The Origins of Lymphatic Vessels

Ribatti, Doménico

doi:10.1016/b978-0-12-811313-4.00010-3

Cited by 2 publications

(2 citation statements)

References 113 publications

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“…A bunch of fundamental biological distinctions is present between the lymphatic and blood EC despite the topographical similarities, more than 400 differences in the expressed genes, returned to the difference in the functions of each ( Table 3 ) [ 78 ]. The lymphatic EC perform a semi-professional antigen-presenting to the lymphatic circulatory T cytotoxic CD8 cells through invadosome-like protrusion (MHC-I) and express specific surface antigens and receptors such as podoplanin, VEGFR-3, or lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) [ 79 , 80 ].…”

Section: Reviewmentioning

confidence: 99%

Tree of life: endothelial cell in norm and disease, the good guy is a partner in crime!

Marzoog

2023

Anat Cell Biol

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Undeniably, endothelial cells (EC) contribute to the maintenance of the homeostasis of the organism through modulating cellular physiology, including signaling pathways, through the release of highly active molecules as well as the response to a myriad of extrinsic and intrinsic signaling factors. Review the data from the current literature on the EC role in norm and disease. Endothelium maintains a precise balance between the released molecules, where EC dysfunction arises when the endothelium actions shift toward vasoconstriction, the proinflammatory, prothrombic properties after the alteration of nitric oxide (NO) production and oxidative stress. The functions of the EC are regulated by the negative/ positive feedback from the organism, through EC surface receptors, and the crosstalk between NO, adrenergic receptors, and oxidative stress. More than a hundred substances can interact with EC. The EC dysfunction is a hallmark in the emergence and progression of vascular-related pathologies. The paper concisely reviews recent advances in EC (patho) physiology. Grasping EC physiology is crucial to gauge their potential clinical utility and optimize the current therapies as well as to establish novel nanotherapeutic molecular targets include; endothelial receptors, cell adhesion molecules, integrins, signaling pathways, enzymes; peptidases.

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Section: Reviewmentioning

confidence: 99%

Tree of life: endothelial cell in norm and disease, the good guy is a partner in crime!

Marzoog

2023

Anat Cell Biol

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“…Several fundamental biological distinctions are present between lymphatic and blood EC despite the topographical similarities, more than 400 differences in the expressed genes, returning to the difference in the functions of each (Table 1) [39][40][41][42][43][44][45][46]. Lymphatic EC present semiprofessional antigen presentation to lymphatic circulatory T cytotoxic CD8 cells through an invadosome-shaped protrusion and express specific surface antigens and receptors such as podoplanin, vascular endothelial growth factor receptor-3 (VEGFR-3) or lymphatic vessel endothelial hyaluronan receptor-1 [47,48].…”

Section: Types Of Endothelial Cellsmentioning

confidence: 99%

Endothelial cell autophagy in the context of disease development

Marzoog

2022

Anat Cell Biol

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Endothelial cells (EC) are the anatomical boundaries between the intravascular and extravascular space. Damage to ECs is catastrophic and induces endothelial cell dysfunction. The pathogenesis is multifactorial and involves dysregulation in the signaling pathways, membrane lipids ratio disturbance, cell-cell adhesion disturbance, unfolded protein response, lysosomal and mitochondrial stress, autophagy dysregulation, and oxidative stress. Autophagy is a lysosomal-dependent turnover of intracellular components. Autophagy was recognized early in the pathogenesis of endothelial dysfunction. Autophagy is a remarkable patho (physiological) process in the cell homeostasis regulation including EC. Regulation of autophagy rate is disease-dependent and impaired with aging. Up-regulation of autophagy induces endothelial cell regeneration/differentiation and improves the function of impaired ones. The paper scrutinizes the molecular mechanisms and triggers of EC dysregulation and current perspectives for future therapeutic strategies by autophagy targeting.

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The Origins of Lymphatic Vessels

Cited by 2 publications

References 113 publications

Tree of life: endothelial cell in norm and disease, the good guy is a partner in crime!

Tree of life: endothelial cell in norm and disease, the good guy is a partner in crime!

Endothelial cell autophagy in the context of disease development

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