Comparative Study of Orange and its Main Bioactive Constituents as Remedy for Non-alcoholic Fatty Liver in Rats

Al‐Okbi, Sahar Y.; Mohamed, Doha A.; Abd-Elhady, Eman E; Hussein, Ahmed; Al-Siedy, Enas S.K.

doi:10.3923/pjbs.2018.359.368

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…These nutrients and bioactive compounds may act as antioxidants, anti-inflammatories and improve glucose and lipid metabolism and blood pressure ( D’Elia et al, 2021 ). Animal studies have shown that orange juice reduces the risk of CVDs by improving lipid and glucose metabolism, fat storage, inflammation and hypertension ( Al-Okbi et al, 2018 ; Berger et al, 2020 ; Mas-Capdevila et al, 2020 ; Yang et al, 2022 ). However, human studies are not conclusive regarding the beneficial role of orange juice in reducing the risk of CVD ( Corrêa et al, 2019 ; Lima et al, 2019 ; Stevens et al, 2019 ; Fidélix et al, 2020 ; Mas-Capdevila et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Blood orange juice intake changes specific bacteria of gut microbiota associated with cardiometabolic biomarkers

et al. 2023

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Blood orange juice is an important source of flavanones and anthocyanins, mainly hesperidin, narirutin, and cyanidin-3-O-glucoside. The benefits of these bioactive compounds have been reported, but the mechanistic details behind their biological effects are not well established. This study investigated the effects of Moro orange (Citrus sinensis L. Osbeck) juice (MOJ) on gut microbiota composition and cardiometabolic biomarkers in overweight women. In this study, 12 overweight women (BMI from 25.0 to 29.9 kg/m2), aged 18–37 years, consumed 500 mL of MOJ every day for 4 weeks. We assessed the gut microbiota composition, levels of short-chain fatty acids (SCFAs), cardiometabolic biomarkers, and insulin resistance (HOMA-IR) at baseline and after 2 weeks and 4 weeks of MOJ intake. The results suggested that MOJ intake affected the abundance of specific operational taxonomic units (OTUs) of the gut microbiota but did not significantly alter the diversity and general composition of the gut microbiota. However, MOJ intake increased the production of SCFAs, especially propionic and isobutyric acids, and significantly improved cardiometabolic biomarkers such as blood pressure and plasma VCAM-1 levels in the overweight women. Additionally, we observed significant associations between gut microbiota OTUs belonging to the Bacteroidetes phyla and Prevotella 9 genera and the cardiometabolic biomarkers. Furthermore, MOJ reduced fasting glucose and insulin levels and HOMA-IR values, thereby enhancing insulin sensitivity in the insulin-resistant overweight women. Finally, we highlighted the importance of orange juice intake duration because some beneficial changes such as blood pressure improvements were evident at the 2-week time interval of the intervention, but other changes became significant only at the 4-week interval of MOJ intake. In conclusion, our study demonstrated that changes in specific OTUs of the gut microbiota in response to MOJ intake were associated with significant improvements in some cardiometabolic biomarkers and SCFA levels in overweight women with insulin resistance.

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Section: Introductionmentioning

confidence: 99%

Blood orange juice intake changes specific bacteria of gut microbiota associated with cardiometabolic biomarkers

et al. 2023

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Date Palm as Source of Nutraceuticals for Health Promotion: a Review

Al‐Okbi

2022

Curr Nutr Rep

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Purpose of Review Chronic diseases are problematic to health professional specially when using drugs throughout the course of life with un-tolerated side effects. Returning to nature through using nutraceuticals might have both protective and therapeutic effects. Date palm was claimed to be a good source of such nutraceuticals or functional food ingredients. The purpose of the present review was to spot light on the different phytochemicals, phytonutrients, and remedial effects of date palm (Phoenix dactylifera L.) in a goal to be utilized in form of nutraceuticals. The possible mechanisms of action of the remedial effects were among the aim of the study. Recent Findings A protein hydrolyzate prepared from date seed could prevent DNA mutation and susceptibility to cancer. In addition to cancer prevention, date palm fruit improved the treatment outcome of cancer pediatric patients and possesses anti-angiogenic activity as one of the important anticancer mechanisms of action. On the other hand, date seed extracts was recently reported to protect from ulcerative colitis. It seems that all the aforementioned remedial effect might be ascribed to immunoregulatory effect of date palm. These findings proposed that date palm is beneficial for health. Summary Date palm fruit is a rich source of vitamins, minerals, dietary fibers, energy, and easily digestible and absorbable sugars that instantaneously replenish and revitalize the body specially after fasting condition. Mineral contents in date fruits include potassium, phosphorus, magnesium, and calcium. Diverse health claims were reported to belong to various parts of the tree including the edible part of fruits, the seeds, the leaves, spathe (an envelope-like structure that encloses male and female date palm flowers), and pollen grains due to the presence of different bioactive constituents. The main phytochemicals and phytonutrients reported in date palms are phenolic compounds, carotenoids, sterols, anthocyanins, and others. In folk medicine, date palm fruits are used for enhancing immunity and treating gastrointestinal tract disorders, edema, bronchitis, wound, cancer, as well as infectious diseases. However, the exact health benefits and remedial effects of date palm were not fully and deeply investigated. The present review focused on the bioactive constituents and the reported health benefits of date palm and proposed mechanism of action.

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Mixtures of Tea andCitrus maxima(pomelo) Alleviate Lipid Deposition in HepG2 Cells Through the AMPK/ACC Signaling Pathway

Wen

et al. 2020

Journal of Medicinal Food

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Comparative Study of Orange and its Main Bioactive Constituents as Remedy for Non-alcoholic Fatty Liver in Rats

Cited by 3 publications

References 37 publications

Blood orange juice intake changes specific bacteria of gut microbiota associated with cardiometabolic biomarkers

Blood orange juice intake changes specific bacteria of gut microbiota associated with cardiometabolic biomarkers

Date Palm as Source of Nutraceuticals for Health Promotion: a Review

Mixtures of Tea andCitrus maxima(pomelo) Alleviate Lipid Deposition in HepG2 Cells Through the AMPK/ACC Signaling Pathway

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