To study the response of yield and its components and grains quality of some maize genotypes to foliar spraying, two field experiments were carried out at the Experimental Station Farm, Faculty of Agriculture,, Egypt, during the 2017 and 2018 seasons. Each experiment was carried out in a strip-plot design with four replications. The vertical-plots were assigned with maize genotypes i.e. Three Way Cross 324, Single Cross 128, and Single Cross 131. The horizontal-plots were occupied with foliar spraying treatments i.e. without, foliar spraying with; commercial fertilizer Fert-plus powder, amino acids, yeast extract, and the mixture Fert-plus powder + amino acids + yeast extract. The results showed that genotype 131 surpassed other studied genotype and recorded 100-grain weight, grain yield/ha, and total carbohydrates percentage in grains in both seasons. genotype 128 registered the tallest plants and the highest values of stover yield/ha and crude protein and oil percentages in grains in both seasons. Foliar spraying maize plants three times with the mixture treatment produced the highest values of growth, yields and its attributes and grains quality characters followed by, yeast extract then commercial fertilizer Fert-plus powder as a source of NPK and amino acids in both seasons. It can be concluded that foliar fertilizing maize genotype 131 or 128 with the mixture Fert-plus powder at the rate of 4 g/liter + amino acids at the rate of 2.5 ml/liter + yeast extract at the rate of 100 ml/liter water in each spraying in order to maximize productivity and grains quality under the environmental conditions of the research area.