Comparative study of genotoxicity and tissue distribution of nano and micron sized iron oxide in rats after acute oral treatment

Singh, Shailendra Pratap; Rahman, M. F.; Murty, U. S. N.; Mahboob, M.; Grover, Paramjit

doi:10.1016/j.taap.2012.10.016

Cited by 98 publications

(73 citation statements)

References 46 publications

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“…In the work of (146-149) the genotoxicity of IONP is reported. Among these results the effect of IONP on human skin and lung cell lines were of considerable importance as drug carrier in humans (146). Iron may exist as ferrous (+2) or ferric (+3) form in NPs and both oxidation states show similar physicochemical properties.…”

Section: Iron Nanoparticlesmentioning

confidence: 99%

Nanotoxicity of Inert Materials: The Case of Gold, Silver and Iron

et al. 2016

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-Nanotechnology has opened a new horizon of research in various fields including applied physics, chemistry, electronics, optics, robotics, biotechnology and medicine. In the biomedical field, nanomaterials have shown remarkable potential as theranostic agents. Materials which are considered inert are often used in nanomedicine owning to their nontoxic profile. At nanoscale, these inert materials have shown unique properties that differ from bulk and dissolved counterparts. In the case of metals, this unique behavior not only imparts paramount advantages but also confers toxicity due to their unwanted interaction with different cellular processes. In the literature, the toxicity of nanoparticles made from inert materials has been investigated and many of these have revealed toxic potential under specific conditions. The surge to understand underlying mechanism of toxicity has increased and different means have been employed to overcome toxicity problems associated with these agents. In this review, we have focused nanoparticles of three inert metallic materials i.e. gold, silver and iron as these are regarded as biologically inert in the bulk and dissolved form. These materials have gained wider research interest and studies indicating the toxicity of these materials are also emerging. Oxidative stress, physical binding and interference with intracellular signaling are the major role player in nanotoxicity and their predominance is highly dependent upon size, surface coating and administered dose of nanoparticles. Current strategies to overcome toxicity have also been reviewed in the light of recent literature. The authors also suggested that uniform testing standards and well-designed studies are needed to evaluate nanotoxicity of these materials that are otherwise considered as inert.

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Section: Iron Nanoparticlesmentioning

confidence: 99%

Nanotoxicity of Inert Materials: The Case of Gold, Silver and Iron

et al. 2016

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“…The recommended dose according to the results of this study is 5 mg/kg, and we feel that this is the upper limit to balance the benefits and risks of sub-long term exposure to Fe 2 O 3 NPs (Ma et al, 2012). However, Singh et al (2013) showed that a 30 nm Fe 2 O 3 particle and bulk Fe 2 O 3 did not cause significant damage in % tail DNA, micronuclei formation, and chromosomal aberration at all tested doses and intervals. Similar in vivo genotoxicity studies with Fe 2 O 3 , using the comet assay, have not been reported.…”

Section: Discussionmentioning

confidence: 83%

Relationship between lymphocyte DNA fragmentation and dose of iron oxide (Fe2O3) and silicon oxide (SiO2) nanoparticles

et al. 2017

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ABSTRACT. At present, the use of nanoparticles is a controversial topic, especially when analyzing their effects in human tissues. Nanoparticles (NPs) can cause oxidative stress by increasing membrane lipids peroxidation and reactive oxygen species, and decreasing intracellular glutathione. Oxidative stress plays an important role in cell signaling ) and silicon oxide (SiO 2 ) NPs dissolved in saline solution were administered orally to the rats. Cardiac puncture was performed to extract peripheral blood for genotoxic analysis. DNA fragmentation for lymphocytes was performed. Control rats showed a fragmentation percentage of 11.20 ± 2.16%. Rats exposed to SiO 2 and Fe 2 O 3 NPs for 24 h showed statistically significant differences in DNA fragmentation percentages as compared with that of the control group. A lineal dose-response correlation between genotoxic damage and exposure to SiO 2 and Fe 2 O 3 NPs was found (r 2 = 0.99 and 0.98 for SiO 2 and Fe 2 O 3 , respectively). In conclusion, we found that exposure to Fe 2 O 3 and SiO 2 NPs can cause DNA fragmentation in lymphocytes in a dose-dependent manner.

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“…With growing consciousness, more studies have been performed on the safety and stability of such compounds as nanoparticulate zinc oxide (zincite), titanium dioxide (titania), cerium dioxide (ceria), and various iron oxides and oxide-hydroxides. [30][31][32][33][34][35][36][37] The growing knowledge and understanding of hazards emanating from nanoparticles is illustrated in the constant revision of the regulations over the last years. In the US, zinc oxide was approved by the FDA in 1999 for sun protection purposes.…”

Section: Nanoparticles As Uv Absorbers and Their Ecological And Toxicmentioning

confidence: 99%

Nanoparticulate inorganic UV absorbers: a review

2015

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Inorganic nanoparticles with UV-absorbing properties are an important class of UV filters. They can be used in various applications and in a variety of forms, including suspensions, nanocomposites, and solid thin films. In this review, an overview of the synthetic methods and their respective products is given for the most popular UV-absorbing nanomaterials, including zinc oxide, titanium dioxide, cerium dioxide and ferrous oxides, and oxyhydroxides.

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Comparative study of genotoxicity and tissue distribution of nano and micron sized iron oxide in rats after acute oral treatment

Cited by 98 publications

References 46 publications

Nanotoxicity of Inert Materials: The Case of Gold, Silver and Iron

Nanotoxicity of Inert Materials: The Case of Gold, Silver and Iron

Relationship between lymphocyte DNA fragmentation and dose of iron oxide (Fe<sub>2</sub>O<sub>3</sub>) and silicon oxide (SiO<sub>2</sub>) nanoparticles

Nanoparticulate inorganic UV absorbers: a review

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