Comparative serum biochemical changes in mongrel dogs following single and mixed infections of Trypanosoma congolense and Trypanosoma brucei brucei

Ezeokonkwo, R.C.; Ezeh, Ikenna O.; Onunkwo, J. I.; Onyenwe, I. W.; Iheagwam, Chijioke N.; Agu, W.E.

doi:10.1016/j.vetpar.2012.05.012

Cited by 19 publications

(21 citation statements)

References 16 publications

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“…The elevated creatinine level in the T. brucei-infected rats agrees with previous findings [39,43] and could be due to destruction of kidney cells resulting in the inability of the kidneys to excrete creatinine [43] . The decrease in creatinine levels when rats were given fraction 2c indicated that the ability of the fraction to provide some degree of protection to the kidneys during the course of the disease [11] .…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Anti–trypanosomal effect of Peristrophe bicalyculata extract on Trypanosoma brucei brucei–infected rats

Abimbola

Baba

Yenusa

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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Section: Discussionsupporting

confidence: 91%

“…The high levels of total bilirubin in infected rats in this experiment supports earlier observations in several trypanosome-infected animals [41][42][43] . The increase in bilirubin is suggestive of haemolytic anaemia which may be due to the activity of proliferating parasites.…”

Section: Discussionsupporting

confidence: 91%

Anti–trypanosomal effect of Peristrophe bicalyculata extract on Trypanosoma brucei brucei–infected rats

Abimbola

Baba

Yenusa

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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“…In dogs normal values for AST and ALT are between 1-37 U/L and ALT-3-50 U/L [2,13] and according to Hines [14] -5-55 U/L and 5-107 U/L, respectively. Ezeokonkwo et al [15] show that infection (parasitic) in dogs caused a significant increase in the activities of AST and ALT on day 7, which coincides with our study. According to Quinn et al [4] , liver enzyme activities (AST, ALT) showed only mild to moderate increases during bacterial infection in dogs.…”

Section: Tablo 3 Subkutan Inokulasyon Sonrası Zamana Bağlı Olarak Sasupporting

confidence: 92%

Köpeklerde Deneysel Oluşturulan Staphylococcus aureus Enfeksiyonunda Aspartat ve Alanin Aminotransferaz Aktivitelerindeki Değişimler

Zapryanova¹,

Rusenova²,

Beev³

et al. 2014

Kafkas Univ Vet Fak Derg

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SummaryThe main purpose of this study was to evaluate the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) plasma concentrations in dogs with experimentally-induced Staphylococcus aureus infection. Correlations between AST, ALT and Respiratory Rate (RR), Pulse Rate (PR) and Internal Body Temperature (IBT) were also calculated. Bacterial suspension with density of 3.1x10 9 cfu/mL was subcutaneously injected to 9 mongrel 2 years old male dogs whereas 6 other dogs served as negative controls. The concentrations were determined using commercial kits before application (0 h), 6, 24, 48, 72 h and 7, 14, 21 days after. The aminotransferase concentrations were higher in infected dogs than in the controls -AST peaked on days 7 and 14, and ALT -at the 72 nd h. Strong positive correlations were recorded between ALT and AST concentrations and between RR and IBT. It was observed that the transaminases activities were slightly affected by the experimentally induced staphylococcal infection in dogs. Keywords: Staphylococcus aureus, AST, ALT, Clinical signs, Dogs Köpeklerde Deneysel Oluşturulan Staphylococcus aureus Enfeksiyonunda Aspartat ve Alanin Aminotransferaz Aktivitelerindeki Değişimler ÖzetBu çalışmanın amacı köpeklerde deneysel Staphylococcus aureus enfeksiyonunda aspartat aminotransferaz (AST) ve alanin aminotransferaz (ALT) plazma knosantrasyonlarını değerlendirmektir. AST, ALT ve solunum oranı (RR), nabız oranı (PR) ve vücut iç sıcaklığı (IBT) arasındaki ilişki ayrıca değerlendirildi. Bakteri süspansiyonu (of 3.1x10 9 cfu/mL) 9 adet melez 2 yaşlı erkek köpeğe subkutan yolla enjekte edilirken 6 adet diğer köpek negatif kontrol olarak kullanıldı. Konsantrasyonlar 0, 6, 24, 48 ve 72 saat ile 7, 14, 21. günlerde uygulamadan önce ticari kitler kullanılmak suretiyle belirlendi. Aminotrasferaz konsantrasyonları kontrole oranla enfekte köpeklerde daha yüksekti. AST 7. ve 14. günlerde, ALT ise 72. saatte en yüksek konsantrasyonlarda belirlendi. ALT ile AST konsantrasyonları arasında ve RR ile IBT arasında güçlü ilişki belirlendi. Transaminaz aktivitelerinin köpeklerde deneysel olarak oluşturulan Syafilokokal enfeksiyonu ile az derecede etkilendiği gözlemlendi.

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“…These changes are associated with some organ damages and monitoring of these changes after treatment could be helpful in prediction of treatment outcome and effectiveness of treatment. Increase in the ALT activity in T. b. brucei infection has been reported by various authors (Ezeokonkwo et al, 2012). In this study, expectedly, ALT activity was elevated in infected untreated rats by 14 days post infection.…”

Section: Discussionsupporting

confidence: 75%

Chemotherapeutic efficacy of secnidazole-diminazene aceturate combination therapy in experimental Trypanosoma brucei brucei infection in rats

Eke¹,

Ezeh²,

Ezeudu³

et al. 2017

Afr. J. Pharm. Pharmacol.

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The chemotherapeutic efficacy of secnidazole-diminazene aceturate (SEC-DA) combination therapy was studied in rats experimentally infected with Trypanosoma brucei brucei with a view of eliminating relapse of infection. Twenty rats grouped into 4 groups (n = 5) were used for the study as follows: uninfected untreated (A), infected untreated (B), infected and treated with diminazene (DA) (3.5 mg/kg) alone intraperitoneum (IP) once (C), infected and treated with SEC (200 mg/kg, orally) + DA (3.5 mg/kg, IP) (D). Treatment started 8 days post-infection. Parasites disappeared from the blood of the SEC-DA treated rats after 3 days of treatment against 5 days for DA alone. Relapse infection occurred in DA alone, 13 days post-treatment. There was no relapse infection in the SEC-DA-treated rats up to 70 days post-treatment. Hematological profiles of the animals after treatment showed significantly (p < 0.05) higher total leucocytes, lymphocytes and neutrophil in the SEC-DA group when compared with DAtreated group. Significant (p < 0.05) increase in the hemoglobin concentration and a decrease in the alanine transaminase (ALT) activity were also observed in the SEC-DA group as compared to the DA alone treated group. It is concluded therefore that the SEC-DA combination therapy was more efficacious than DA alone.

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Comparative serum biochemical changes in mongrel dogs following single and mixed infections of Trypanosoma congolense and Trypanosoma brucei brucei

Cited by 19 publications

References 16 publications

Anti–trypanosomal effect of Peristrophe bicalyculata extract on Trypanosoma brucei brucei–infected rats

Anti–trypanosomal effect of Peristrophe bicalyculata extract on Trypanosoma brucei brucei–infected rats

Köpeklerde Deneysel Oluşturulan Staphylococcus aureus Enfeksiyonunda Aspartat ve Alanin Aminotransferaz Aktivitelerindeki Değişimler

Chemotherapeutic efficacy of secnidazole-diminazene aceturate combination therapy in experimental Trypanosoma brucei brucei infection in rats

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