1986
DOI: 10.1128/aac.29.2.379
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Comparative study of serum bactericidal activity of cefotaxime alone or in combination with tobramycin

Abstract: The objectives of this study were to investigate the bactericidal activity in serum of cefotaxime alone or in combination with tobramycin against clinical strains and to determine the influence of tobramycin on the pharmacokinetics of cefotaxime. The The bactericidal activity test in serum has been recommended to monitor antimicrobial therapy in patients with serious infections. It is generally agreed upon that a bactericidal activity in serum of >1:8 correlates with the clinical effectiveness of antibiotics… Show more

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