Comparative Stability of Cephalothin and Cefazolin in Buffer or Human Serum

Pitkin, Donald; Actor, Paul; Filan, J.; White, Roderick E.; Weisbach, Jerry A.

doi:10.1128/aac.12.2.284

Cited by 7 publications

(4 citation statements)

References 2 publications

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“…For instance, Qureshi et al (2013) reported that at 25°C, the CXM that remained in a deionized water solution was approximately 70% of the initial concentration after 30 h. However, the remaining proportion of CXM in the investigated CPWW eff was approximately 85% at 25°C after 30 h. The varied degradation rates of cephalosporins in different kinds of solutions have also been reported by other scholars (Glaria et al, 2003;Pitkin et al, 1977). This phenomenon could be explained by different ingredients in the solution, which might catalyze or inhibit the degradation of cephalosporins in different mediums.…”

Section: Effect Of Temperature On the Persistence Of Cephalosporins Isupporting

confidence: 61%

Distribution and persistence of cephalosporins in cephalosporin producing wastewater using SPE and UPLC–MS/MS method

Tang

Zuo

et al. 2016

Science of The Total Environment

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Section: Effect Of Temperature On the Persistence Of Cephalosporins Isupporting

confidence: 61%

Distribution and persistence of cephalosporins in cephalosporin producing wastewater using SPE and UPLC–MS/MS method

Tang

Zuo

et al. 2016

Science of The Total Environment

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“…All urine samples were frozen until analyzed. Although cefazolin is more stable than other cephalosporins, 14 care was taken to chill samples immediately on collection. Serum was centrifuged and then frozen until analyzed.…”

Section: Methodsmentioning

confidence: 99%

Effect of cardiopulmonary bypass on cefazolin disposition

Miller

McCoy

Chan

et al. 1980

Clin Pharmacol Ther

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Cefazolin kinetics was studied in 8 patients the day before (PREOP), during (SURG), and the day after (POSTOP) cardiopulmonary bypass (CPB) surgery. PREOP (48.6 ml/min) and POSTOP (46.6 ml/min) total body clearances were of the same order and both were greater than the SURG (27.4 ml/min) total body clearance. Since cefazolin is almost entirely eliminated by the kidney, the lower SURG clearance is a result of reduced renal elimination, as confirmed by measuring cefazolin SURG (28.7 ml/min) and POSTOP (52.9 ml/min) renal clearance. The reduction in cefazolin renal elimination was the same throughout the surgical procedure, including the period of extracorporeal circulation. Cefazolin distribution was altered by the operative procedure as evidence by a higher SURG steady-state volume of distribution. This increase in apparent cefazolin distribution volume brought about by surgery was not seen with cephalothin, which was investigated by us in a similar group of patients. The different effect of CPB surgery on cefazolin and cephalothin distribution may be due to differences in plasma protein binding.

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“…All urine samples were frozen until analysis. Since cephalothin quickly loses activity at body and room temperatures, 17 care was taken to chill samples immediately on collection. Serum was centrifuged and then frozen until analysis.…”

Section: Methodsmentioning

confidence: 99%

Cephalothin kinetics: Before, during, and after cardiopulmonary bypass surgery

Miller

Chan

McCoy

et al. 1979

Clin Pharma and Therapeutics

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Cephalothin kinetics was studied in 5 patients the day before (PREOP), during (SURG), and the day after (POSTOP) cardiopulmonary bypass surgery. The PREOP (114 ml/min) and SURG (94 ml/min) renal clearances were of the same order but both were less than POSTOP renal clearance (248 ml/min). Cephalothin total body clearance during operation was lower (p less than 0.01) than PREOP or POSTOP clearance, with decreased metabolic clearance the primary cause. There was reduction in cephalothin elimination throughout the surgical procedure, not only in the period of extracorporeal circulation, indicating that general anesthesia had a significant influence on drug disposition. The metabolite deacetylcephalothin was rapidly formed on all 3 days and its kinetic behavior paralleled that of the parent drug.

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Comparative Stability of Cephalothin and Cefazolin in Buffer or Human Serum

Abstract: A marked loss in potency was observed when cephalothin was incubated for 5 h in human serum at 37°C. Cefazolin was stable under these conditions.

Cited by 7 publications

References 2 publications

Distribution and persistence of cephalosporins in cephalosporin producing wastewater using SPE and UPLC–MS/MS method

Distribution and persistence of cephalosporins in cephalosporin producing wastewater using SPE and UPLC–MS/MS method

Effect of cardiopulmonary bypass on cefazolin disposition

Cephalothin kinetics: Before, during, and after cardiopulmonary bypass surgery

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