Comparative study of effects of cadmium cations in free and chelated forms on activity of glutathione S-transferase, growth, and endocytosis in culture of the infusoriumTetrahymena pyriformis

Шемарова, И. В.; Maizel, E. B.; Khovanskikh, A. E.

doi:10.1007/bf02754322

Cited by 1 publication

(2 citation statements)

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“…Shemarova et al studied the effects of Cd 2? ions on activity of glutathione S-transferase, growth and endocytosis in culture of the infusorium Tetrahymena pyriformis (Shemarova et al 2000). Exposure of cells of the infusorium Tetrahymena pyriformis of the micronucleus-free strain GL to Cd 2?…”

Section: Cadmium and Endocytosis Processesmentioning

confidence: 99%

“…cations, respectively. This decrease was probably due to a high rate of accumulation of metal ions during this period (Shemarova et al 2000). Invertebrate species such as bivalve mollusks and worms were also used in immunotoxicological studies as they exist in direct contact with contaminated aquatic sediments and soil, respectively (Sauve et al 2002a, b).…”

Section: Cadmium and Endocytosis Processesmentioning

confidence: 99%

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Cadmium and transport of ions and substances across cell membranes and epithelia

2010

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Toxic metals such as cadmium (Cd(2+)) pose serious risks to human health. However, even though the importance of Cd(2+) as environmental health hazards is now widely appreciated, the specific mechanisms by which it produces its adverse effects have yet to be fully elucidated. Cd(2+) is known to enter cells, it binds and interacts with a multitude of molecules, it may indirectly induce oxidative stress and interfere with gene expression and repair of DNA. It also interacts with transport across cell membranes and epithelia and may therefore disturb the cell's homeostasis and function. Interaction with epithelial transport, especially in the kidney and the liver, may have serious consequences in general health. A lot of research still needs to be done to understand the exact way in which Cd(2+) interferes with these transport phenomena. It is not always clear whether Cd(2+) has primary or secondary effects on cell membrane transport. In the present review we try to summarize the work that has been done up to now and to critically discuss the relevance of the experimental work in vitro with respect to the in vivo situation.

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Section: Cadmium and Endocytosis Processesmentioning

confidence: 99%

Section: Cadmium and Endocytosis Processesmentioning

confidence: 99%