Comparative study of salivary pH and volume in adults with chronic laryngopharyngitis by gastroesophageal reflux disease before and after treatment

Abstract

These findings suggest that salivary pH and volume are influenced by the presence of gastroesophageal contents and that salivary pH monitoring can potentially become a cost-effective method for diagnosing and controlling LPR.

Loss of Alkalization in Proximal Esophagus: a New Diagnostic Paradigm for Patients with Laryngopharyngeal Reflux

“…Using failure to maintain alkalinization in the cervical esophagus in the diagnosis of LPR is also consistent with recent studies that show a reduction in salivary pH in LPR patients when compared to normal individuals without LPR, and a positive correlation has been shown between the presence of the laryngopharyngeal symptoms and a reduction in salivary volume. 27,28 Although we have shown that sensitivity can be improved by adding the assessment of percent time pH≥7 to dual probe monitoring, further studies will be needed to determine whether the overall accuracy is affected. In clinical practice, enhanced sensitivity often comes at the expense of reduced specificity.…”

Proton pump inhibitor-associated pneumonia: Not a breath of fresh air after all?

“…Twenty three patients with either GERD or larygnopharyngeal reflux were enrolled in a 12 wk study to assess the change in the salivary pH when administered omeprazole 20 mg twice daily by mouth. Prior to beginning therapy, the average salivary pH was 7.15, but this increased to 7.58 following 12 wk of therapy [42] . Although this was a statistically significant increase in pH, the physiological pH of salivary acid is generally about 8.0.…”

“…A study conducted by Eckley [42] took this concept one step further. Twenty three patients with either GERD or larygnopharyngeal reflux were enrolled in a 12 wk study to assess the change in the salivary pH when administered omeprazole 20 mg twice daily by mouth.…”

A potentiometric disposable sensor strip for measuring pH in saliva

“…Accessible body fluids such as saliva represent an interesting medium for the realization of body-sensing, as these fluids also contain important personal physiological information [13][14][15][16][17][18][19][20]. Continuous monitoring of pH in saliva would be extremely beneficial for maintaining healthy mouth conditions, e.g., degradation of tooth enamel [21] and detection of Gastroesophageal Reflux Disease (GERD) [22][23][24], as well as drug activity, as in some cases this can depend on saliva pH [17].…”