Comparative phytochemical study of various extracts from Limonium gmelinii

Zhussupova, A. I.; Ikhsanov, Y.S.; Kasymova, D; Zhusupova, G. Е.

doi:10.1055/s-0039-3399873

Cited by 1 publication

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“…In particular, ash, insoluble in 10% HCl, is represented mainly by SiO 2 and characterizes the contamination of raw materials with mineral impurities. The studied plants comply with the basic requirements for medicinal plant raw material by the State Pharmacopeia of the Republic of Kazakhstan (SP RK) [ 3 , 33 , 34 , 35 ], Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…When evaluating and standardizing medicinal plant raw material, wherever possible, quantitative analysis of biologically active and/or extractive compounds is also included [ 3 , 33 , 34 , 35 ]. The phytochemical analysis ( Table 2 ) showed the presence of hydrophobic compounds, amino acids, polysaccharides, and a significant number of phenolic compounds, particularly flavonoids, tannins and phenolic acids.…”

Section: Resultsmentioning

confidence: 99%

“…There are some parameters which need to be considered for the procurement of such, including their biological safety, absence of allergic and cumulative properties, therapeutic activity and value, their availability in the territory of the country, conditions of cultivation, complexity and profitability of technology for obtaining complexes of biologically active compounds (BAC) on their basis as well as preservation of ecosystem uniqueness during their procurement [ 3 ]. Based on the results of in-depth literature review on all of the aforesaid parameters, the above is true for plants of the genus Salvia (sage) of the Lamiaceae family.…”

Section: Introductionmentioning

confidence: 99%

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Immunomodulatory Effects of Plant Extracts from Salvia deserta Schang. and Salvia sclarea L.

Zhussupova

Zhumaliyeva

Ogay

et al. 2022

Plants

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Medicines, their safety, effectiveness and quality are indispensable factors of national security, important on a global scale. The COVID-19 pandemic has once again emphasized the importance of improving the immune response of the body in the face of severe viral infections. Plants from the Salvia L. genus have long been used in traditional medicine for treatment of inflammatory processes, parasitic diseases, bacterial and viral infections. The aim of the current study was to evaluate the immunomodulatory effects of plant extracts LS-1, LS-2 from Salvia deserta Schang. and LS-3, LS-4 from Salvia sclarea L. plants growing in southern Kazakhstan by conventional and ultrasonic-assisted extraction, respectively. The cytotoxic effects of the named sage extracts on neonatal human dermal fibroblasts (HDFn) were evaluated using the MTT assay. Immunomodulatory effects of the studied extracts were compared by examining their influence on pro-inflammatory cytokine secretion and phagocytic activity of murine immune cells. Depending on the physiological state of the innate immune cells, sage extracts LS-2 and LS-3 had either a stimulating effect on inactivated macrophages or suppressed cytokine-producing activity in LPS-activated macrophages. The greatest increase in TNF-α secretion was found after treatment of spleen T lymphocytes with sage extract LS-2, obtained by ultrasonic-assisted extraction.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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