Comparative study in photodynamic therapy using the same photosensitizer in tissue repair after second-degree burns in an experimental model

Santos, Kesia Maria Mangoni Gonçalves dos; Cordeiro, Maria Elvira Ribeiro; Pereira, Mário César da Silva; Barbosa, Danillo; Pezzini, André Alexandre; Kerppers, Ivo Ilvan

doi:10.1007/s41547-019-00081-8

Cited by 3 publications

(4 citation statements)

References 14 publications

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“…LED is a radiation of varying wavelength, not coherent and which is standing out in the field of medical treatment and phototherapy for being an alternative to the high cost of laser therapy [41]. The use of light with Low-intensity Laser Therapy or by Light-emitting Diode is called photobiomodulation [42] and among its functions, it is the stimulation of neural activity, that occurs through interaction with cytochrome c oxidase (unit IV of the mitochondrial electrons transport chain), which through a series of reactions, stimulates the ATP synthase enzyme to produce more ATP, improving brain function [27].…”

Section: Transcranial Photobiomodulationmentioning

confidence: 99%

“…Regarding the in vivo studies, the effects of resveratrol were already expressed and described in different ways, and among them the ones of note are reduction of amyloid load and inhibition of the amyloidogenic processing [37][38][39], neuroprotection of memory loss, cognitive improvement and acetylcholinesterase inhibition [38,39], anxiety reduction, increase on the AMPK levels [36,39], positive regulation of the SIRT1 path [37][38][39][40] and reversion of the damage on spatial memory [39,41].…”

Section: Resveratrolmentioning

confidence: 99%

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Therapeutic Approaches for Alzheimer’s Disease: New Perspectives

Kerppers¹,

Hosni²,

Miri³

et al. 2022

Amyloidosis - History and Perspectives

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Alzheimer’s disease (AD) was defined as a neurodegenerative disorder, being more affected in the elderly. It is estimated that every 3.2 seconds a person in the world is affected by the high disease that rate in 2050 to 1 second. Therefore, research has been carried out on new therapeutic approaches, such as Transcranial Photobiomodulation and treatment based on antioxidants, such as Resveratrol. Therefore, the objective is to conduct a literature review on these two approaches and their effects on the treatment of AD. It was carried out according to the PRISMA recommendation and the articles were selected according to the years of publication (between 2015 and 2020) and extracted from the following databases: Science Direct, PubMed PMC, Scopus, PubMed NCBI, SciELO, LILACS, MEDLINE and PEDro. In several studies it has been reported that both therapies provide improvements at the molecular and behavioral level, recovering brain functions, acting in a neuroprotective way, improving quality of life, with few adverse effects and in a less invasive way. Thus, both treatments have numerous benefits that can be useful in the treatment of AD. However, there is a need for further research that includes interventions with greater specificity and control, so that they are defined as ideal doses and treatment protocols.

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Section: Transcranial Photobiomodulationmentioning

confidence: 99%

Section: Resveratrolmentioning

confidence: 99%

Therapeutic Approaches for Alzheimer’s Disease: New Perspectives

Kerppers¹,

Hosni²,

Miri³

et al. 2022

Amyloidosis - History and Perspectives

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show abstract

“…The molecular mechanism of cell death in PDT depends on the PS accumulated dose [ 207 ], localization of the PS inside the cells or tumor compartments [ 208 , 209 ], PS mechanism of actions [ 162 ], oxygen availability [ 210 ], light dosage [ 211 ], type and places of post-ROS damages [ 212 ], cells, and tissue repair potential [ 213 ]. Such a mechanism can directly induce cancer cell death.…”

Section: Why Are Hyperthermia and Pdt Used In Treatment? Why Are They A Good Option For Combination Treatment?mentioning

confidence: 99%

Photodynamic Therapy and Hyperthermia in Combination Treatment—Neglected Forces in the Fight against Cancer

et al. 2021

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Cancer is one of the leading causes of death in humans. Despite the progress in cancer treatment, and an increase in the effectiveness of diagnostic methods, cancer is still highly lethal and very difficult to treat in many cases. Combination therapy, in the context of cancer treatment, seems to be a promising option that may allow minimizing treatment side effects and may have a significant impact on the cure. It may also increase the effectiveness of anti-cancer therapies. Moreover, combination treatment can significantly increase delivery of drugs to cancerous tissues. Photodynamic therapy and hyperthermia seem to be ideal examples that prove the effectiveness of combination therapy. These two kinds of therapy can kill cancer cells through different mechanisms and activate various signaling pathways. Both PDT and hyperthermia play significant roles in the perfusion of a tumor and the network of blood vessels wrapped around it. The main goal of combination therapy is to combine separate mechanisms of action that will make cancer cells more sensitive to a given therapeutic agent. Such an approach in treatment may contribute toward increasing its effectiveness, optimizing the cancer treatment process in the future.

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“…ANALGESIA As a precautionary measure, all animals received 50 mg/kg tramadol orally for 7 days at every 12 h dos Santos et al (2020).…”

Section: Light Emitting Diode (Led) Irradiationmentioning

confidence: 99%

Influence of 627 Nm Wavelength Light Emitting Diode Phototherapy on Secondary Intention Wound Healing

Suckow

Bini

Hosni

et al. 2021

Int. J. Res. Granthaalayah

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Background: The use of photobiomodulation can be effective in the healing of tissues, highlighting the use of LED in tissue repair. Was evaluated the effect of 627 nm wavelength LED irradiation on VEGF-α and TGF-β1 expressions in a model of secondary intention wound healing. Methods: The evaluations were performed using a dorsal puncture model and the sample consisted of 120 Wistar rats, randomly divided into LED groups submitted to 3, 7, 14 and 21 irradiation treatment for 100 s, 7 J / cm2, and control groups. Histological analysis, immunohistochemistry and contraction of the lesion were performed. Results: LED irradiation led to effective wound regeneration results. Similar effects were obtained with vascular, exudative, and proliferative phenomena. VEGF and TGF-β1 levels were increased in LED-treated groups with initial treatments. Collagen analysis revealed that LED-treated groups levels were increased on days 14- and 21 of the treatments. An acceleration in tissue regeneration was observed in LED treated groups. Macroscopically visible results showing a complete healing process was evident after 14 days of treatment. Conclusion: 627 nm LED irradiation effectively accelerated wound healing leading complete closure of the skin in a shorter time compared to control group.

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Comparative study in photodynamic therapy using the same photosensitizer in tissue repair after second-degree burns in an experimental model

Cited by 3 publications

References 14 publications

Therapeutic Approaches for Alzheimer’s Disease: New Perspectives

Therapeutic Approaches for Alzheimer’s Disease: New Perspectives

Photodynamic Therapy and Hyperthermia in Combination Treatment—Neglected Forces in the Fight against Cancer

Influence of 627 Nm Wavelength Light Emitting Diode Phototherapy on Secondary Intention Wound Healing

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