Comparative study of apolipoprotein-E polymorphism and plasma lipid levels in dyslipidemic and asymptomatic subjects, and their implication in cardio/cerebro-vascular disorders

Ferreira, Cláudia N.; Carvalho, Maria G.; Fernandes, Ana Paula; Lima, Luciana Moreira; Loures-Valle, Andréia A.; Dantas, Julizar; Janka, Zoltán; Palotás, András; Sousa, Marinez O.

doi:10.1016/j.neuint.2009.09.016

Cited by 29 publications

(32 citation statements)

References 47 publications

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“…In this study, 34 and 32 allele frequencies were 7.9% and 6.1%, respectively. 21 Of the various apoE genotypes, the 33 33 was the most frequent genotype. Similar results were reported in other studies.…”

Section: Discussionmentioning

confidence: 97%

“…Similar results were reported in other studies. 6,7,10,21,22 Previously, studies in the pediatric population have shown that the apoE phenotype strongly influences the lipid profile in childhood. 23,24 A number of studies have investigated the contributory role of apoE polymorphism on plasma lipid levels [5][6][7]20,21 as well as its impact on CAD.…”

Section: Discussionmentioning

confidence: 99%

“…6,7,10,21,22 Previously, studies in the pediatric population have shown that the apoE phenotype strongly influences the lipid profile in childhood. 23,24 A number of studies have investigated the contributory role of apoE polymorphism on plasma lipid levels [5][6][7]20,21 as well as its impact on CAD. 7,10,19,20,21 The various apoE isoforms interact differently with specific lipoprotein receptors, ultimately altering circulating levels of cholesterol.…”

Section: Discussionmentioning

confidence: 99%

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The association of apolipoprotein E polymorphism and lipid levels in children with a family history of premature coronary artery disease

Çiftdoğan

Coşkun

Ulman

et al. 2012

Journal of Clinical Lipidology

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The association of apolipoprotein E polymorphism and lipid levels in children with a family history of premature coronary artery disease

Çiftdoğan

Coşkun

Ulman

et al. 2012

Journal of Clinical Lipidology

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“…Carriership of the other two common alleles of APOE may be associated with impaired clearance of lipoprotein particles, resulting in increased levels of plasma cholesterol and/or triglycerides. Carriership of APOE4 allele is associated with increased total and LDL cholesterol and triglycerides in plasma (a 'hyper-lipemic' lipid profile, hyperlipoproteinemia type III), and confers increased risk for vascular disease [52][53][54]. Carriership of a single E2 allele of APOE may be associated with lower cholesterol levels than E3 but, at the same time, higher triglyceride levels than E3 [55].…”

Section: Apoe -A Simple Lipoprotein Transporter a Major Amyloid Peptmentioning

confidence: 99%

APOE4, oxidative stress and decreased repair capacity - a no-brainer. Faulty lipid metabolism and increased levels of oxidative damage may be risk factors in the pathogenesis of late-onset dementia

Nayyar

Chakalova²

2015

Biodiscovery

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Keywords: Late-onset disease, dementia, APOE, mitochondrial DNA, individual repair capacity.Abbreviations: AD -Alzheimer's disease, APOE -apolipoprotein E, ATP -adenosine triphosphate, BER -base excision repair, CAA -cerebral amyloid angiopathy, CNS -central nervous system, FTD -frontotemporal dementia, HD -Huntington's disease, IMT -intimamedia thickness, IRC -individual repair capacity, MCI -mild cognitive impairment, MND -motor neuron disease, NER -nucleotide excision repair, NMDA -N-methyl-D-aspartate, PD -Parkinson's disease, PDAPP -PDGF promoter expressing amyloid precursor protein, ROS -reactive oxygen species; SOD -superoxide dismutase, VCI -vascular cognitive decline.* Corresponding Authors: Ashima Nayyar, email: a.nayyar@abertay.ac.uk Conflict of Interests:No potential conflict of interest was disclosed by any of the authors. AbstractDementia is very common in the elderly and its incidence increases in an age-dependent fashion. Alzheimer's disease and vascular cognitive decline are the most common cases of dementia in the elderly. Amyloid burden and increased levels of oxidative damage have been implicated to play significant roles in the pathogenesis of late-onset dementia. In this paper we propose that there are three major genetic factors that may modulate the risk for dementia in later life: carriership of APOE variant alleles, carriership of mitochondrial DNA of haplogroups associated with ineffective oxygen utilisation (specifically, haplogroup H) and carriership of genetic polymorphisms conferring subtly deficient DNA repair. All three factors are quite common in the European populations. Each of these three factors may not have significant effect on the phenotype when taken separately, but when combined in the same genotype, the effects may be cumulative. Further studies are needed in order to elucidate the genotype-phenotype relationships and provide a reliable basis for assessment of the genetic risk for sporadic late-onset dementia. Lifestyle alterations and therapies targeted at decreasing the oxidative burden to aging cells and tissues may decrease the risk for neurological decline in later life.

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“…ApoE may modulate the lipoprotein metabolism at different stages and influence total and low density lipoprotein cholesterol levels, as well as other lipid features [2].…”

Section: Introductionmentioning

confidence: 99%

Association of ApoE genetic polymorphisms with proximal deep venous thrombosis

Nagato

Pinhel

Godoy

et al. 2011

J Thromb Thrombolysis

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The aim of the current study was to evaluate a possible association between apolipoprotein E (ApoE) genetic polymorphisms and deep venous thrombosis. A case-control study of ApoE genetic polymorphisms was carried out in 60 male and female patients with deep venous thrombosis and 60 male and female controls. The ages of the patients ranged between 23 and 90 years old (mean ± standard deviation: 58 ± 16.56 years) and the ages of the control group, varied between 21 and 56 years old (mean ± SD: 33 ± 10.93 years). Genetic polymorphisms were analyzed in respect to the prevalence of alleles (APOE*2, APOE*3 and APOE*4) and genotypes (APOE*2/2, APOE*2/3, APOE*2/4, APOE*3/3, APOE*3/4 and APOE*4/4). The ε2 allele was more common in patients who had suffered thrombotic events (P = 0.0034). Additionally, there was a significant difference on comparing the distribution of alleles in female patients and female controls (P = 0.027). These results demonstrate an association between the ApoE ε2 allele and deep venous thrombotic events in women. This association opens the possibility of a new line of research to better understand these thrombotic events.

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Comparative study of apolipoprotein-E polymorphism and plasma lipid levels in dyslipidemic and asymptomatic subjects, and their implication in cardio/cerebro-vascular disorders

Cited by 29 publications

References 47 publications

The association of apolipoprotein E polymorphism and lipid levels in children with a family history of premature coronary artery disease

The association of apolipoprotein E polymorphism and lipid levels in children with a family history of premature coronary artery disease

APOE4, oxidative stress and decreased repair capacity - a no-brainer. Faulty lipid metabolism and increased levels of oxidative damage may be risk factors in the pathogenesis of late-onset dementia

Association of ApoE genetic polymorphisms with proximal deep venous thrombosis

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