Saito et al, 1995;Silverman and Gorsky, 1997;Schepman et al, 1998;Napier and Speight, 2008;Goldstein et al, 2010). Alcohol abuse and the association with OSCC have been strongly established (Bagnardi et al, 2001;Pelucchi et al, 2008;Goldstein et al, 2010), and the extent of consumption was found to be the strongest determinant of risk (Pelucchi et al, 2008).…”

Section: Oral Diseasesmentioning

confidence: 99%

Urban legends series: oral leukoplakia

et al. 2013

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To date, the term oral leukoplakia (OL) should be used to recognize 'predominantly white plaques of questionable risk, having excluded (other) known diseases or disorders that carry no increased risk of cancer'. In this review, we addressed four controversial topics regarding oral leukoplakias (OLs): (i) Do tobacco and alcohol cause OLs?, (ii) What percentage of OLs transform into oral squamous cell carcinoma (OSCC)?, (iii) Can we distinguish between premalignant and innocent OLs?, and (iv) Is proliferative verrucous leukoplakia (PVL) a specific entity or just a form of multifocal leukoplakia? Results of extensive literature search suggest that (i) no definitive evidence for direct causal relationship between smoked tobacco and alcohol as causative factors of OLs, (ii and iii) the vast majority of OLs follow a benign course and do not progress into a cancer, and no widely accepted and/or validated clinical and/or biological factors can predict malignant transformation, and (iv) the distinction between multifocal/multiple leukoplakias and PVL in their early presentation is impossible; the temporal clinical progression and the high rate of recurrences and development of cancer of PVL are the most reliable features for diagnosis.

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Section: Oral Diseasesmentioning

confidence: 99%

Urban legends series: oral leukoplakia

et al. 2013

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“…In the assessment of epithelial dysplasia, an increase in nuclear-cytoplasmic (N/C) ratio has been cited (5,6,(33)(34)(35)(36)(37) as one of the features most likely to predict transformation of a precancerous lesion to squamous cell carcinoma. The N/C ratio lends itself readily to morphometric analysis.…”

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confidence: 99%

Preliminary assessment of the epithelial nuclear‐cytoplasmic ratio and nuclear volume density in human palatal lesions

Jin

Yang

White

1995

J Oral Pathology Medicine

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We have analysed both the nuclear-cytoplasmic (N/C) ratio and nuclear volume densities (VVN) in defined strata from human hard palate lesions with and without malignant potential to determine the prognostic reliability and/or validity of this parameter. Measurements of cellular and nuclear areas of basal and spinous cells from normal (N) and pathological palatal epithelium were made on histological sections using an image analyser. The lesions comprised fibrous hyperplasia (FH), traumatic inflammation (INF), benign hyperkeratosis (HK), squamous cell papilloma (PP), dysplastic epithelium adjacent to invasive carcinoma (CE) and islands of invasive squamous cell carcinoma (CI). In basal cells, no significant differences were detected in comparisons of N/C and VVN between all pathological groups and the N control group. The mean value for CE was lower than that obtained for N. In spinous cells, the only statistically significant comparison was between IF and FH for both N/C and VVN. Both parameters were lower in CE than in N. Of all groups analysed except CI, the CE group is the only one likely to possess an increased malignant potential. The N/C ratio therefore seems to be of no value as a predictor of malignancy in palatal epithelial lesions.

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“…The percentage of cases of oral leukoplakia that develop into carcinoma was calculated as 12% in a study of 312 cases by Sturgis and Lund, 7 13.2% in a study of 500 cases by Bánóczy and Csiba, 8 11.1% in a study of 56 cases by Mincer and associates, 9 but only 2.7% in a study of 331 cases by Roed‐Peterson 10 . A follow‐up of 600 cases of oral leukoplakia diagnosed in our laboratory has shown a 5% development of carcinoma within 10 years 11…”

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confidence: 99%