Comparative study of cutaneous leishmaniasis in human immunodeficiency virus (HIV)-infected patients and non-HIV-infected patients in French Guiana

Couppié, Pierre; Clyti, E.; Sobesky, M.; Bissuel, F.; Giudice, P. Del; Sainte‐Marie, D.; Dédet, J. P.; Carme, Bernard; Pradinaud, R.

doi:10.1111/j.1365-2133.2004.06226.x

Cited by 71 publications

(57 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Of note is the rapid evolution within 3 months from LCL in both feet to a disseminated pathology, with multiple ulcerative lesions in the face and upper and lower limbs, a pathology already observed in other co-infection cases reported in Latin America. [10][11][12][13][14][15][16][17] Additionally, the patient presented with ML, characterized by several lesions on the lips, palate, pharynx, larynx, and bronchia, which probably caused the severe dysphonia, dysphagia, and hyper-secretion. The patient reported to have gone to work in an area (i.e., Chapare) known to be endemic for LCL and ML.…”

Section: Discussionmentioning

confidence: 99%

“…8 In contrast to VL, only scarce data are available on LCL in HIV-infected patients in the Americas, with isolated case reports available from Argentina, Brazil, Colombia, French Guyana, Peru, and Venezuela. 8 Literature on ML in HIV-infected patients is even rarer, with only a dozen or so of cases reported in Argentina, 9 Brazil, [10][11][12][13][14] French Guyana, 15,16 and Peru. 17 We describe an ML patient attending the Hospital of Viedma Hospital in Cochabamba, Bolivia, who on further examination, was found to be infected with HIV; the patient was started on amphotericin B therapy, responded well, but was lost to follow-up.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Co-Infection of Leishmania (Viannia) braziliensis and HIV: Report of a Case of Mucosal Leishmaniasis in Cochabamba, Bolivia

Torrico

Parrado²,

Castro³

et al. 2009

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Co-Infection of Leishmania (Viannia) braziliensis and HIV: Report of a Case of Mucosal Leishmaniasis in Cochabamba, Bolivia

Torrico

Parrado²,

Castro³

et al. 2009

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…Moreover, recurrence of cutaneous Leishmaniasis has been observed in HIV-1-infected patients with only moderate immunosuppression (COUPPIE et al, 2004). Skin lesions have been reported in HIV-infected patients since the first descriptions of the disease (CARDOSO et al, 2002).…”

Section: Introductionmentioning

confidence: 96%

Evaluation of HIV-Leishmania co-infection in patients from the northwestern Paraná State, Brazil

Oliveira

Celidônio

Silveira

et al. 2011

Acta Sci. Health Sci.

