Comparative Study of Human and Rat Mammary Tumorigenesis

Russo, José; Gusterson, Barry A.; Rogers, Adrianne E.; Russo, Irma H.; Wellings, S. R.; Zwieten, Matthew J. van

doi:10.1007/978-1-4612-0485-5_15

Cited by 361 publications

(428 citation statements)

References 95 publications

(107 reference statements)

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“…Sections of tumours were stained with haematoxylin and eosin. Tumours were classified by applying criteria published elsewhere (Russo et al, 1990b. The proportions of DMBA-induced tumours and DMBAinduced adenocarcinomas were analysed by the chi-square test and Fisher's exact probability two-tail test (Zar, 1984).…”

Section: Methodsmentioning

confidence: 99%

Comparative study of the influence of pregnancy and hormonal treatment on mammary carcinogenesis

Russo

Koszalka²,

Russo³

1991

Br J Cancer

107

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Summary Since it has been shown that pregnancy protects the mammary gland from chemically induced carcinogenesis, this study was designed with the dual purpose of determining whether treatment of young virgin rats with the placental hormone chorionic gonadotropin (hCG) mimics pregnancy-induced changes in the tumourigenic response of the mammary gland and also whether the effect induced by both pregnancy and hormonal treatments was transitory, or a more permanent one, exerting the same effect when the period of time between delivery or termination of treatment and exposure to the carcinogen is lengthened. Virgin Sprague-Dawley rats were utilised in two experimental protocols. For protocol I, 50 day-old rats were either mated (Group II), or started receiving a daily intraperitoneal injection of 100 IU hCG (Group III) at age 50.Age-matched untreated virgin rats were used as controls (Group I). Twenty-one days after either delivery or termination of treatment all the animals received an intragastric dose of 8 mg DMBA/100 gbw. For the second protocol, 50 day-old virgin rats were also mated (Group V) or were treated with hCG for 21 days (Group VI); the resting period between delivery or termination of treatment was lengthened to 63 days, at which time they received a dose of DMBA. Age-matched controls (Group IV) received DMBA only. Tumourigenesis was evaluated 24 weeks post-carcinogen administration in all the groups. Pregnancy and hCG followed by the 21-day resting period significantly depressed mammary carcinogenesis to 11% and 6% respectively, compared with 63% in control animals. When the resting period was prolonged to 63 days there was also a significant depression in adenocarcinoma incidence to 9% in pregnancy (Group V) and 7% in hCG treated (Group VI) animals respectively, vs 18% in control animals (Group IV) in which it was observed that tumour incidence was also reduced as a consequence of aging at the time of exposure to the carcinogen. These results clearly indicate that hCG is as efficient as pregnancy and significantly reduces mammary carcinogenesis, and that the protective effect of both pregnancy and hCG treatment is long-lasting and both are more efficient than aging in reducing mammary carcinogenesis.

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Section: Methodsmentioning

confidence: 99%

Comparative study of the influence of pregnancy and hormonal treatment on mammary carcinogenesis

Russo

Koszalka²,

Russo³

1991

Br J Cancer

107

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“…Based on animal studies, it has been hypothesized that pregnancy induces differentiation and maturation of the breast cells and that the cells subsequently become less vulnerable to carcinogenic stimuli (Russo et al, 1990). Parous women and in particular multiparous women are known to be at a lower risk of breast cancer than nulliparous women.…”

mentioning

confidence: 99%

Parity, age at first childbirth and the prognosis of primary breast cancer

Kroman

Wohlfahrt²,

Andersen³

et al. 1998

Br J Cancer

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Summary Reproductive factors are known to be aetiologically important in breast cancer, but less is known regarding their effect on breast cancer prognosis. We have investigated the prognostic effect of age at first birth and total parity using data from the Danish Breast Cancer Cooperative Group that, since 1977, has collected population-based information on tumour characteristics, treatment regimes and follow-up status on Danish women with breast cancer. Details of pregnancy history were added from the Danish Civil Registration System and the National Birth Registry. Included in the study were 10 703 women with primary breast cancer. After adjusting for age and stage of disease (tumour size, axillary nodal status and histological grading), the number of full-term pregnancies was found without prognostic value. However, women with primary childbirth between 20 and 29 years experienced a significantly reduced risk of death compared with women with primary childbirth below the age of 20 years [20-24 years: relative risk (RR) = 0.88, 95% confidence interval (Cl) 0.78-0.99; 25-29 years: RR = 0.80, 95% Cl 0.70-0.91]. Further adjustment for oestrogen receptor status did not influence these results. The effect was not modified by age at diagnosis, tumour size or nodal status. In conclusion, low age at first childbirth, but not parity, was associated with a poor prognosis of breast cancer. We speculate whether women who develop breast cancer despite an early first full-term pregnancy might represent a selected group with a more malignant disease.

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“…In these experiments, breast carcinogenesis was initiated by chemicals which reacted with a highly proliferative and undifferentiated mammary epithelium [30].…”

Section: Differentiation Of Mammary Tissuementioning

confidence: 99%

Breast-feeding after breast cancer: if you wish, madam

Azim

Bellettini²,

Gelber

et al. 2008

Breast Cancer Res Treat

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Breast cancer is the most common malignant tumor-affecting women during the child bearing period. With the rising trend in delaying pregnancy later in life, the issue of subsequent pregnancy and lactation following breast cancer diagnosis has been more frequently encountered. In this context, data is scarce particularly those addressing the issue of lactation. In this review, we discussed different endocrinal, clinical and biological aspects dealing with breast-feeding after breast cancer in an attempt to determine how safe and feasible this approach is.

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Comparative Study of Human and Rat Mammary Tumorigenesis

Cited by 361 publications

References 95 publications

Comparative study of the influence of pregnancy and hormonal treatment on mammary carcinogenesis

Comparative study of the influence of pregnancy and hormonal treatment on mammary carcinogenesis

Parity, age at first childbirth and the prognosis of primary breast cancer

Breast-feeding after breast cancer: if you wish, madam

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