Anti-Trypanosomal Activity of Nigerian Plants and  Their Constituents

Nwodo, Ngozi Justina; Ibezim, Akachukwu; Ntie‐Kang, Fidele; Adikwu, M. U.; Mbah, Chika J

doi:10.3390/molecules20057750

Cited by 57 publications

(39 citation statements)

References 87 publications

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“…Some of these classes of compounds detected in the plant extracts used in this work have been shown to exhibit antitrypanosomal activities. With the exception of saponins which have been shown not to have antitrypanosomal actions [12], flavonoids are known to possess significant antitrypanosomal actions [13,14]. Therefore, the action of the extracts in eliminating or reducing the parasite motility may be due to the actions of flavonoids which are present in the extracts used in this study.…”

Section: Determination Of Parasitaemiamentioning

confidence: 96%

In Vitro Study of Antitrypanosomal Activity of Ethanolic Leaf Extract of Garcinia Kola Against Trypanosoma Brucei Brucei

Sani

Zakariyya²,

Mahé³

et al. 2018

Asian J Pharm Clin Res

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Objective: The study was aimed at evaluating in vitro antitrypanosomal activity of Garcinia kola against Trypanosoma brucei brucei. Methods:The plant materials were extracted and screened for phytochemicals. The antitrypanosomal activity of 70% and 100% G. kola extracts against the parasite was determined in vitro.Results: Both extracts contained saponins, tannins, carbohydrates, cardiac glycosides, and flavonoids. However, anthraquinones and alkaloids were undetected. The parasites were seen to be actively motile within the first 30 min post-incubation period in 70% hydroethanolic G. kola extract and were found dead at 40-60 min in a higher concentration of extract. After 10 min post-incubation of the parasites in 100% ethanolic extract of G. kola, the parasites were observed to be active at lower concentration but at higher concentrations of the extracts, no trypanosomes were seen. Conclusion:100% extract induces ceasing of motility at the lesser time compared to 70% ethanolic extract. Similarly, the effect increases with increase in extract concentration. Further research should be carried out to elucidate the bioactive compounds present to have a broad knowledge on the mode of action of the compounds.

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Section: Determination Of Parasitaemiamentioning

confidence: 96%

In Vitro Study of Antitrypanosomal Activity of Ethanolic Leaf Extract of Garcinia Kola Against Trypanosoma Brucei Brucei

Sani

Zakariyya²,

Mahé³

et al. 2018

Asian J Pharm Clin Res

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“…[55][56][57][58][59][60][61][62][63][64][65][66][67] It is our goal to provide evidence of the efficacy and potency of plants used in traditional medicine against protozoal infections. The systematic documentation of the plant-based chemical constituents of African traditional medicine and attempting to using in silico procedures to investigate their modes of action are ongoing efforts, [44][45][46]52,53 particularly on the isolated compounds from African medicinal plants (AMPs) with evaluated in vitro and/or in vivo activities against trypanosomiasis, [68][69][70][71][72][73][74] schistosomiasis, leishmaniasis 73,74 and other parasitic protozoal diseases. 4 However, the most recent review dates about 3 years back and was focused only on plants collected from Nigeria.…”

Section: Introductionmentioning

confidence: 99%

Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Cv¹,

Ntie‐Kang²,

Sh.³

et al. 2018

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An absolute configuration of 5R seems to decrease activity of the compound IntroductionProtozoa may be considered as microscopic, essentially single-celled, eukaryotic organisms that are free-living or parasitic (obtaining their food by eating other organisms or their products) in nature. Parasitic protozoal diseases continue to be a cause of considerable morbidity and mortality globally. 1,2Parasitic protozoal diseases include malaria, 3,4 trypanosomiasis (African sleeping sickness and Chagas disease), 5-7 leishmaniasis 8 and schistosomiasis. 9,10 They threaten almost one-third of the world's population, the most numerous incidents being recorded in over 100 Tropical and developing countries and territories, Figure 1. 11,12 Malaria, for example, was reported by the WHO, to be responsible for approximately 214 million sickness cases and 438,000 deaths globally in 2017. 13 The African region recorded the most death-related cases, especially amongst infants below the age of 5 and pregnant women. Schistosomiasis, caused by parasites of the Schistosoma genus are responsible for about 200 million sickness cases and about 280,000 death-related incidents annually worldwide.9,10,14 Only one drug (praziquantel) has been proven to be effective in the treatment of human schistosomiasis, with no vaccine available or in development so far.15-21 Serious concerns about drug selectivity and resistance were raised in 2013 when over 30 million people were treated in Sub-Saharan Africa. 20 Moreover, observed resistance and reduced efficiency of praziquantel in laboratory strains have prompted the search for alternative therapeutic strategies. Trypanosomiasis, which represents several diseases caused by parasites of the genus Trypanosoma, is also of interest. 5,27,29 This disease, which is much arguably the most important disease of man and domesticated animals, accounts for over 8 million reported annual cases globally, especially in the tropical regions of Latin America and Africa. 30,31 Although the present number of cases seems negligible on a worldwide scale, great socioeconomic effects on the endemic areas by this disease are forecast if inadequate attention (both at the communal, national, and international levels) is not given. 7,29,[32][33][34] Leishmaniasis is caused by parasites of the Leishmania type, which is also transmitted by certain types of sandflies. 35,36 The diseases are reported by the WHO to be responsible for about 1 million new cases leading to approximately 30,000 deaths annually on a global scale. The major cause is linked to environmental changes A R T I C L E I N F O A B S T R A C TArticle history:English abstract: Parasitic diseases continue represent a threat on a global scale, particularly among the poorest countries in the world. This is particularly because of the absence of vaccines, and in some cases, resistance against available drugs, currently being used for their treatment. In this review emphasis is laid on natural products and scaffolds from African medicinal plants (AMPs) for lead drug di...

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“…proposed to assay the antitrypanosomal activity of this plant, in particular as some related 8 species, such as Magnifera indica and Spondias mombim, exhibit antitrypanosomal effects 9 (Nwodo et al, 2015). 10…”

Section: Antitrypanosomal Activitymentioning

confidence: 99%

In vitro antimalarial, antitrypanosomal and HIV-1 integrase inhibitory activities of two Cameroonian medicinal plants: Antrocaryon klaineanum (Anacardiaceae) and Diospyros conocarpa (Ebenaceae)

Fouokeng¹,

Feusso²,

Teinkela³

et al. 2019

South African Journal of Botany

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Anti-Trypanosomal Activity of Nigerian Plants and Their Constituents

Cited by 57 publications

References 87 publications

In Vitro Study of Antitrypanosomal Activity of Ethanolic Leaf Extract of Garcinia Kola Against Trypanosoma Brucei Brucei

In Vitro Study of Antitrypanosomal Activity of Ethanolic Leaf Extract of Garcinia Kola Against Trypanosoma Brucei Brucei

Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

In vitro antimalarial, antitrypanosomal and HIV-1 integrase inhibitory activities of two Cameroonian medicinal plants: Antrocaryon klaineanum (Anacardiaceae) and Diospyros conocarpa (Ebenaceae)

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