Comparative study of the acquisition of antibody to Norwalk virus in pediatric populations

Cukor, George; Blacklow, Neil R.; Echeverria, Peter; Bedigian, M K; Puruggan, H; Basaca-Sevilla, V

doi:10.1128/iai.29.2.822-823.1980

Cited by 35 publications

References 15 publications

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Prevalence of antibodies to human caliciviruses (HuCVs) in Kuwait established by ELISA using baculovirus-expressed capsid antigens representing two genogroups of HuCVs

et al. 1997

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Baculovirus recombinant-expressed antigens of Norwalk viruses (rNV) and a Mexico strain (rMX) of the Snow Mountain serogroup of human caliciviruses (HuCVs) were used in enzyme immunoassays to study the antibody prevalence among the Kuwaiti population and foreign workers employed in Kuwait. The antibody titers in 16 different age groups which ranged from neonates to centenarians were investigated by testing eight different dilutions of each serum (1:200-1:25,600). The results indicate that NV infection is widespread in Kuwait and affects all age groups Ninety-eight percent of the 433 serum samples tested had antibodies to rNV. In the 50-79-year, old age group, the antibody levels to rNV were higher and significantly different from those in children 0-7 years old. In infants, the rNV antibodies did not diminish by 4 months of age and their titer steadily increased with age. When 414 of these sera samples were tested for antibodies to rMX, 96% positive serological responses were observed. Antibody titers to rMX were reduced in infants from 4 to 11 months; however, 95% of the samples were positive. These data indicate that children born in Kuwait are infected with Norwalk-like viruses at a very early age. Finally, antibodies to rNV and rMX were found in 98% of 151 and in 95% of 148 foreign workers, respectively.

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Prevalence of antibodies to human caliciviruses (HuCVs) in Kuwait established by ELISA using baculovirus-expressed capsid antigens representing two genogroups of HuCVs

et al. 1997

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Seroprevalence and seroincidence of Norwalk-like virus infection among Brazilian infants and children

Talal

Moe

Lima³

et al. 2000

J. Med. Virol.

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To determine the importance of Norwalk-like viruses (NLVs) as pediatric pathogens in a developing country, the seroprevalence and seroincidence of this group of viruses in a cohort of children less than 4 years of age in an urban shantytown in northeastern Brazil was examined. Serum samples were collected approximately every 6 months from 135 children who were surveyed three times each week for diarrhea and vomiting. NLV IgG was measured by an enzyme immunosorbent assay (EIA) with recombinant Norwalk virus capsid protein. Overall NLV seroprevalence was 71%, and the overall NLV seroconversion rate was 0.7 seroconversions per child-year. The highest age-specific NLV seroconversion rate (0.8 seroconversions per child-year) was observed in the 13-24-month age group. For all study children, the incidence of diarrhea and vomiting was significantly greater (P < 0.01) during time periods spanned by serum pairs that indicated NLV seroconversion compared with time periods without NLV seroconversion. However, NLV seroconversion was not associated with gastrointestinal symptoms during the first year of life.

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Norwalk‐Like Viruses: Detection Methodologies and Environmental Fate

Meschke

Sobsey

2003

Encyclopedia of Environmental Microbiology

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Comparative study of the acquisition of antibody to Norwalk virus in pediatric populations

Abstract: Analysis by radioimmunoassay of pediatric sera from three populations showed that antibody to Norwalk virus is acquired at a significantly earlier age in a less developed and tropical area (Philippines) than in two more developed and nontropical countries (United States and Taiwan).

Cited by 35 publications

References 15 publications

Prevalence of antibodies to human caliciviruses (HuCVs) in Kuwait established by ELISA using baculovirus-expressed capsid antigens representing two genogroups of HuCVs

Prevalence of antibodies to human caliciviruses (HuCVs) in Kuwait established by ELISA using baculovirus-expressed capsid antigens representing two genogroups of HuCVs

Seroprevalence and seroincidence of Norwalk-like virus infection among Brazilian infants and children

Norwalk‐Like Viruses: Detection Methodologies and Environmental Fate

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