Comparative Study of a Microporous Cholestyramine Analogue (Filicol) and Gemfibrozil for Treatment of Severe Primary Hypercholesterolemia

Ros, Emilio; Zambón, Daniel; Bertomeu, Antonia; Cusó, Eulalia; Sanllehy, C; Casals, Elena

doi:10.1001/archinte.1991.00400020059013

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…Podemos observar como ante la misma concentración de LDL en plasma, el poder aterogénico puede variar debido a la diferencia en el tamaño de la partícula. reducción de estos cocientes sería el principal predictor del beneficio del tratamiento de las dislipemias (36,197,229,243,315). Desafortunadamente, se requieren más estudios de intervención hipolipemiante no farmacológica, como el presentado en este trabajo, para conocer la relación entre los cambios lipídicos y el beneficio clínico obtenido tras la intervención.…”

Section: Cociente Ldl/apobunclassified

Análisis de los efectos de un programa nutricional y de ejercicio físico sobre el perfil lipídico en personas con sobrepeso y obesidad

Romero-Moraleda¹

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Section: Cociente Ldl/apobunclassified

Análisis de los efectos de un programa nutricional y de ejercicio físico sobre el perfil lipídico en personas con sobrepeso y obesidad

Romero-Moraleda¹

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Ion Exchange Resins

Schwandt¹,

Richter²

1994

Handbook of Experimental Pharmacology

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Effect of apolipoprotein E polymorphism on the serum lipid response to a hypolipidemic diet rich in monounsaturated fatty acids in patients with hypercholesterolemia and combined hyperlipidemia

Zambón

Ros

Casals

et al. 1995

The American Journal of Clinical Nutrition

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We investigated the effect of variation at the apolipoprotein (apo) E gene locus on the serum lipid response to a hypolipidemic diet rich in monounsaturated fatty acids (MUFA). Lipoprotein changes were assessed in 122 outpatients with type IIa (n = 70) and type IIb (n = 52) hyperlipidemia [80 men and 42 women with apo E phenotypes 3/2 (n = 27), 3/3 (n = 48), and 4/3 (n = 47)] who were switched from their basal diet containing 40% fat (22% MUFA) to an isoenergetic diet containing 31% fat (MUFA content similar to that of the basal diet) for 12 wk. Significant (P < 0.005) reductions of total, LDL, and VLDL cholesterol; triglycerides; and apo B occurred in subjects regardless of WHO phenotype. Triglycerides and VLDL cholesterol decreased more in type IIb than in type IIa subjects: 25% vs 12% and 21% vs 15%, respectively (P = 0.01). HDL cholesterol tended to decrease only in women. The heterogeneity of lipoprotein responses to dietary intervention was unrelated to apo E phenotypes. In these hyperlipidemic subjects, however, diet-induced favorable changes in serum lipoproteins were selectively influenced by WHO phenotype.

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Comparative Study of a Microporous Cholestyramine Analogue (Filicol) and Gemfibrozil for Treatment of Severe Primary Hypercholesterolemia

Cited by 4 publications

References 30 publications

Análisis de los efectos de un programa nutricional y de ejercicio físico sobre el perfil lipídico en personas con sobrepeso y obesidad

Análisis de los efectos de un programa nutricional y de ejercicio físico sobre el perfil lipídico en personas con sobrepeso y obesidad

Ion Exchange Resins

Effect of apolipoprotein E polymorphism on the serum lipid response to a hypolipidemic diet rich in monounsaturated fatty acids in patients with hypercholesterolemia and combined hyperlipidemia

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