View full text Add to dashboard Cite

ABSTRACT. Leishmaniasis occurs throughout the world and is one of the opportunistic infections that attack HIV-infected individuals. Few data are available on American cutaneous leishmaniasis (ACL) in HIV-infected patients. Current research investigates the occurrence of HIV-Leishmania co-infection in HIV-infected individuals in an endemic region in Southern of Brazil. A non-randomized transversal investigation, molecular and serum epidemiologic type, on the occurrence of ACL in 169 HIV-infected patients was undertaken. The patients were followed up at the Integrated Nucleus of Health of the city Maringá, Southern of Brazil. Results showed that 13 (7.7%) of the HIV-infected patients also presented Leishmania (Viannia) DNA, detectable in blood by PCR. Serology, direct research, culture and PCR in skin material produced negative results. PCR positiveness for Leishmania was not associated with CD4 T lymphocytes count, opportunistic disease, treatment, use of proteases inhibitors, tattooing/piercing or use of injectable drugs, residential environment or previous ACL history. Results show that HIVinfected patients who live in endemic areas may reveal Leishmania DNA in the blood without any ACL symptoms. Above findings may be attributed to anti-retrovirus medicine that controls viral replication and maintains the functionality of the immune system and to a possible antiLeishmania activity of these drugs.Keywords: american cutaneous leishmaniasis, HIV, co-infection, polymerase chain reaction.RESUMO. Avaliação da co-infecção HIV-Leishmania em pacientes da região noroeste do Estado do Paraná, Brasil. As leishmanioses ocorrem em todo o mundo e são infecções oportunistas que afetam indivíduos portadores do vírus HIV. Este estudo investigou a ocorrência da co-infecção HIV-Leishmania em portadores do HIV numa região endêmica para LTA do Sul do Brasil. Foi realizado estudo transversal, não randomizado, utilizando metodologia molecular e sorológica, sobre a ocorrência de LTA em 169 portadores do HIV. Foram estudados pacientes atendidos no Núcleo Integrado de Saúde de Maringá, Paraná, Sul do Brasil. Observou-se que 13 (7,7%) dos pacientes infectados pelo HIV também apresentavam o DNA de Leishmania (Viannia), detectável no sangue por PCR. A sorologia, pesquisa direta de Leishmania, cultura e PCR de lesões de pele foram negativas. A positividade da PCR não estava associada à contagem de linfócitos T CD4 + , doença oportunista, tratamento, uso de inibidores de protease, tatuagem, uso de drogas injetáveis, ambiente da residência ou história prévia de LTA. Os resultados mostraram que indivíduos portadores do vírus HIV que residem em área endêmica podem apresentar o DNA de Leishmania sem manifestar sintomas de LTA. Estes resultados podem ser atribuídos a ação dos medicamentos anti retrovirais que controlam a replicação viral mantendo a integridade do sistema imunológico ou a uma possível atividade anti-Leishmania destas drogas.Palavras-chave: leishmaniose tegumentar americana, HIV, co-infecção, reação em cadeia da polimerase.

show abstract

“…2 In South America, coinfection cases of ATL were reported in Argentina, Brazil, Colombia, French Guyana, Peru, and Venezuela, and were caused by Leishmania guyanensis and Leishmania braziliensis. [2][3][4][5] Immunosuppression is one of the strongest risk factors for overt clinical disease, and can also alter the disease presentation and treatment response. 1 All antileishmanial drugs are less effective in HIV-positive patients.…”

Section: Introductionmentioning

confidence: 99%

Coinfection of Leishmania guyanensis and Human Immunodeficiency Virus–Acquired Immune Deficiency Syndrome: Report of a Case of Disseminated Cutaneous Leishmaniasis in Ecuador

Calvopiña

Aguirre²,

Cevallos

et al. 2017

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. Reported herein is the first case of Leishmania-human immunodeficiency virus (HIV) coinfection in Ecuador. In Ecuador, HIV infections overlap endemic areas of leishmaniasis. Immunosuppression is a wellestablished risk factor for developing severe disease. This is a severe case of a 32-year-old man presenting with disseminated pleomorphic ulcers, papules, and cutaneous plaque-like lesions over his whole body. Numerous amastigotes were observed in both skin scrapings and biopsies. The sequence of the cytochrome b gene confirmed the presence of Leishmania guyanensis. The patient was treated but failed to respond to meglumine antimoniate and amphotericin B. Six months later, the patient died due to bacterial septic shock.

show abstract

Comparative study of cutaneous leishmaniasis in human immunodeficiency virus (HIV)-infected patients and non-HIV-infected patients in French Guiana

Abstract: In French Guiana, cutaneous leishmaniasis in moderately immunosuppressed HIV-infected subjects (> 200 CD4+ T cells mm(-3)) is characterized by a higher rate of recurrence or reinfection and is more difficult to treat than that in HIV- subjects.

Cited by 71 publications

References 34 publications

Co-Infection of Leishmania (Viannia) braziliensis and HIV: Report of a Case of Mucosal Leishmaniasis in Cochabamba, Bolivia

Co-Infection of Leishmania (Viannia) braziliensis and HIV: Report of a Case of Mucosal Leishmaniasis in Cochabamba, Bolivia

Evaluation of HIV-Leishmania co-infection in patients from the northwestern Paraná State, Brazil

Coinfection of Leishmania guyanensis and Human Immunodeficiency Virus–Acquired Immune Deficiency Syndrome: Report of a Case of Disseminated Cutaneous Leishmaniasis in Ecuador

Contact Info

Product

Resources

About