Comparative study of lymphatics and bllod vessels.

Kubo, Hidemichi; Otsuki, Yoshinori; Magari, Sumiko; Sugimoto, Osamu

doi:10.1267/ahc.23.621

Cited by 3 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other techniques are toluidine blue staining following arterial perfusion–fixation and staining of basement membrane components, such as laminin and collagen type IV (Kubo et al. 1990).…”

Section: Markers Of Lymphatic Endothelial Cellsmentioning

confidence: 99%

Lymphatics at the crossroads of angiogenesis and lymphangiogenesis

Scavelli¹,

et al. 2004

View full text Add to dashboard Cite

The lymphatic system is implicated in interstitial fluid balance regulation, immune cell trafficking, oedema and cancer metastasis. However, the sequence of events that initiate and coordinate lymphatic vessel development (lymphangiogenesis) remains obscure. In effect, the understanding of physiological regulation of lymphatic vasculature has been overshadowed by the greater emphasis focused on angiogenesis, and delayed by a lack of specific markers, thereby limiting this field to no more than a descriptive characterization. Recently, new insights into lymphangiogenesis research have been due to the discovery of lymphatic-specific markers and growth factors of vascular endothelial growth factor (VEGF) family, such as VEGF-C and VEGF-D. Studies using transgenic mice overexpressing VEGF-C and VEGF-D have demonstrated a crucial role for these factors in tumour lymphangiogenesis.Knowledge of lymphatic development has now been redefined at the molecular level, providing an interesting target for innovative therapies. This review highlights the recent insights and advances into the field of lymphatic vascular research, outlining the most important aspects of the embryo development, structure, specific markers and methods applied for studying lymphangiogenesis. Finally, molecular mechanisms involved in the regulation of lymphangiogenesis are described.

show abstract

“…Other techniques are toluidine blue staining following arterial perfusion–fixation and staining of basement membrane components, such as laminin and collagen type IV (Kubo et al. 1990).…”

Section: Markers Of Lymphatic Endothelial Cellsmentioning

confidence: 99%