Comparative Studies of Diplococci Decolorized by Gram's Method, Obtained from the Spinal Fluid and from the Nares of Cases of Epidemic Cerebrospinal Meningitis

On Variations of the Meningococcus and its Differentiation from Other Cocci Occurring in the Cerebro-Spinal Fluid

“…Goodwin and Sholly (1906) found that the agglutinating power of serum prepared by injecting meningococci varied much from day to day, and Dunham (1906) failed to obtain a serum of high agglutinating power. Kutscher (1906) describes a strain of meningococcus agglutinated macroscopically by a specific horse serum, at 55a C., but not at 370 C.…”

On the Occurrence of the Micrococcus catarrhalis in Normal and Catarrhal Noses and its Differentiation from other Gram-negative Cocci

“…A few occurrences have been, however, recorded apart from obvious meningitis infection by Schiff (1898), Weichselbaum and Ghon (1905), and others. Dunham (1906) examined cultures from the nose and throat of 16 persons suffering from epidemic meningitis, and in six found an organism resembling the meningococcus in every respect, including agglutination. Goodwin and Sholly (1906) examined the noses of 55 healthy persons not in contact with meningitis cases, and on two occasions isolated an organism which resembled the meningococcus in its cultural characteristics, but differed from it in its agglutinating properties.…”

“…F. W. Andrewes (1906) adds dextrin and laevulose to those carbohydrates from which acid is formed by the meningococcus. Dunham (1906), using litmus-glucose-serum-broth found that the meningococcus piroduced acid but no coagulation, and that catarrhalislike organisms either caused no acidity or produced acid and also caused coaguilation of the medium, whereas M. catarrhalis caused neither acidity nor coagulation.…”

“…Specific aggluitination as a means of differentiation has proved of value as regards several kinds of Gram-negative organisms, but M. catarrhalis and somie of the other species ag,glutinate spontaneously. Dunham (1906), Goodmiian andSholly (1906), v. Lingelsheim (1906), and others have prepared meningococcus sera and have successfully used their agglutinating action to separate organisms otherwise indistinguishable from the meningococcus. v. Lingelsheim also prepared a M. catarrhalis serum which did not agglutinate the meningococcus.…”

Beitrag zur Züchtung und Biologie der Meningokokken

“….Naeh A. Bettencourt und C. FranCa 1904 (5) war in Neutralrot-Traubenzucker-Schriigagar keine Farbenveranderung zu erkennen, wahrend ungefiihr gleichzeitig E. K Dunham(9) in Dextrose-Serum-Bouillon Siiuerung, M. E.Goodwin und A. I. v. Shol/y (18) a uf-Schafserumagar Zerlegung der Dextrose und Maltose, auffallenderweise auch der Laktose, abet keine der Saccharose wie des Mannit beobaehtete und K. H. Kutseher (26 und 27) wie Bru ns und Hoh n (6) eine Siiuerung anf Maltose und Dextrose, aber nicht bei Liivulosezusatz feststellten. .Naeh A. Bettencourt und C. FranCa 1904 (5) war in Neutralrot-Traubenzucker-Schriigagar keine Farbenveranderung zu erkennen, wahrend ungefiihr gleichzeitig E. K Dunham(9) in Dextrose-Serum-Bouillon Siiuerung, M. E.Goodwin und A. I. v. Shol/y (18) a uf-Schafserumagar Zerlegung der Dextrose und Maltose, auffallenderweise auch der Laktose, abet keine der Saccharose wie des Mannit beobaehtete und K. H. Kutseher (26 und 27) wie Bru ns und Hoh n (6) eine Siiuerung anf Maltose und Dextrose, aber nicht bei Liivulosezusatz feststellten.…”