Comparative Study of Cerebral Blood Flow in Patients With Normal-tension Glaucoma and Control Subjects

Sugiyama, Tetsuya; Utsunomiya, Keita; Ota, Hitoya; Ogura, Yasuharu; Narabayashi, Isamu; Ikeda, Tsunehiko

doi:10.1016/j.ajo.2005.08.037

Cited by 50 publications

(23 citation statements)

References 6 publications

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“…Some patients develop an AD-like perfusion pattern, but without clinical signs of AD. In those patients, the visual field defect progressed more rapidly than in NTG patients without an AD-like perfusion pattern [25]. In patients with CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy), the retinal capillary flow may be mildly to moderately reduced [26].…”

Section: Discussionmentioning

confidence: 99%

Detailed Illustration of the Visual Field Representation along the Visual Pathway to the Primary Visual Cortex: A Graphical Summary

Wärntges

Michelson²

2013

Ophthalmic Res

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Purpose: In the literature, different graphic illustrations are available, which depict different parts of the visual pathway in relation to visual field sectors, to retinal sectors, the layers of the lateral geniculate nucleus (LGN), or sections of the primary visual cortex (V1). However, a complete overview is missing, which may be useful for a more precise differentiation of predominantly ophthalmological from intracerebral diseases. It may also be of interest to investigate additional intracerebral reasons that are involved in impaired vision of largely unknown pathophysiology. Methods: This work combines the scientific knowledge of partial graphics in one detailed illustration that allows exact follow-up of the neuronal connections from individual visual field sectors to the V1 areas. A selective search for peer-reviewed graphics of the visual pathway was performed in PubMed and Google Pictures. Results: Sixteen different visual field sectors and their 16 corresponding retinal sectors were set in relation to 64 LGN sections and 20 areas of V1. Segmented cross-sectional areas of the optic nerve supplemented the graphical representation of the fiber orientation in relation to the visual field. Conclusion: The detailed illustration of the visual field projection along the visual pathway structures may facilitate a more precise calculation of correlations between morphological and functional measurements of ophthalmological and neuroradiological examinations.

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Section: Discussionmentioning

confidence: 99%

Detailed Illustration of the Visual Field Representation along the Visual Pathway to the Primary Visual Cortex: A Graphical Summary

Wärntges

Michelson²

2013

Ophthalmic Res

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“…The patient’s visual fields progressed without changes to IOP. Seven out of 31 normal tension glaucoma patients demonstrated cerebral blood flow patterns similar to Alzheimer’s Disease even though none were diagnosed with Alzheimer’s disease (Sugiyama, Utsunomiya, Ota, Ogura, Narabayashi & Ikeda, 2006). Visual field defects progressed more rapidly and cerebral blood flow was lower in these patients.…”

Section: Discussionmentioning

confidence: 99%

Arterial spin labeling fMRI measurements of decreased blood flow in primary visual cortex correlates with decreased visual function in human glaucoma

Duncan¹,

Sample²,

Bowd³

et al. 2012

Vision Research

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Purpose Altered metabolic activity has been identified as a potential contributing factor to the neurodegeneration associated with primary open angle glaucoma (POAG). Consequently, we sought to determine whether there is a relationship between the loss of visual function in human glaucoma and resting blood perfusion within primary visual cortex (V1). Methods Arterial spin labeling (ASL) functional magnetic resonance imaging (fMRI) was conducted in ten participants with POAG. Resting cerebral blood flow (CBF) was measured from dorsal and ventral V1. Behavioral measurements of visual function were obtained using standard automated perimetry (SAP), short-wavelength automated perimetry (SWAP), and frequency-doubling technology perimetry (FDT). Measurements of CBF were compared to differences in visual function for the superior and inferior hemifield. Results Differences in CBF between ventral and dorsal V1 were correlated with differences in visual function for the superior versus inferior visual field. A statistical bootstrapping analysis indicated that the observed correlations between fMRI responses and measurements of visual function for SAP (r = 0.49), SWAP (r = 0.63), and FDT (r = 0.43) were statistically significant (all p < 0.05). Conclusions Resting blood perfusion in human V1 is correlated with the loss of visual function in POAG. Altered CBF may be a contributing factor to glaucomatous optic neuropathy, or it may be an indication of post-retinal glaucomatous neurodegeneration caused by damage to the retinal ganglion cells.

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“…Increased variability in BP is widely recognized in cardiovascular and hypertension research as a signal of increased risk for end-organ damage 56 and, during recent years, its occurrence has been increasingly considered with regard to other vascular diseases, including glaucoma. [57][58][59] The mechanism by which such increased variability, during the nocturnal period in particular, may relate to the development of GON is unclear. It could be hypothesized that, because of the close relationship between BP and OPP, an increased variability in BP may subsequently lead to increased variability or fluctuation in OPP, which may have a particular effect nocturnally when OPP is already physiologically reduced and the optic nerve head is more vulnerable.…”

Section: Commentmentioning

confidence: 99%

Primary Open-Angle Glaucoma vs Normal-Tension Glaucoma

et al. 2013

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Comparative Study of Cerebral Blood Flow in Patients With Normal-tension Glaucoma and Control Subjects

Cited by 50 publications

References 6 publications

Detailed Illustration of the Visual Field Representation along the Visual Pathway to the Primary Visual Cortex: A Graphical Summary

Detailed Illustration of the Visual Field Representation along the Visual Pathway to the Primary Visual Cortex: A Graphical Summary

Arterial spin labeling fMRI measurements of decreased blood flow in primary visual cortex correlates with decreased visual function in human glaucoma

Primary Open-Angle Glaucoma vs Normal-Tension Glaucoma

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