Comparative Study of Different Solvents Extract of Persea americana Leaf on Alloxan Induced Hyperglycemic Rats

Mashi, J.A.; Atiku, M. K.; Shehu, D.; Idris, R. I.; Said, Alshaimaa M.; Dangambo, M. A.; Babagana, K.; Ya’u, Mustapha

doi:10.3923/ajbs.2019.67.72

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…In the present study, phytochemical screening showed the presence of triterpenes, flavonoids, phenols, and tannins compounds within the extract of H. sabdariffa. Several studies have demonstrated the involvement of phytochemical compounds such as triterpenes [31,32], flavonoids [33][34][35], and tannins [36] for the management of diabetes. These compounds might act by several mechanisms such as enhancing insulin secretion [37] or regenerating insulinproducing pancreatic β-cell population in the islets of Langerhans [38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic potential of Hibiscus sabdariffa extract in alloxan-induced diabetic rats

Hamadjida¹,

Metechie²,

Tchiengang³

et al. 2023

GSC Biol. Pharm. Sci.

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Plants are known to possess relatively high efficacy in the treatment of several chronic diseases with fewer adverse effects. In the recent years, numerous medicinal plants have been reported to be effective in treating diabetes. Hence, the present study aims to evaluate the antidiabetic property of hydroalcoholic extract of Hibiscus sabdariffa (HS) calyces in diabetic rats. Diabetes was induced by single intraperitoneal injection of alloxan (150 mg/kg, b.w), in male Wistar rats. Diabetic rats were administered daily oral doses of HS (100, 200 and 400 mg/kg body weight) and Glibenclamide (10 mg/kg) for 21 days. Then, blood glucose levels, oral glucose tolerance test and lipid profiles were determined. Treatment with HS resulted in a significant dose dependent reduction of blood glucose levels accompanied by a significant improvement in body weight. The extract also enhanced the glucose tolerance and significantly decreased cholesterol, triglycerides, and low-density lipoproteins levels while the high-density lipoproteins level significantly increased. From the results obtained, it can therefore be concluded that Hibiscus sabdariffa has an antidiabetic effect in alloxan-induced diabetic rats.

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Section: Discussionmentioning

confidence: 99%

Antidiabetic potential of Hibiscus sabdariffa extract in alloxan-induced diabetic rats

Hamadjida¹,

Metechie²,

Tchiengang³

et al. 2023

GSC Biol. Pharm. Sci.

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“…The significant decreased blood glucose level in the treated groups of rats compared with the untreated rats could be due to the presence of one or more phytochemicals contained in the methanolic seeds extract of Hibiscus sabdariffa capable of either enhancing insulin secretion or regenerating insulin-producing pancreatic betaislets (Farzaei et al, 2015). Flavonoids and phenols have been reported to possess antioxidant activities which could be responsible for the antidiabetic properties of the extract via insulin modulation (Mashi et al, 2019). Saponins are effective in lowering blood glucose levels either by restoring insulin response, the induction of the release of insulin from the pancreas.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic and Hypolipidemic Effect of Methanol Extract of Hibiscus Sabdariffa Seed in Alloxan Induced Diabetic Albino Rats

Adefolalu¹,

Salawa²,

Gara³

et al. 2020

Nig J Bas App Sci

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This study investigated the hypoglycemic and hypolipidemic effect of the oral administration of methanol extract of Hibiscus sabdariffa seed in alloxan induced diabetic albino rats. Two different doses (200 and 400 mg/kg) of the methanol extract of Hibiscus sabdariffa seed were administered daily to two groups of diabetic rats for a period of two weeks. Metformin (250 mg/kg) was given as the reference standard drug. Phytochemical, acute toxicity, fasting blood glucose, body weight, cholesterol, triglycerides and lipoproteins levels were determined using standard methods. Acute toxicity of methanol extract of Hibiscus sabdariffa seed was estimated to be greater than 5000 mg/kg body weight. There was an initial decrease in the body weight of the experimental animals after induction of diabetes which increased significantly (p<0.05) by the second week of treatment. The fasting blood glucose levels of the treated diabetic rats were significantly decreased at the second week of treatment with the group that received 400 mg/kg of extract recording the lowest fasting blood glucose level. The cholesterol, triglycerides and low density lipoproteins levels of the diabetic treated rats were significantly reduced while the high density lipoproteins level significantly increased. It can therefore be concluded that Hibiscus sabdariffa seed has the ability to lower blood sugar and maintain a stable lipid level. Keywords: Hypoglycemic, hypolipidemic, Alloxan, Phytochemical, Hibiscus sabdariffa

