Comparative Study Between Standard Dressing with EUSOL and Topical Platelet Derived Growth Factor in Healing of Diabetic Foot Ulcer

Abstract

Background: Diabetic patients with foot ulcer constitute the majority of hospital admissions. Unless treated appropriately a worsening infection can set of a chain of events, a spreading infection which penetrates into the deep soft tissue excites cellulitis, produces necrosis and gangrene and eventually necessitates the amputation of limb. Management of established foot ulcer lesion is multidisciplinary and even demands expertise in surgery, endocrinology, podiatry, orthopedics, vascular surgery, neurology, infectious disease. Platelet-derived growth factor (PDGF) is one of the numerous growth factors that regulate cell growth and division, in particular angiogenesis. PDGF promote formation of granulation tissue and thus stimulate cutaneous ulcer healing. Methods: A study was conducted on 50 patients to compare the outcome and efficacy of topical PDGF v/s EUSOL in healing of diabetic foot ulcer. Result: 50 patients of diabetic of diabetic foot ulcer were studied, divided into two groups of 25 each. One group received PDGF and other group received EUSOL. It was observed that patient receiving PDGF had better wound contraction of 39.55% as compared to group receiving EUSOL in whom the mean wound contraction was 11.79%. Conclusion: PDGF dressing therapy in the treatment of diabetic foot ulcer was found to be more effective, safe, promoter of wound healing.

Comparing the Efficacy of Recombinant Human Platelet Derived Growth Factor (PDGF) Gel Dressing with Conventional Dressing in Emergency wound care in Maxillofacial Surgery

“…PDGF has been shown to be safe , reproducible and effective in mimicking the natural process of soft tissue wound healing as it stimulates the production and secretion of collagenase by fibroblast suggesting a role in the wound healing remodeling phase. 3 Platelet derived growth factor (PDGF) is an approximately 25KDa, a dimeric protein consisting of 2 disulfideconnected polypeptide chains. It is present in 3 different isoforms , the heterodimer PDGF-AB (consisting of an α and β chains) and 2 homodimers, with 2α or 2β chains (PDGF-AA and PDGF-BB, respectively).…”