Comparative study of antioxidant and anti-inflammatory activities and genotoxicity of alcoholic and aqueous extracts of four Fabiana species that grow in mountainous area of Argentina

Cuello, Soledad; Arena, Mario Eduardo; Zampini, Iris Catiana; Ordóñez, Roxana Mabel; Isla, Marı́a Inés

doi:10.1016/j.jep.2011.06.005

Cited by 17 publications

(12 citation statements)

References 31 publications

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“…ROS also play an important role in the pathogenesis of inflammation under oxidative stress (Cuello et al . ). Inflammation is a complex biological response to pathogens and damaged cells in the human body (Li and Wang ).…”

Section: Introductionmentioning

confidence: 97%

“…A number of plants have simultaneous antioxidant and anti‐inflammatory activities, including such species as Malva sylvestris , Borago officinalis , Capparis sicula and Raphanus raphanistrum (Cuello et al . ). Asparagus cochinchinensis (AC) is a plant from the Asparagaceae family found near seashores, thinly forested slopes, roadsides and waste fields in Korea.…”

Section: Introductionmentioning

confidence: 97%

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Phenolic Contents, Antioxidant and Anti-inflammatory Activities of Asparagus cochinchinensis (Loureiro) Merrill

Samad

Debnath

Hasnat

et al. 2013

Journal of Food Biochemistry

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Asparagus cochinchinensis (Loureiro) Merrill. (AC) is used as a traditional medicine for treating inflammation and oxidative stress-related diseases. In this study, aqueous extract of AC tuber was investigated to determine the antioxidant and anti-inflammatory activities. Free radical-scavenging activities as well as total phenolics and flavonoid contents of the extracts were measured. As primary screening of anti-inflammatory activity, cell viability and inhibition of nitric oxide (NO) production were determined using the lipopolysaccharide-treated RAW 264.7 macrophage cell line. The levels of phenolic and flavonoid compounds from AC were found to be 459 Ϯ 1 mg gallic acid equivalent/g (GAE/g) dry mass and 642 Ϯ 4 mg catechin equivalent/g (CE/g) dry mass, respectively. AC showed 2,2diphenyl-1-picrylhydrazyl 1,1-diphenyl-2-picrylhydrazyl, nitrite scavenging and hydroxyl radical-scavenging activity in a dose-dependent manner. Significant NO production and cell viability were also found in the extracts. Results suggest that AC can be a source of natural antioxidants and anti-inflammatory substances. PRACTICAL APPLICATIONSAsparagus cochinchinensis has been used in traditional Chinese medicine for over 2,000 years. Dried roots are being used for medicinal purposes. The roots contain asparagine, starch, mucilage and sugars. The dried root is antibacterial, antiinflammatory, antiseptic, antipyretic, diuretic, expectorant, stomachic, nervous stimulant and tonic. It is taken internally in the treatment of fever, sore throat, debility, coughs, etc. The plant has a folk history for the treatment of cancer. Modern research has detected antitumor activity. It is now being studied for the treatment of lung cancer. The findings of this study can demonstrate the antioxidant and anti-inflammatory activities of the aqueous extract from A. cochinchinensis dried roots. The effects would be useful to improve human health. bs_bs_banner Journal of Food Biochemistry

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

Phenolic Contents, Antioxidant and Anti-inflammatory Activities of Asparagus cochinchinensis (Loureiro) Merrill

Samad

Debnath

Hasnat

et al. 2013

Journal of Food Biochemistry

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“…ramulosa Wedd., a native shrub of Chile commonly called “checal”, “tolilla” or “tola-checal”. The genus Fabiana (Solanaceae family) grows in South America, especially along arid mountainous area between 16° and 51° latitude and between 1 000 and 4 900 m over sea level, featuring needlelike leaves and profuse tiny tubular flowers. , This genus comprises 15 species: ten are present in Argentina, seven in Chile, four in Bolivia and one in Perú. However, the latest revision of the vascular flora of Chile indicates a total of eight species of the Fabiana genus, including F. densa J. Remy .…”

Section: Resultsmentioning

confidence: 99%

Structural Elucidation and Antimicrobial Characterization of Novel Diterpenoids from Fabiana densa var. ramulosa

Quaglio

Corradi

Erazo

et al. 2020

ACS Med. Chem. Lett.

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Novel diterpenoids were isolated from the extracts of Fabiana densa var. ramulosa and found to display a selective activity against Gram-positive bacterial strains with negligible cytotoxicity toward human keratinocytes. This study highlighted the role played by the acidic group at C18 of the tetracyclic ent-beyerene scaffold for antibacterial effects and how the length and flexibility of the alkyl chain between the two carbonyl groups are crucial factors to increase the antimicrobial activity of the molecules, supporting the development of natural products from F. densa and their derivatives for treatment of microbial infections.

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“…Results were expressed as mg gallic acid equivalents in 100 g of the dried extract (mg GAE/100 g). The total flavonoid content of the extract or fraction was determined as follows [22]. Briefly, to 0.1 mL of sample, 2.35 mL methanol and 50 µ L of 5% AlCl 3 ethanolic solution were added.…”

Section: Methodsmentioning

confidence: 99%

Protective Mechanisms ofS. lycopersicumAqueous Fraction (Nucleosides and Flavonoids) on Platelet Activation and Thrombus Formation:In Vitro,Ex VivoandIn VivoStudies

Fuentes

Pereira

Alarcón

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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The purpose of this research was to investigate mechanisms of antiplatelet action of bioactive principle from S. lycopersicum. Aqueous fraction had a high content of nucleosides (adenosine, guanosine, and adenosine 5′-monophosphate) by HPLC analysis. Also aqueous fraction presented flavonoids content. Aqueous fraction inhibited platelet activation by 15 ± 6% (P < 0.05). Fully spread of human platelets on collagen in the presence of aqueous fraction was inhibited from 15 ± 1 to 9 ± 1 μm2 (P < 0.001). After incubation of whole blood with aqueous fraction, the platelet coverage was inhibited by 55 ± 12% (P < 0.001). Platelet ATP secretion and aggregation were significantly inhibited by the aqueous fraction. At the same concentrations that aqueous fraction inhibits platelet aggregation, levels of sCD40L significantly decreased and the intraplatelet cAMP levels increased. In addition, SQ22536, an adenylate cyclase inhibitor, attenuated the effect of aqueous fraction toward ADP-induced platelet aggregation and intraplatelet level of cAMP. Platelet aggregation ex vivo (human study) and thrombosis formation in vivo (murine model) were inhibited by aqueous fraction. Finally, aqueous fraction may be used as a functional ingredient adding antiplatelet activities (nucleosides and flavonoids) to processed foods.

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Comparative study of antioxidant and anti-inflammatory activities and genotoxicity of alcoholic and aqueous extracts of four Fabiana species that grow in mountainous area of Argentina

Cited by 17 publications

References 31 publications

Phenolic Contents, Antioxidant and Anti-inflammatory Activities of Asparagus cochinchinensis (Loureiro) Merrill

Phenolic Contents, Antioxidant and Anti-inflammatory Activities of Asparagus cochinchinensis (Loureiro) Merrill

Structural Elucidation and Antimicrobial Characterization of Novel Diterpenoids from Fabiana densa var. ramulosa

Protective Mechanisms ofS. lycopersicumAqueous Fraction (Nucleosides and Flavonoids) on Platelet Activation and Thrombus Formation:In Vitro,Ex VivoandIn VivoStudies

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