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“…Evaluation of hypoglycemic and hypolipidemic activities of ethyl acetate fraction of P.americana leaf were carried out in alloxan-induced diabetic rats. The extract was observed to demonstrate significant antidiabetic [28] and hypolipidemic activities in alloxan-induced diabetic rats. The observed hypoglycemic activity might be associated with the presence of some trace element in the extract such as Zn, Cr, Mg, Mn etc.…”

Section: Discussionmentioning

confidence: 96%

“…Diabetes mellitus causes a drastic change in body weight [27,28], which may be due to excessive breakdown of tissue proteins and lipids caused by insulin insufficiency. Evaluation of hypoglycemic and hypolipidemic activities of ethyl acetate fraction of P.americana leaf were carried out in alloxan-induced diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycaemic and Hypolipidemic Properties of Ethyl Acetate Fraction of <i>P. americana</i> Leaf in Alloxan-Induced Diabetic Rats

Mashi¹

2018

IJBBMB

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Diabetes is a heterogeneous disorder with multiple etiologies resulting in major healthcare problem such as risk of heart disease, stroke and micro-vascular complications such as blindness, renal failure and peripheral neuropathy. The research was aimed at evaluating the antihyperglycaemic and antihyperlipidemic potentials of ethyl acetate fraction of Persea americana leaf in alloxan-induced diabetic rats. Persea americana leaf was extracted by soxhlet extraction for 24hrs and concentrated in vacuo to yield Persea americana extract (PAE). Elemental compositional analysis of the extract was determine using flame atomic absorption spectroscopy. Hyperglycemia was induced by intraperitoneal administration of alloxan. Blood glucose levels determined using ACCUCHEK. Hypoglycemic activity was evaluated by measuring serum glucose level and insulin level. Hypolipidemic activity was evaluated by measuring various biochemical parameters like total cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein and high density lipoprotein. Elemental compositional analysis of the Fraction reveals the presence of Zn, Cr, Mg, Fe, Cu and Mn. The levels of fasting blood glucose were found to decrease significantly in the treated groups in a dose dependent pattern with reversal in body weight lost as well as significant increase in serum insulin level compared with the diabetic control group. The results showed that serum total cholesterol, triglyceride, low density lipoprotein and very low density lipoprotein levels were statistically lower in the treated groups. The observed hypoglycaemic alongside with hypolipidemic effect can be associated with the levels of trace elements present in the extract. The present study support the traditional claim in the use of ethyl acetate extract of P. americana leaf as hypoglycaemic and hypolipidemic agent.

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Comparative Study of Different Solvents Extract of Persea americana Leaf on Alloxan Induced Hyperglycemic Rats

Cited by 7 publications

References 21 publications

Antidiabetic potential of Hibiscus sabdariffa extract in alloxan-induced diabetic rats

Antidiabetic potential of Hibiscus sabdariffa extract in alloxan-induced diabetic rats

Hypoglycemic and Hypolipidemic Effect of Methanol Extract of Hibiscus Sabdariffa Seed in Alloxan Induced Diabetic Albino Rats

Hypoglycaemic and Hypolipidemic Properties of Ethyl Acetate Fraction of <i>P. americana</i> Leaf in Alloxan-Induced Diabetic Rats

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Comparative Study of Different Solvents Extract of Persea americana Leaf on Alloxan Induced Hyperglycemic Rats

Cited by 7 publications

References 21 publications

Antidiabetic potential of Hibiscus sabdariffa extract in alloxan-induced diabetic rats

Antidiabetic potential of Hibiscus sabdariffa extract in alloxan-induced diabetic rats

Hypoglycemic and Hypolipidemic Effect of Methanol Extract of Hibiscus Sabdariffa Seed in Alloxan Induced Diabetic Albino Rats

Hypoglycaemic and Hypolipidemic Properties of Ethyl Acetate Fraction of &lt;i&gt;P. americana&lt;/i&gt; Leaf in Alloxan-Induced Diabetic Rats

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Hypoglycaemic and Hypolipidemic Properties of Ethyl Acetate Fraction of <i>P. americana</i> Leaf in Alloxan-Induced Diabetic Rats