Comparative studies on micromechanical properties and biological performances in hydroxyapatite ceramics with micro/nanocrystalline

Wu, Yonghao; Cao, Quanle; Niu, Mingyou; Feng, Cong; Li, Xiangfeng; Zhu, Xiangdong; Zhang, Xingdong

doi:10.1111/jace.18087

Cited by 4 publications

(1 citation statement)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Researchers have conducted a wide range of studies addressing this issue. Wu [ 15 ] found that nano-HA ceramics could decrease the hardness and fracture toughness of HA ceramics with an increase in crystallinity. First-principles and molecular dynamics simulations were used by Shang [ 16 ] to study HA’s crystal structure and adsorption capacity for macromolecular drugs; it was found that Zn-doping effectively improved the binding energy between doxorubicin (DOX) and HA.…”

Section: Introductionmentioning

confidence: 99%

First-Principles Computational Study of the Modification Mechanism of Graphene/Graphene Oxide on Hydroxyapatite

et al. 2022

View full text Add to dashboard Cite

Due to its unique crystal structure and nano-properties, hydroxyapatite (HA) has become an important inorganic material with broad development prospects in electrical materials, for fire resistance and insulation, and in bone repair. However, its application is limited to some extent because of its low strength, brittleness and other shortcomings. Graphene (G) and its derivative graphene oxide (GO) are well known for their excellent mechanical properties, and are widely used to modify HA by domestic and foreign scholars, who expect to achieve better reinforcement and toughening effects. However, the enhancement mechanism has not been made clear. Accordingly, in this study, G and GO were selected to modify HA using the first-principles calculation method to explore the theory of interfacial bonding of composites and explain the microscopic mechanism of interfacial bonding. First-principles calculation is a powerful tool used to solve experimental and theoretical problems and predict the structure and properties of new materials with precise control at the atomic level. Therefore, the bonding behaviors of hydroxyapatite (100), (110) and (111) crystal planes with G or GO were comprehensively and systematically studied using first-principles calculation; this included analyses of the density of states and differential charge density, and calculations of interfacial adhesion work and elastic moduli. Compared to HA (100) and (111) crystal planes, HA (110) had the best bonding performance with G and with GO, as revealed by the calculation results. The composite material systems of HA (110)/G and HA (110)/GO had the smallest density of states at the Fermi level, the largest charge transfers of Ca atoms, the largest interfacial adhesion work and the most outstanding elastic moduli. These results provide a theoretical basis for the modification of HA to a certain extent, and are beneficial to the expansion of the scope of its application.

show abstract

Section: Introductionmentioning

confidence: 99%

First-Principles Computational Study of the Modification Mechanism of Graphene/Graphene Oxide on Hydroxyapatite

et al. 2022

View full text Add to dashboard Cite

show abstract

Bone‐on‐a‐Chip: A Microscale 3D Biomimetic Model to Study Bone Regeneration

et al. 2022

View full text Add to dashboard Cite

Organ‐on‐chip models, developed using microengineering and microfluidic technologies, aim to recreate physiological‐like microenvironments of organs or tissues as a tool to study (patho)physiological processes in vitro. On‐chip models of bone are relevant for the study of bone physiology, diseases and regenerative processes. While a few bone‐on‐a‐chip models exist, recapitulating the cellular components of bone, these models do not incorporate the chemical and structural characteristics of bone tissue. Herein, the development of a bone‐on‐a‐chip platform is reported that comprises a 3D structural model of bone. To build the platform, first, a 3D model of bone is produced in a polymer using two‐photon polymerization (2PP) from a 3D nano‐computed tomography scan of trabecular bone. This 3D model is then coated with a layer of bone mineral‐like calcium phosphate. Finally, the 3D bone model is integrated inside a microfluidic device suitable for cell culture. Human mesenchymal stromal cells, cultured inside the platform for up to 21 days, show high viability and extensive production of extracellular matrix, rich in collagen. This biomimetic bone‐on‐a‐chip platform can contribute to a better understanding of the processes related to bone formation and remodeling, which in turn can be used for the development of bone regeneration strategies.

show abstract

A Novel Hollow‐Tube‐Biphasic‐Whisker‐Modified Calcium Phosphate Ceramics with Simultaneously Enhanced Mechanical Strength and Osteogenic Activity

Feng

et al. 2022

Adv Funct Materials

View full text Add to dashboard Cite

Due to the inherent brittleness and low mechanical strength, it is still a challenge for calcium phosphate (Ca-P) ceramics to be used in load-bearing bone defect repair. To achieve a good balance between mechanical strength and osteogenic activity, hollow-tube-whisker-modified biphasic calcium phosphate (BCP) ceramics (BCP-HW) are successfully fabricated by an in situ growth process in the present study. Compared to the initial BCP ceramics (BCP-C) and those with solid whiskers, BCP-HW exhibits larger specific surface area (3.9 times vs BCP-C) and higher mechanical strength (3.4 times vs BCP-C), endowing it with stronger stimulation on adhesion, proliferation, and osteogenic differentiation of bone marrow mesenchymal stem cells. In an intramuscular implantation model of canine, BCP-HW shows excellent osteoinductivity and promotes the maturation of new bone, and the resultant compressive strength of the implant increases to ≈12 MPa at 3 months postoperatively. In another critical-sized segmental bone defect model of rabbit femur, BCP-HW has the best repairing effect. After implantation for 6 months, much more new bone ingrowth and higher bending load are observed in BCP-HW than BCP-C. Collectively, these findings suggest that the in situ hollow-tube whisker construction possesses immense potential in expanding the applications of Ca-P ceramics to load-bearing bone defect repair.

show abstract

Comparative studies on micromechanical properties and biological performances in hydroxyapatite ceramics with micro/nanocrystalline

Cited by 4 publications

References 60 publications

First-Principles Computational Study of the Modification Mechanism of Graphene/Graphene Oxide on Hydroxyapatite

First-Principles Computational Study of the Modification Mechanism of Graphene/Graphene Oxide on Hydroxyapatite

Bone‐on‐a‐Chip: A Microscale 3D Biomimetic Model to Study Bone Regeneration

A Novel Hollow‐Tube‐Biphasic‐Whisker‐Modified Calcium Phosphate Ceramics with Simultaneously Enhanced Mechanical Strength and Osteogenic Activity

Contact Info

Product

Resources

About