Comparative study between natural and synthetic Hydroxyapatite: structural, morphological and bioactivity properties

Sossa, Paola Andrea Forero; Giraldo, Belarmino Segura; García, B.; Restrepo-Parra, E.; Arango, P.J.

doi:10.1590/s1517-707620180004.0551

Cited by 45 publications

(39 citation statements)

References 32 publications

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“…The BHAp powders were obtained according to the method reported elsewhere 24 . Briefly, the porcine bones were firstly hydrothermally treated to remove soft tissue and lipids.…”

Section: Methodsmentioning

confidence: 99%

“…Although the bioactive behavior of stoichiometric HAp and that of BHAp has been studied in different works, few studies have been found that present the evaluation of samples’ bioactive behavior, obtained from porcine bone as a function of the calcination temperature. Thus, this work aims to study the temperature treatment effect (from 900 to 1200 °C) on the BHAp samples in the bioactive response 24 . The bioactivity test was performed following Kokubo’s methodology and using ISO 23317: 2014 standard 25 .…”

Section: Introductionmentioning

confidence: 99%

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Temperature effect in physicochemical and bioactive behavior of biogenic hydroxyapatite obtained from porcine bones

Forero-Sossa

Salazar-Martinez

Giraldo-Betancur

et al. 2021

Sci Rep

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Biogenic hydroxyapatite (BHAp) is a widely used material in the biomedical area due to its similarities with the bone tissue mineral phase. Several works have been spotlighted on the thermal behavior of bone. However, little research has focused on determining the influence of calcination temperature in the physicochemical and bioactive properties of BHAp. In this work, a study of the physicochemical properties’ changes and bioactive response of BHAp produced from porcine femur bones using calcination temperatures between 900 to 1200 °C was conducted. The samples’ structural, morphological, and compositional changes were determined using XRD, SEM, and FTIR techniques. XRD results identified three temperature ranges, in which there are structural changes in BHAp samples and the presence of additional phases. Moreover, FTIR results corroborated that B-type substitution is promoted by increasing the heat treatment temperature. Likewise, samples were immersed in a simulated biological fluid (SBF), following the methodology described by Kokubo and using ISO 23317:2014 standard, for 3 and 7 days. FTIR and SEM results determined that the highest reaction velocity was reached for samples above 1000 °C, due to intensity increasing of phosphate and carbonate bands and bone-like apatite morphologies, compared to other temperatures evaluated.

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“…The BHAp powders were obtained according to the method reported elsewhere 24 . Briefly, the porcine bones were firstly hydrothermally treated to remove soft tissue and lipids.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Temperature effect in physicochemical and bioactive behavior of biogenic hydroxyapatite obtained from porcine bones

Forero-Sossa

Salazar-Martinez

Giraldo-Betancur

et al. 2021

Sci Rep

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“…Figure 5(c) shows Ti6Al4V alloy coated with HAP after sintering which revealed that there was an enhanced linkage and the interconnection of HAP powders that exist on the coated surface morphology [51]. Figure 5(d) shows the HAP coated on Ti6Al4V after the immersion in SBF [52].…”

Section: Microstructuresmentioning

confidence: 97%

Facile Coating of HAP on Ti6Al4V for Osseointegration

Asrar

Tufail

Chandio

2021

Eng. Technol. Appl. Sci. Res.

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Ti6Al4V alloy is a material with great strength, low-slung modulus, inferior density, and a virtuous blend of mechanical and exceptional corrosion resistance. However, it does not offer good osseointegration and bone development properties. Conversely, hydroxyapatite (HAP) is highly bioactive in nature to bind with the nearby bone tissues when implanted in the host body. In this work, we have extracted HAP from bovine bones by using the thermal decomposition method. This was followed by its deposition onto the Ti6Al4V alloy using the Electrophoretic Deposition (EPD) technique. TiO2 is used as a bond coat layer to increase the adhesion between HAP and Ti6Al4V alloy substrates. The coated samples after sintering exhibited excellent adhesion. This was followed by characterization using Scanning Electron Microscopy (SEM) and Fourier Transformed Infrared Spectroscopy (FTIR). FTIR and SEM confirm the formation of HAP and its presence after the immersion in SBF. Vicker hardness tester confirms the increase in hardness value of coated samples up to 35%. Potentiostat tests were conducted to compare the corrosion rate of both samples. In addition, the particle sizes were also identified by a laser particle analyzer, whereas X-Ray Diffraction (XRD) technique was also used to determine the crystalline phases of alloy and HAP.

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“…The presence of PO 4 3at 961 cm -1 is attributed to symmetric stretching. Carbonate (CO 3 ) -can also be present in HAp depending on the synthetic routes [9,58] which is generally found intense in bio-derived HAp whereas weaker in synthetic HAp [58,60].…”

Section: -mentioning

confidence: 99%

An Overview of Synthesis Based Biomedical Applications of Hydroxyapatite Nanomaterials

Bhandari

Bista

Gautam

et al. 2021

J. Nepal Chem. Soc.

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Hydroxyapatite (HAp) is the mineral phase of animal bones embedded in a collagen-containing organic matrix. It is a naturally optimized material for the physical support of the bones. Synthetic Hydroxyapatite based biomaterials, hence, find wide applications in orthopedics, dentistry, and tissue engineering due to their biocompatibility, bioactivity, osteoconductivity, and similar chemical composition to that of HAp present in animal bones. Different physicochemical synthetic methods and natural biogenic sources have been reported for the synthesis of nano-hydroxyapatite. However, particle size, aspect ratio, and the distribution of HAp in biomaterials have significant effects to use as bone substitutes and implants. This paper has summarized some synthetic methods of preparing nano-HAp from different biogenic approaches. Further, it focuses on some facile synthetic routes of preparing nano-HAp with controlled particle size with higher crystallinity and native bone architectures. This review article aims to correlate some simplistic and cost-effective biosynthetic approaches of nano-HAp, their size-dependent properties characterization, and biomedical applications.

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Comparative study between natural and synthetic Hydroxyapatite: structural, morphological and bioactivity properties

Cited by 45 publications

References 32 publications

Temperature effect in physicochemical and bioactive behavior of biogenic hydroxyapatite obtained from porcine bones

Temperature effect in physicochemical and bioactive behavior of biogenic hydroxyapatite obtained from porcine bones

Facile Coating of HAP on Ti6Al4V for Osseointegration

An Overview of Synthesis Based Biomedical Applications of Hydroxyapatite Nanomaterials

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