Comparative study of photodegradation of three hematoporphyrin derivative: Photofrin®, Photogem®, and Photosan®

Ferreira, Juliana; Menezes, Priscila Fernanda Campos de; Kurachi, Cristina; Sibata, C; Allison, Ron R.; Bagnato, V. S.

doi:10.1002/lapl.200710058

Cited by 34 publications

(21 citation statements)

References 39 publications

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“…Photodegradation of the macrocycle in H 2 Por has usually been attributed to oxygen-mediated reactions that may be prompted due to absorption of photonic energy by both the porphyrin substrate and molecular oxygen. Since excited porphyrins may sensitize O 2 species to give rise to the formation of singlet molecular oxygen ( 1 D g ) along with some other radicals, it is frequently referred to as the principal reason for the photo-bleaching of porphyrins [39][40][41][42]. Hence, it is important to assess the stability range for the most promising porphyrin systems, including their protonated forms.…”

Section: Coomentioning

confidence: 99%

meso-Aryl-substituted free-base porphyrins: formation, structure and photostability of diprotonated species

et al. 2015

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Susceptibility to interact with trifluoroacetic acid (TFA) of selected freebase porphyrins, including a novel lipophilic 3-n-pentadecyl(phenoxy)-ethoxyphenyl-substituted porphyrin, and photostability of their diprotonated compounds was explored in benzene and N,N-dimethylformamide (DMF). Results have been discussed in terms of the commonly applied pK a -based procedure and confronted with a simple approach derived from experimentally-determined correlations reflecting the porphyrins affinity for TFA. Density functional theory (DFT) has proved the porphyrin moiety creates stable diprotonated species involving two TFA molecules, in which the fluorine atoms effectively contribute to the overall interaction of the acid with the porphyrin macrocycle. The relevance of the mesosubstituent and ambient medium to the reactivity and photostability of diverse porphyrin derivatives was emphasized and referred to structural features of the investigated diprotonated porphyrins.

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Section: Coomentioning

confidence: 99%

meso-Aryl-substituted free-base porphyrins: formation, structure and photostability of diprotonated species

et al. 2015

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“…4) [18]. The largest absorption band around 370 nm corresponds to a Soret band, while the other four lower bands correspond to Q-bands, with absorption at 507, 540, 570, 620 nm.…”

Section: Photostability Of Photogem ®mentioning

confidence: 98%

“…The number of chikungunya cases increased 600% in 2015 in comparison to 2014, as approximately 18,000 cases were notified [8]. Infections by Zika virus reached around 18 Brazilian states in 2015 and caused population to be on alert due to their relationship with outbreaks of microcephaly, which hit mainly the Northeastern region.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Photogem® (Hematoporphyrin Derivative) as a Photoactivatable Larvicide against Aedes aegypti (Diptera: Culicidae) Larvae

Souza¹,

Inada²,

Pratavieira³

et al. 2017

JLS

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Dengue vector is responsible for millions of deaths every year and has caused disastrous impacts on health systems. The continuous use of chemical insecticides, such as carbamates, pyrethroids and organophosphates generates resistant populations of the mosquito, therefore, new control methods must be investigated. The joint action of the population and guidelines for preventing the reproduction of the mosquito associated with the use of photoactivatable insecticides can be the alternative for the control of epidemiological outbreaks in affected regions. In this study, the photo-larvicidal activity of Photogem ® (PG), a derivative of hematoporphyrin, was investigated against 2 nd -early 3 rd instar of Aedes aegypti larvae (Diptera: Culicidae) under different lighting conditions (artificial lighting system and sunlight). The dynamics of PG accumulation was characterized by CLSM (confocal laser scanning microscopy) and total time PG eliminationin solution was investigated by ultraviolet-visible spectrophotometry. The maximum photo-activity of PG was observed in 0.5 h under sunlight exposure which achieved 100% larval mortality. Fluorescence images showed a uniform distribution of PG along the digestive tract. PG remained stable in the sunlight for 48 h and in an artificial lighting system for longer periods, therefore, it can be used for the control of Aedes aegypti larvae as a new alternative to chemical insecticides. The method is considered environmentally friendly due to its rapid degradation in the presence of light. Further studies are required, so that the potential of the technique can be explored in real breeding places.

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“…Currently, in PDT there is an important concept associated with a model of light-tissue interaction, the amount of cell toxicity, and cell death, called threshold light dose [4]. It is known that the amount of cell toxicity should exceed a minimum value to promote tissue necrosis.…”

Section: Introductionmentioning

confidence: 99%

“…This prevents PDT to take over its full potentiality. Many authors have investi-gated alternative ways to increase PDT efficiency developing new drugs [3,4], new light sources [5], or even using combined drugs or combined light sources available [6].…”

Section: Introductionmentioning

confidence: 99%

Analysis of the combined effect of lasers of different wavelengths for PDT outcome using 600, 630, and 660 nm

et al. 2011

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Abstract:We investigated the effects of photodynamic therapy (PDT) outcome when combining three laser systems that produce light in three different wavelengths (600, 630, and 660 nm). Cooperative as well as independent effects can be observed. We compared the results of the combined wavelengths of light with the effect of single laser for the excitation of the photosensitizer. In the current experiment, the used photosensitizer was Photogem R (1.5 mg/kg). Combining two wavelengths for PDT, their cumulative dose and different penetrability may change the overall effect of the fluence of light, which can be effective for increasing the depth of necrosis. This evaluation was performed by comparing the depth and specific aspect of necrosis obtained by using single and dual wavelengths for irradiation of healthy liver of male Wistar rats. We used 15 animals and divided them in five groups of three animals. First, Photogem R was administered; follow by measurement of the fluorescence spectrum of the liver before PDT to confirm the level of accumulation of photosensitizer in the tissue. After that, an area of 1 cm 2 of the liver was illuminated using different laser combinations. Qualitative analysis of the necrosis was carried out through histological and morphological study.

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Comparative study of photodegradation of three hematoporphyrin derivative: Photofrin®, Photogem®, and Photosan®

Cited by 34 publications

References 39 publications

meso-Aryl-substituted free-base porphyrins: formation, structure and photostability of diprotonated species

meso-Aryl-substituted free-base porphyrins: formation, structure and photostability of diprotonated species

Efficacy of Photogem® (Hematoporphyrin Derivative) as a Photoactivatable Larvicide against Aedes aegypti (Diptera: Culicidae) Larvae

Analysis of the combined effect of lasers of different wavelengths for PDT outcome using 600, 630, and 660 nm

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