Comparative study of genotoxic, antigenotoxic and cytotoxic activities of monoterpenes camphor, eucalyptol and thujone in bacteria and mammalian cells

Nikolić, Biljana; Vasilijević, Bojana; Mitić-Ćulafić, Dragana; Vuković-Gačić, Branka; Knežević-Vukčević, Jelena

doi:10.1016/j.cbi.2015.10.012

Cited by 56 publications

(41 citation statements)

References 45 publications

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“…A similar potency has been recently reported for camphor monoterpene, exerting a 50% reduction in viability at concentrations of 5.5 and 4.5 mM, respectively in HT-29 and HCT116 cells [67]. These published data suggest that both monoterpenes, when individually assayed, have only modest cytotoxic activity compared to other compounds in the rosemary extracts.…”

Section: Resultssupporting

confidence: 84%

Comparative Study of Green Sub- and Supercritical Processes to Obtain Carnosic Acid and Carnosol-Enriched Rosemary Extracts with in Vitro Anti-Proliferative Activity on Colon Cancer Cells

Sánchez‐Camargo

García‐Cañas

Herrero

et al. 2016

IJMS

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In the present work, four green processes have been compared to evaluate their potential to obtain rosemary extracts with in vitro anti-proliferative activity against two colon cancer cell lines (HT-29 and HCT116). The processes, carried out under optimal conditions, were: (1) pressurized liquid extraction (PLE, using an hydroalcoholic mixture as solvent) at lab-scale; (2) Single-step supercritical fluid extraction (SFE) at pilot scale; (3) Intensified two-step sequential SFE at pilot scale; (4) Integrated PLE plus supercritical antisolvent fractionation (SAF) at pilot scale. Although higher extraction yields were achieved by using PLE (38.46% dry weight), this extract provided the lowest anti-proliferative activity with no observed cytotoxic effects at the assayed concentrations. On the other hand, extracts obtained using the PLE + SAF process provided the most active rosemary extracts against both colon cancer cell lines, with LC50 ranging from 11.2 to 12.4 µg/mL and from 21.8 to 31.9 µg/mL for HCT116 and HT-29, respectively. In general, active rosemary extracts were characterized by containing carnosic acid (CA) and carnosol (CS) at concentrations above 263.7 and 33.9 mg/g extract, respectively. Some distinct compounds have been identified in the SAF extracts (rosmaridiphenol and safficinolide), suggesting their possible role as additional contributors to the observed strong anti-proliferative activity of CA and CS in SAF extracts.

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Section: Resultssupporting

confidence: 84%

Comparative Study of Green Sub- and Supercritical Processes to Obtain Carnosic Acid and Carnosol-Enriched Rosemary Extracts with in Vitro Anti-Proliferative Activity on Colon Cancer Cells

Sánchez‐Camargo

García‐Cañas

Herrero

et al. 2016

IJMS

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“…Besides, the synergistic cytotoxic effects among the Egyptian AFEO components may be more potent than among our oil components. Oxygenated monoterpenoids (7,12,13,14,16,17,18,19,20,21,22,24,25,26,27,28,29,30) 72.23 RT: Retention time, compounds were ordered according to their retention time; RI: Retention index, both from literature and experimentally determined. 32,33 Tyrosinase is the key enzyme in the biosynthesis of melanin and tyrosinase inhibitors can be used in cosmetics as whitening agents, in addition to their use as antibrowning in food industry.…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition and Biological Activity of the Essential Oil Isolated from the Leaves of Achillea fragrantissima Growing Wild in Yemen

Mansi¹,

Ali²,

Mhaidat³

et al. 2019

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Background: Yemen is diverse in its geography and rich in its natural flora. Achillea fragrantissima grown wild in Yemen is widely used in folkloric medicine. Objectives: To investigate the chemical composition, cytotoxicity, xanthine oxidase inhibitory and tyrosinase inhibitory activities of the essential oil isolated form the leaves of Achillea fragrantissima (Forssk.) Sch. Bip. growing wild in Yemen. Materials and Methods: The oil was collected after hydrodistillation for 3 h, the oil composition was analyzed by GC-MS and assayed for biological activities. Results: Artemisia ketone (49.53%), camphor (14.73%), α-bisabolol (11.20%), α-bisabolol oxide B (2.62%) were the main components of the oil. The MTT assay of the oil on two human colorectal cancer cell lines (SW480 and HCT-116) showed IC 50 values of 110.1 and 134.6 µg ml⁻¹, respectively. Xanthine oxidase inhibitory and tyrosinase inhibitory activity assays were performed but exhibited only marginal activities. Conclusion: the components of the essential oil could be excellent anticancer drugs for treatment of colon cancer

