Anti–trypanosomal effect of Peristrophe bicalyculata extract on Trypanosoma brucei brucei–infected rats

Abimbola, Abdulazeez Mansurah; Baba, Ibrahim Abdulrazak; Yenusa, Edibo Zakari; Omanibe, Sidali Joseph; Oladimeji, Idris Habeeb

doi:10.1016/s2221-1691(13)60107-0

Cited by 24 publications

(10 citation statements)

References 26 publications

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“…The difference in the types of anaemia may be attributed to many factors, including stage of the disease, pathogenicity of trypanosomes and host species [7]. Trypanosomosis is fatal if left untreated, and chemotherapy, which remains the main form of control and eradication of the disease in African countries, is associated with toxicity and increasing incidence of resistance among the trypanosomes to the existing drugs [8,9]. Thus, the search for new drugs and formulations, which are safe, affordable and effective against both early and late stages of the disease, has been recommended [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…Trypanosomosis is fatal if left untreated, and chemotherapy, which remains the main form of control and eradication of the disease in African countries, is associated with toxicity and increasing incidence of resistance among the trypanosomes to the existing drugs [8,9]. Thus, the search for new drugs and formulations, which are safe, affordable and effective against both early and late stages of the disease, has been recommended [9][10][11]. Flavonoids are effective and common antioxidants, possessing many pharmacological activities [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Haematological Changes in Trypanosoma brucei brucei Infected Wistar Rats Treated with a Flavonoid Mixture and/or Diminazene Aceturate

Pi¹,

Ayo²,

Aluwong³

et al. 2014

Biol Med (Aligarh)

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The aim of the study was to evaluate the effect of treatment with DAFLON® 500 mg (DF) and/or diminazene aceturate (DZ) on hematological parameters in rats, infected with Trypanosoma brucei brucei. Rats in the control group were administered with distilled water (DW) only (5 mL/kg), while those in other groups were infected with Trypanosoma brucei brucei (10 6 cells/ml), and treated with DF and/or DZ. Packed cell volume (PCV), haemoglobin (Hb) concentration, erythrocyte (RBC) and neutrophil counts were lower in the infected untreated and DF-treated group, than in any other group. Total leucocyte, lymphocyte, platelet counts and mean corpuscular volume (MCV) decreased in the infected untreated group, compared to values obtained in those administered with DF and/or DZ. The MCV reduced in the DZ-treated group, compared to the groups treated with DF and the combination of DF and DZ. Mean corpuscular haemoglobin concentration (MCHC) was lower in the infected untreated and DF treated group than in the DW or DZ group. Rats administered with DZ had higher leucocyte and lymphocyte counts compared to those in DF-treated group. It is concluded that the administration of DF and/or DZ ameliorated the anaemia caused by Trypanosoma brucei brucei -infection in Wistar rats.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Haematological Changes in Trypanosoma brucei brucei Infected Wistar Rats Treated with a Flavonoid Mixture and/or Diminazene Aceturate

Pi¹,

Ayo²,

Aluwong³

et al. 2014

Biol Med (Aligarh)

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“…The plant species selected for screening were based on the observed published literatures on chemical constituent's evaluation as either little or absent. This procedure were carried out on the Methanol extract according to (Abimbola et al, 2013;Evans, 2009)…”

Section: Preliminary Phytochemical Screeningmentioning

confidence: 99%

Evaluation of phytochemicals and anti-inflammatory effects on methanol extracts of <i>Aeschynomene uniflora</i>

Anas¹,

Ambi²,

Zainab³

et al. 2019

Bayero J. Pure App. Sci.

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, +2348030427519, +2348076308928 ABSTRACTS Studies on Aeschynomene uniflora was carried out with the aim to establish scientific validation by evaluating the phytochemical constituents, toxicity and anti-inflammatory effects of the Methanol extract in order to probe its ethnomedical uses. Various phytochemical constituents from the plant were evaluated using standard method which reveals the presence of carbohydrates, cardiac glycoside, flavonoids, saponins, steroids, triterpenes and tannins were present in the crude extract. Toxicity studies by using oral route showed no death in any group even at 5000 mg/ kg indicating its safety. Antiinflammatory effects indicates its efficacy in which the dose at 1000 mg/kg showed more activity compared to Control followed by 250 mg/kg and then 500 mg/kg. The results obtained in this present study indicates the plant to have the potential to act as a source of useful drugs because of the presence of various primary and secondary metabolites .The results were very much encouraging but more scientific validation is necessary before being put into practice.

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“…50 mg/kg of Cold water whole plant extract of P. bicalyculata immobilized 90% of T. b. brucei in vitro after one hour of incubation, while the methanol extract of the plant showed a dose-dependent suppressive property in mice infected with T . evansi [35,36]. Nok and Williams described that the extract obtained from Allium sativum (Amaryllidaceae) completely eliminated trypanosomes in mice on administering 120 mg/kg live weight at 4 days post-treatment.…”

Section: Acanthaceae Amaryllidaceae Anacardiaceae Annonaceae Amentioning

confidence: 99%

Anti-Trypanosomal Activity of Nigerian Plants and Their Constituents

et al. 2015

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African trypanosomiasis is a vector-borne parasitic disease causing serious risks to the lives of about 60 million people and 48 million cattle globally. Nigerian medicinal plants are known to contain a large variety of chemical structures and some of the plant extracts have been screened for antitrypanosomal activity, in the search for potential new drugs against the illness. We surveyed the literatures on plants and plant-derived products with antitrypanosomal activity from Nigerian flora published from 1990 to 2014. About 90 plants were identified, with 54 compounds as potential active agents and presented by plant families in alphabetical order. This review indicates that the Nigerian flora may be suitable as a starting point in searching for new and more efficient trypanocidal molecules.

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Anti–trypanosomal effect of Peristrophe bicalyculata extract on Trypanosoma brucei brucei–infected rats

Cited by 24 publications

References 26 publications

Haematological Changes in Trypanosoma brucei brucei Infected Wistar Rats Treated with a Flavonoid Mixture and/or Diminazene Aceturate

Haematological Changes in Trypanosoma brucei brucei Infected Wistar Rats Treated with a Flavonoid Mixture and/or Diminazene Aceturate

Evaluation of phytochemicals and anti-inflammatory effects on methanol extracts of <i>Aeschynomene uniflora</i>

Anti-Trypanosomal Activity of Nigerian Plants and Their Constituents

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