Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin) and Nigella damascena L. (Lady-in-a-Mist) Seeds

Toma, Claudia Crina; Oláh, Neli-Kinga; Vlase, Laurian; Mogoşan, Cristina; Mocan, Andrei

doi:10.3390/molecules20069560

Cited by 93 publications

(98 citation statements)

References 34 publications

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“…The Na + /K + ratio can predict the nature of the diuretic mechanism 16. A Na + /K + ratio of >1 indicates a satisfactory diuresis without excessive urinary potassium loss 17.…”

Section: Discussionmentioning

confidence: 99%

Diuretic activity of the aqueous crude extract and solvent fractions of the leaves of <em>Thymus serrulatus</em> in mice

Melka¹,

Makonnen²,

Debella³

et al. 2016

JEP

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The present study was undertaken to investigate the diuretic activity and acute toxicity profile of the crude aqueous extract and solvent fraction of the leaves of Thymus serrulatus in saline-loaded Swiss albino mice. Mice of either sex were divided into six groups (five animals in each group). The control group received normal saline (25 mL/kg), while the reference group received hydrochlorothiazide (10 mg/kg). Group III to Group VI received the test substances at dose levels of 125, 250, 500, and 1,000 mg/kg orally, respectively. At the end of the fifth hour, urine was collected, and total volume of urine excreted by each animal was recorded. Concentrations of urinary Na+ and K+ were determined, and the Na+/K+ ratio was calculated to make comparison among the groups. The acute toxicity of the most active fraction was also evaluated. The findings demonstrated that the crude aqueous extract of T. serrulatus leaves showed significant diuretic (P<0.01), natriuretic (P<0.01), and kaliuretic (P<0.01) effects. At the dose of 1,000 mg/kg, the n-butanol fraction demonstrated the highest diuretic activity comparable to the reference drug. It also showed a good natriuretic activity. The dichloromethane fraction, however, did not have significant diuretic activity. Both the crude aqueous extract of the leaves of T. serrulatus and its n-butanol fraction have diuretic activity with high concentration of urinary electrolytes in mice. Further studies, however, need to be pursued on the possible mechanism(s) of diuretic action.

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“…The Na + /K + ratio can predict the nature of the diuretic mechanism 16. A Na + /K + ratio of >1 indicates a satisfactory diuresis without excessive urinary potassium loss 17.…”

Section: Discussionmentioning

confidence: 99%

Diuretic activity of the aqueous crude extract and solvent fractions of the leaves of <em>Thymus serrulatus</em> in mice

Melka¹,

Makonnen²,

Debella³

et al. 2016

JEP

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show abstract

“…The free radical scavenging ability of the UAE methanolic extracts of fresh and thermally processed samples was measured according to a previously reported method [43,44]. A BIOTEK spectrometer (515 nm) (BioTek®Instruments, Inc., Winooski, VT, USA) was used to monitor the reaction between DPPH and antioxidant compounds present in the samples.…”

Section: Dpph Free Radical Scavenging Capacitymentioning

confidence: 99%

Thermal Processing for the Release of Phenolic Compounds from Wheat and Oat Bran

Călinoiu

Vodnar

2019

Biomolecules

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The aim of the present paper was to identify the major polyphenolic compounds and investigate the antioxidant, antimutagenic, and antimicrobial activities of industrially-derived cereal byproducts-wheat bran (WB) and oat bran (OB)-before (fresh) and after thermal processing (TP) (10 min, 80 • C), coupled with ultrasound-asssited extraction. The results showed that the thermal process improved the total phenolic content of WB by +22.49%, and of OB with +25.84%. After the TP, the phenolic concentration showed a significant relative percentage increase in the case of WB (ferulic acid +39.18%, vanillic acid +95.68%, apigenin-glucoside +71.96%, p-coumaric acid +71.91) and of OB (avenanthramide 2c +52.17%, dihydroxybenzoic acids +38.55%). The best antioxidant capacity was registered by OBTP followed by WBTP. The strongest antimicrobial inhibition was attributed to the WBTP sample. Both thermally processed matrices had strong antimutagenic activity toward S. typhimurium TA100. This thermal processing was tested on bran based on its practical application within the food industry, considering the design of different cereal byproducts derived from functional foods and nutraceuticals.

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“…DPPH free-radical-scavenging assay Using the method described by Toma et al, (2015) the phenolic extracts of fresh and thermally processed samples were subject to DPPH radicalscavenging activity assessment. The percentage inhibition (I%) was calculated as [1-(test sample absorbance/blank sample absorbance)]x100.…”

Section: Analysis Of Phenolic Compounds By Hplc-dad-esi-msmentioning

confidence: 99%

Characterization of Grape and Apple Peel Wastes’ Bioactive Compounds and Their Increased Bioavailability After Exposure to Thermal Process

Călinoiu¹,

Mitrea²,

Precup³

et al. 2017

BUASVMCN-FST

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ABSTRACT80% of the grape harvest is used in the winemaking industry, resulting in huge amounts of waste which are still rich in phenolic compounds, while the same percentage of polyphenols are found in apple peel, whose total antioxidant capacity is five-to-six-fold higher than that of apple flesh. The aim of this research is the characterization of grape and apple peels waste, before and after the thermal treatment (10 minutes, 80°C), with respect to its bioactive compounds to evaluate their potential enhancement with respect to bioavailability. Based on the obtained results, the highest antioxidant activity and phenolic content was exhibited by thermally processed redgrape waste. After the thermal treatment, the caffeic acid 4-O-glucoside increased with a 27% in apple waste. As a conclusion, the grape and apple peels waste can be exploited for their bioactive compounds after the thermal process, whose bioavailability increased and can be added in food formulations as health promoting products.

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Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin) and Nigella damascena L. (Lady-in-a-Mist) Seeds

Cited by 93 publications

References 34 publications

Diuretic activity of the aqueous crude extract and solvent fractions of the leaves of <em>Thymus serrulatus</em> in mice

Diuretic activity of the aqueous crude extract and solvent fractions of the leaves of <em>Thymus serrulatus</em> in mice

Thermal Processing for the Release of Phenolic Compounds from Wheat and Oat Bran

Characterization of Grape and Apple Peel Wastes’ Bioactive Compounds and Their Increased Bioavailability After Exposure to Thermal Process

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