Comparing the Efficacy of Recombinant Human Platelet Derived Growth Factor (PDGF) Gel Dressing with Conventional Dressing in Emergency wound care in Maxillofacial Surgery

Abstract

The importance of Platelet Derived Growth Factor is well established in wound healing cascade, its ability to stimulate cell migration, cell growth, and other development factors synthesis. We, therefore, performed a retrospective, randomized case-control trial to compare the effectiveness of recombinant human Platelet Derived Growth Factor(rhPDGF) gel dressing with traditional povidone iodine dressing in emergency wound care in maxillofacial surgery. Aim and objective: To evaluate the effectiveness and esthetic outcomes of rhPDGF gel dressing over the conventional dressing and to assess rhPDGF gel dressing as a better alternative to conventional dressing. Materials and methods: 40 subjects with acute lacerated wounds were included into the study and were randomly divided into two groups; Group A (study group ) consisted of subjects in whom rhPDGF gel dressing was placed over the wound with collagen. Group B(control group) consisted of subjects in whom conventional povidone iodine dressing was placed over the wound ; patients were clinically evaluated every week for a total of 4 weeks.The dressing was changed every 3 days or as required in both the groups following the same standard protocol. Clinical and photographic assessment of the wounds was done at every week's follow up visit. Results: The subjects in the study group showed superior wound healing and esthetic outcomes as compared to the control group , with a p value <0.001. The overall cosmesis was relatively more acceptable (35%) in the study group as compared to the control group(15%) at 1st week and during 2nd , 3rd, and 4th week , study group showed significantly increased mean overall wound healing score as compared to the control group at p = 0.04 , p =0.005 and p = 0.001 respectively. Conclusion: rhPDGF gel provides better wound healing and esthetic outcomes than conventional povidone iodine dressing .