“…The highest fluorescence intensities for both, 2-AP and 3-AP were obtained at pH 3.0. The obtained results were in good agreement with those obtained by previously published results 23 . Figure 3 Effect of pH of 10 mM B-R buffer on the fluorescence intensities of 2-AP and 3-AP (50.0 ng/mL).…”
Section: Resultssupporting
confidence: 92%
“…2-AP and 3-AP are efficient fluorophores as a result of (π-π * ) nature of the lowest excited state 23 . Meanwhile, the cited drugs (PX, TX, ALO and LIN) are not or very weakly fluorescent compounds 24 – 27 , therefore, 2-AP and 3-AP can be determined quantitatively without any interference from these drugs.…”
A green spectrofluorimetric method was introduced for the determination of selected genotoxic impurities; 2-aminopyridine and 3-aminopyridine in different pharmaceutical raw materials and dosage forms. The method relied on the native fluorescence of these impurities in acidic medium. The experimental conditions were carefully studied and optimized, and the method was validated according to International Council on Harmonisation (ICH) guidelines. The linear range for both analytes was 2.50–100 ng/mL with good determination coefficients of 0.9995 and 0.9992 and detection limits of 0.62 ng/mL and 0.74 ng/mL for 2-aminopyridine and 3-aminopyridine, respectively. The method was successfully applied for determination of 2-aminopyridine and 3-aminopyridine in four active pharmaceutical ingredients and nine dosage forms with satisfactory percentage recoveries and without interference from co-formulated excipients. Analytical performance of the proposed method was comparable to that of the reported methods; hence, the proposed method can be used as a simple and low-cost alternative in quality control laboratories.
“…The highest fluorescence intensities for both, 2-AP and 3-AP were obtained at pH 3.0. The obtained results were in good agreement with those obtained by previously published results 23 . Figure 3 Effect of pH of 10 mM B-R buffer on the fluorescence intensities of 2-AP and 3-AP (50.0 ng/mL).…”
Section: Resultssupporting
confidence: 92%
“…2-AP and 3-AP are efficient fluorophores as a result of (π-π * ) nature of the lowest excited state 23 . Meanwhile, the cited drugs (PX, TX, ALO and LIN) are not or very weakly fluorescent compounds 24 – 27 , therefore, 2-AP and 3-AP can be determined quantitatively without any interference from these drugs.…”
A green spectrofluorimetric method was introduced for the determination of selected genotoxic impurities; 2-aminopyridine and 3-aminopyridine in different pharmaceutical raw materials and dosage forms. The method relied on the native fluorescence of these impurities in acidic medium. The experimental conditions were carefully studied and optimized, and the method was validated according to International Council on Harmonisation (ICH) guidelines. The linear range for both analytes was 2.50–100 ng/mL with good determination coefficients of 0.9995 and 0.9992 and detection limits of 0.62 ng/mL and 0.74 ng/mL for 2-aminopyridine and 3-aminopyridine, respectively. The method was successfully applied for determination of 2-aminopyridine and 3-aminopyridine in four active pharmaceutical ingredients and nine dosage forms with satisfactory percentage recoveries and without interference from co-formulated excipients. Analytical performance of the proposed method was comparable to that of the reported methods; hence, the proposed method can be used as a simple and low-cost alternative in quality control laboratories.
“…(3)). It was found that single amino substitution (14) was sufficient to induce an efficient fluorescence (364.5 nm, = 0.46) and, interestingly, asymmetrically substituted 6-amino-6'-chloro bpy (15) had a much larger quantum yield ( = 0.79) even though fluorescence was observed in a region similar to that of 13 and 14 [36]. These compounds also showed notable blue luminescence in the solid state.…”
Section: -1 Ring Substitutionmentioning
confidence: 99%
“…Nevertheless, there are appreciable numbers of pyridine derivatives that show efficient fluorescence (Chart (1)). In the late 1960s, 2-aminopyridine (5) and 3-aminopyridine (6) were reported to exhibit an efficient fluorescence at 352 nm ( =0.37) and 359 nm ( =0.23), respectively, in ethanol, while 4-aminopyridine (7) did not show any fluorescence [13] [14]. 2-Aminopyridine (5) has been used as a fluorescent marker for saccharides [15], glycosaminoglycans [16] and a standard compound for determining fluorescence quantum yield [17], but its applications are rather limited because its absorption and fluorescence appear not in the visible but in the UV region.…”
Oligopyridines connected through the 2-and 6-positions have long been the subject of continuing interest because of their high ability to interact with metal ions and/or other molecules, and their transition-metal complexes have been intensely studied for decades because of their characteristic photophysical properties. However, relatively few have been known in regard to the photophysical and photo-functional properties of oligopyridine derivatives. From the late 1990s, fluorescent oligopyridines have been of considerable interest as tunable fluorophores by intermolecular interaction, and the design and synthesis of novel oligopyridine derivatives and their application to fluorescent sensors has increasingly been studied. In this article, we will review recent developments of fluorescent oligopyridines and their photo-functionality.
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