2018
DOI: 10.1016/j.taap.2018.07.014
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Comparative study of anti-VEGF Ranibizumab and Interleukin-6 receptor antagonist Tocilizumab in Adjuvant-induced Arthritis

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Cited by 24 publications
(11 citation statements)
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“…The effects on inflammatory, angiogenesis, apoptosis inhibition were observed in both groups. Interestingly, anti-VEGF reduces the bone and cartilage destruction compared to methotrexate or tocilizumab treatment [74]. Another anti-VEGF signaling agent, Ramucirumab, is a monoclonal antibody against the VEGFR2, and co-therapy with methotrexate showed synergistic effects in a RA experimental model.…”
Section: Vegf In Ramentioning
confidence: 99%
“…The effects on inflammatory, angiogenesis, apoptosis inhibition were observed in both groups. Interestingly, anti-VEGF reduces the bone and cartilage destruction compared to methotrexate or tocilizumab treatment [74]. Another anti-VEGF signaling agent, Ramucirumab, is a monoclonal antibody against the VEGFR2, and co-therapy with methotrexate showed synergistic effects in a RA experimental model.…”
Section: Vegf In Ramentioning
confidence: 99%
“…We selected adjuvant-induced arthritis (AIA) because it mimics the signs and symptoms of human RA, such as the histopathological changes of inflammation, vascular proliferation, and importantly, the progression to joint destruction [18]. The AIA model has been widely used in the development of antirheumatic drugs, including several non-steroid anti-inflammatories, methotrexate [19], and also biologic drugs, including tocilizumab [20] and Jak-inhibitors like tofacitinib [21].…”
Section: Introductionmentioning
confidence: 99%
“…COX-2 (PTGS2) is the rate-limiting enzyme of arachidonic acid metabolism, which controls the production of PGE 2 , the proin ammatory mediators of autoimmunity activities [25][26][27] . VEGF is an essential angiogenic marker for RA disorders [28][29][30] . TP53 and CASP3 regulate the apoptosis of rheumatoid synovial cells [31][32] .…”
Section: Network Pharmacology Unraveled Crucial Anti-ra Targets Of Geramentioning
confidence: 99%