Comparative pharmacokinetics of sulfamethazine after intravenous administration in bovine (<i>Bos taurus</i>) and buffalo (<i>Bubalis bubalis</i>) calves

Baroni, E.; Díaz, Diego C.; Picco, E.; Rubio, M.; Rodríguez, C.; Boggio, Juan Carlos; Andrés, M. I. San

doi:10.1111/j.1365-2885.2007.00839.x

Cited by 4 publications

(5 citation statements)

References 13 publications

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“…Sulfamethazine is classified as a long-acting sulphonamide (Spoo and Riviere 2001), but in our work, sulfamethazine plasma concentrations remains above 50 μg/mL for 21.38± 2.21 h; 21.20±3.3 h; 15.63±2.16; 14.45±3.23 h in one, three, seven and fifteen-week-old calves, respectively; therefore, sulfamethazine behaved as an intermediate-acting sulphonamide in all age groups. Our results are similar to those reported by Srivastava et al (1989), Pulido et al (1998) and Baroni et al (2007).…”

Section: Discussionsupporting

confidence: 95%

“…The value of V ss is similar to those previously described in ruminant species (Witkamp et al 1992;Witkamp et al 1992;Bulgin et al 1991;Baroni et al 2007). In our study, V ss did not differ significantly among different age groups, which is in agreement with the results obtained by Nouws et al (1989) in calves of 12 and 18 weeks old.…”

Section: Discussionsupporting

confidence: 83%

“…The pharmacokinetic behavior of sulfamethazine in adult ruminant species is characterized by a high bioavailability, a low volume of distribution (0.24-0.50 l/kg) and a relatively short elimination half-life, compared to other sulphonamides, which varies between 3 and 10 h (Mody and Malik 1997;Spoo and Riviere 2001;Baroni et al 2007).…”

Section: Introductionmentioning

confidence: 98%

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Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle

et al. 2008

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Sulphonamides are still being used widely, influenced by the low cost and the efficacy against many common bacterial infections, since they present a broad spectrum of activity. The aim of this study was to determine the effect of age on the pharmacokinetic/pharmacodynamics (PK/PD) integration of intravenous sulfamethazine (60 mg/kgbw) in cattle, and the possible therapeutic outcomes. Six healthy female calves, at the age of one, three, seven and fifteen weeks were used. Normality analysis was assessed with the Shapiro-Wilk test. Non-parametric tests for paired data were used. Plasma concentrations were quantified using HPLC/uv. Differences were found between one-three-weeks-old calves and seven-fifteen-weeks-old calves, in pharmacokinetic parameters (clearance, area under the concentration-time curve and elimination half-life) and in the PK/PD integration. The ratios obtained in PK/PD integration (T>MIC, WAUC) confirm that it is necessary to apply twice the dose of sulfamethazine in > or = 7 weeks-old cattle to reach a satisfactory dosage regimen (MIC > or = 32 microg/mL).

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Section: Discussionsupporting

confidence: 95%

Section: Discussionsupporting

confidence: 83%

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Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle

et al. 2008

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“…It was concluded that the astute clinician must be alert to a significant number of variable pharmacokinetic factors that could influence the response to antimicrobial treatment and closely monitor each patient to ensure the desired outcome is attained. While interspecies PK differences are well known (18), a recent example of unpredictable, unexpected and fatal intraspecies variability highlights the importance of monitoring the response to treatment and investigating untoward outcomes. Fatal intoxication of pigs administered valnemulin was experienced in Denmark in 1999 and 2000.…”

Section: Variationmentioning

confidence: 99%

Use of antimicrobial agents in livestock

Page¹,

Gautier²

2012

Rev. Sci. Tech. OIE

194

181

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Antimicrobial agents, especially antibacterial agents, are used throughout the world, across a diverse array of extensive and intensive livestock production systems, to protect the health and welfare of livestock and to improve their performance. While some agents that are used in livestock belong to classes that have no counterpart in human medicine, this is not the case for the most widely used agents: the tetracyclines, penicillins, macrolides and sulphonamides. Many bacterial diseases of livestock cause devastating losses of animal life and productivity. As a result, their keepers can lose their livelihoods and see a dramatic reduction in income, so there is often a great sense of urgency to treat affected animals early. However, there are a large number of bacterial pathogens that cause disease and it is frequently difficult to reach a conclusive diagnosis prior to instituting treatment. There are many ways in which existing uses of antimicrobial agents can be improved, amongst the most important are increased utilisation of veterinary professional services, the introduction of enhanced infection control measures, improved point-of-care diagnostic tests, and the application of physiologically based population pharmacokinetic-pharmacodynamic modelling.

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“…These included HPLC-UV [5][6][7][8][9][10][11], LC-MS [11][12][13][14][15][16] and LC-MS/MS [11,16,17] for pharmacokinetic studies of veterinary samples and determination in pharmaceuticals and food products. Quantification of low concentrations of sulfonamides in complex matrices is common in many fields, including analysis of trace levels in foodstuffs [18,19], biological and environmental monitoring [20,21] and pharmacokinetic studies [22,23]. When sample throughput is an important parameter, such as in pharmacokinetic applications, the development of rugged methods with short analysis times becomes an important consideration [24,25].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of sulfamethoxazole and trimethoprim in biological fluids for high-throughput analysis: Comparison of HPLC with ultraviolet and tandem mass spectrometric detection

Bedor¹,

Gonçalves²,

Ferreira³

et al. 2008

Journal of Chromatography B

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Comparative pharmacokinetics of sulfamethazine after intravenous administration in bovine (Bos taurus) and buffalo (Bubalis bubalis) calves

Cited by 4 publications

References 13 publications

Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle

Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle

Use of antimicrobial agents in livestock

Simultaneous determination of sulfamethoxazole and trimethoprim in biological fluids for high-throughput analysis: Comparison of HPLC with ultraviolet and tandem mass spectrometric detection

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