Comparative Study of Biotin and Hydroxyapatite on Biological Properties of Composite Coating

Abstract

The ultimate goal of using biomaterials is to improve human health by restoring the function of natural living tissues and organs in the body. The present work aims to modify the composite coating layer properties by using two different types of bioactive reinforcing materials (biotin and hydroxyapatite) particles in different percentages (5% and 10%). Coatings were applied onto commercially pure Ti, SS 316 L, and SS 304 substrates by the dip-coating method. Characterization of samples includes microstructure observation by field emission scanning electron microscopy (FE-SEM), contact angle measurement (wettability), and MTT. The results show the addition of metallic particles (bioparticles) (hydroxyapatite particles, biotin) at 5 Vol. % improved the whole properties of composite materials. Using different particles’ scale size aids to enhance the combinations in the alginate matrix producing a dual effect on composite film properties. In addition, the inclusion of metallic particles has to increase the wettability by reducing the contact angle. At the same time, MTT graphs revealed that after 3 days of exposure in MG-63 cells, 316 L SS alloys’ surface following pack adhesion became more active.

Investigation of Roughness, Morphology, and Wettability Characteristics of Biopolymer Composite Coating on SS 316L for Biomedical Applications

“…The nanosilver precipitated at the surface of biotin within the chitosan matrix because of the large differences in particle size and surface charge of these particles, which decreased the roughness [ 50 , 51 ]. The incorporation of metallic particles enhanced the overall characteristics, while varying the particle scale size helps to optimize the combinations and reduce surface roughness [ 50 ]. Chitosan is precipitated with polyanions and in alkaline solutions [ 51 , 52 ].…”

“…The surface that has the smallest contact angle was for CS + nanosilver + biotin composite coating. The contact angle of this composite coating was found to be roughly 53.58 degrees because the agglomerate surface minimized the contact angle of the whole composite coating material, suggesting its hydrophilicity [ 50 ]. In comparison, other composite coatings such as those made from chitosan and silver nanoparticles have higher contact angles, indicating their hydrophobic nature [ 53 ].…”

Cold sintering process of hydroxyapatite derived from natural bone and co-precipitation method: a comparative study

“…The sintered samples have a grain size more significant than the grain size of the started powder, indicating the good densifications of HA samples. The growth of the grain to this level belongs to the high activity of the nanoparticles due to the increased surface area and the relatively slow heating rate during the sintering process [34][35][36][37][38][39][40][41][42][43]. While the sample sintered at 200°C and 100 MPa have the lower densification.…”

Mechanical and Numerical Analysis of Polymer-Natural Fiber Composites for Denture Applications

“…A manufacturing device called a denture is used for replacing the missing teeth [1]. In the medical and dental professions, there are numerous biomaterials available [2]. Polymeric-based material is often used in the manufacture of dentures [3].…”