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“…This anticancer activity may be due to the active constituents present in the essential oil [13], such as Limonene that show cytotoxicity against breast carcinoma [23], and Mayurone that has anticancer against (MCF-7) cells [24], Borneol that exhibit cytotoxic activity against (HepG2, Caco-2 and VH10) cell lines [25], Bisabolene that demonstrate cytotoxic activity against breast cancer [26], Cymene that has cytotoxic activity against (HepG2, K562, and B16-F10) cell lines [27], Camphor that appear cytotoxic activity against MRC-5, HT-29 and HCT 116 cell lines [28].…”

Section: Resultsmentioning

confidence: 99%

The Evaluation of Antimicrobial and Cytotoxic Activity of the Essential Oil Extracted From the Aerial Parts of Southernwood Herb (Artemisia Abrotanum L.) That Recently Grown in Iraq

Almahdawy

Said

Abbas

et al. 2017

Asian J Pharm Clin Res

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Objective: This research is to study the assessment of the antimicrobial and cytotoxic activity of the essential oil extracted from the aerial parts of Artemisia abrotanum L. that recently grown in Iraq. Methods:The essential oil of A. abrotanum was extracted by hydrodistillation using Clevenger apparatus. This essential oil was tested for antimicrobial activity of five different pathogenic microorganisms (Gram-positive [Staphylococcus aureus and Bacillus subtilis] and Gram-negative [Salmonella typhi and Escherichia coli] bacterial strains) and fungi: Candida albicans using diffusion well agar method. Furthermore, this essential oil was tested for cytotoxic activity using rhabdomyosarcoma cell line, and the growth or inhibition of cancer cells was measured by MTT method. Results:The obtained results show that the antibacterial activity for A. abrotanum against S. aureus was at concentrations 40, 25, and15 µl with minimum inhibitory concentrations of 20 mm, while it showed antibacterial activity against E. coli for four different concentrations of 40, 25, 15, and10 μl with inhibition zone of 16, 12, 14, and 10 mm, respectively, and it showed antifungal activity against C. albicans at four concentrations 40, 25, 15, and10 μl with inhibition zone of 18, 24, 26, and 30 mm, respectively. The cytotoxic activity of the extracted essential oil was showed that the three concentrations of the extract (25, 50, and 100 μg/ml) were all lower significantly as compared to dimethyl sulfoxide group. A significant difference was seen for group 25 with both groups 50 and 100, but no significant difference was seen between the two later. Finally, the antimicrobial and anticancer activity of this plant could be due to its essential oil constituents: Borneol, cymene, camphor, terpineol, eucalyptol, and aromadendrene. Conclusion:The essential oil of A. abrotanum L. has a potent antimicrobial and anticancer effect against the tested microbial organisms and the cancer cells.

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Comparative study of genotoxic, antigenotoxic and cytotoxic activities of monoterpenes camphor, eucalyptol and thujone in bacteria and mammalian cells

Cited by 56 publications

References 45 publications

Comparative Study of Green Sub- and Supercritical Processes to Obtain Carnosic Acid and Carnosol-Enriched Rosemary Extracts with in Vitro Anti-Proliferative Activity on Colon Cancer Cells

Comparative Study of Green Sub- and Supercritical Processes to Obtain Carnosic Acid and Carnosol-Enriched Rosemary Extracts with in Vitro Anti-Proliferative Activity on Colon Cancer Cells

Chemical Composition and Biological Activity of the Essential Oil Isolated from the Leaves of Achillea fragrantissima Growing Wild in Yemen

The Evaluation of Antimicrobial and Cytotoxic Activity of the Essential Oil Extracted From the Aerial Parts of Southernwood Herb (Artemisia Abrotanum L.) That Recently Grown in Iraq

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