Comparative Study of a Drug Release from a Textile to Skin

Radu, Cezar Doru; Parteni, Oana

doi:10.4172/2325-9604.1000134

Cited by 14 publications

(8 citation statements)

References 14 publications

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“…The influence of the textile substrate when used in combination with vehiculizers has been studied in previous cases with microencapsulated ibuprofen [38,48,107]. It is possible to modify the diffusion of the active agent and, furthermore, to indicate that textile supports show potential for use in systems of release [115,116].…”

Section: Resultsmentioning

confidence: 99%

Vehiculation of Active Principles as a Way to Create Smart and Biofunctional Textiles

et al. 2018

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In some specific fields of application (e.g., cosmetics, pharmacy), textile substrates need to incorporate sensible molecules (active principles) that can be affected if they are sprayed freely on the surface of fabrics. The effect is not controlled and sometimes this application is consequently neglected. Microencapsulation and functionalization using biocompatible vehicles and polymers has recently been demonstrated as an interesting way to avoid these problems. The use of defined structures (polymers) that protect the active principle allows controlled drug delivery and regulation of the dosing in every specific case. Many authors have studied the use of three different methodologies to incorporate active principles into textile substrates, and assessed their quantitative behavior. Citronella oil, as a natural insect repellent, has been vehicularized with two different protective substances; cyclodextrine (CD), which forms complexes with it, and microcapsules of gelatin-arabic gum. The retention capability of the complexes and microcapsules has been assessed using an in vitro experiment. Structural characteristics have been evaluated using thermogravimetric methods and microscopy. The results show very interesting long-term capability of dosing and promising applications for home use and on clothes in environmental conditions with the need to fight against insects. Ethyl hexyl methoxycinnamate (EHMC) and gallic acid (GA) have both been vehicularized using two liposomic-based structures: Internal wool lipids (IWL) and phosphatidylcholine (PC). They were applied on polyamide and cotton substrates and the delivery assessed. The amount of active principle in the different layers of skin was determined in vitro using a Franz-cell diffusion chamber. The results show many new possibilities for application in skin therapeutics. Biofunctional devices with controlled functionality can be built using textile substrates and vehicles. As has been demonstrated, their behavior can be assessed using in vitro methods that make extrapolation to their final applications possible.

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Section: Resultsmentioning

confidence: 99%

Vehiculation of Active Principles as a Way to Create Smart and Biofunctional Textiles

et al. 2018

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“…Cotton Antimicrobial Octenidine dihydrochloride [138] Silver [139,140] Phenolic compounds [76,141] Ketoconazole [115] ZnO, TiO2 and Ag nanoparticles [142] Miconazole nitrate [143] Triclosan [144] Fragrance, antimicrobial Essential Oils [74,145] Insect repellent Cypermethrin and Prallethrin [146] Nocturnal regulation of sleep and antioxidant properties Melatonin [77] For coetaneous affections Hydrocortisone acetate [147] Polyamide Perfume, moisturize and UV-protect. 2-ethoxynaphtalene (neroline) [119] Antibiotics Ciprofloxacin [148] Molecules 2020, 25, 3624 14 of 28 In this way, the application of CDs in fibrous polymers occurs.…”

Section: Effect Active Molecule Referencementioning

confidence: 99%

The Role of β-Cyclodextrin in the Textile Industry—Review

Bezerra

Arias²,

Firmino

et al. 2020

Molecules

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β-Cyclodextrin (β-CD) is an oligosaccharide composed of seven units of D-(+)-glucopyranose joined by α-1,4 bonds, which is obtained from starch. Its singular trunk conical shape organization, with a well-defined cavity, provides an adequate environment for several types of molecules to be included. Complexation changes the properties of the guest molecules and can increase their stability and bioavailability, protecting against degradation, and reducing their volatility. Thanks to its versatility, biocompatibility, and biodegradability, β-CD is widespread in many research and industrial applications. In this review, we summarize the role of β-CD and its derivatives in the textile industry. First, we present some general physicochemical characteristics, followed by its application in the areas of dyeing, finishing, and wastewater treatment. The review covers the role of β-CD as an auxiliary agent in dyeing, and as a matrix for dye adsorption until chemical modifications are applied as a finishing agent. Finally, new perspectives about its use in textiles, such as in smart materials for microbial control, are presented.

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Section: Drug Delivery Kineticsmentioning

confidence: 99%