Comparative study of gamma glutamyl transferase, alkaline phosphatase and its αl isoenzyme as biological indicators of liver metastases

Clinical value of biliary alkaline phosphatase in non-jaundiced cholangiocarcinoma

“…An increased expression of liver ALP at the surface of hepatocyte plasma membranes, accompanied by the shedding of liver plasma membrane fragments is thought to be responsible for the presence of BALP in these patients (Van Hoof and De Broe 1994;Deng et al 1996). The clinical value of the BALP isoform in detecting liver metastasis has been evaluated by several investigators (Viot et al 1981;Viot et al 1983;Karmen et al 1984;Nishio et al 1986;Yeh et al 1989;Yorio et al 2000).…”

Serum Enzymes and Enzyme Profiles in the Diagnosis of Liver and Biliary Tract Disease

“…It has been claimed that the fast a! fraction on cellulose acetate electrophoresis can detect hepatic neoplasia with a sensitivity and specificity of 96 and 94%, respectively [27,28]. Unfortu nately, these studies have omitted cholestatic patients as controls.…”

“…High molecular weight (fast moving) AP isoenzyme correlates well with the presence of liver métastases, and appears in serum due, in part, to local biliary stasis [27,28,30,91,92], Several large scries involving patients with primary and secondary liver cancer [93][94][95][96] have shown that 5'-nucleotide phospho diesterase isoenzyme V has a sensitivity of 88% in the detection of hepatoma, and a sim ilar sensitivity in detecting patients with he patic métastasés. Abnormal values for a-fetoprotein were only found in 40% of the cases, and the enzyme test was especially valuable in the remaining 60%.…”

Evaluation of serum adenosine deaminase and 5′-nucleotidase activities as probable markers in ovarian cancer

“…Likewise, increased ADA activity in serum and tumour tissues has been reported in cancer conditions of various tissues like skin, breast and colon (1,2,3). Similarly serum 5'-NT level is reported to be elevated in cancers of the ovary (4) and liver (5,6).…”