Comparative pharmacokinetics of paclitaxel after oral administration of Taxus yunnanensis extract and pure paclitaxel to rats

Simultaneous determination and pharmacokinetic study of Atractylenolide I, II and III in rat plasma after intragastric administration of Baizhufuling extract and Atractylodis extract by UPLC–MS/MS

“…The coexisting constituents in the Baizhufuling extract, such as, triterpene acids [29], might play an important role for the improvement of bioavailability of Atractylenolide I, II and III. The similar pharmacokinetic results appeared in some TCM study [30][31][32]. It is coincident with the theory of "synergistic effects".…”

Simultaneous determination of seven taxoids in rat plasma by UPLC–MS/MS and pharmacokinetic study after oral administration of Taxus yunnanensis extracts

“…It was found that the crude extract of twigs and leaves of Taxus are found to inhibit the growth of several human carcinoma xenografts after oral administration to mice [12]. In our previous research, we found that the C max and AUC 0−∞ of paclitaxel in rats were significantly higher in the T. yunnanensis extract treated group than those in pure paclitaxel treated group [13]. In addition to paclitaxel, some other taxoids such as cephalomannine, also exerted strong cytotoxicity to cancer cells [3,9,10,14,15].…”

Application of Combination High‐Throughput Phenotypic Screening and Target Identification Methods for the Discovery of Natural Product‐Based Combination Drugs

“…The authors also found that the improved efficacy may have been due to enterohepatic recirculation and hence increased bioavailability of the whole extract, suggesting that the pharmacokinetic profile was improved by the combination intrinsic to ginger . Another example is a study that compared administering isolated paclitaxel, which is a first‐line chemotherapeutic drug for breast and ovarian cancer, to administering paclitaxel in extract form along with other constituents from the twigs and leaves of the yew species, Taxus yunnanensis . The extract was found to increase the bioavailability and effectiveness of the drug when it was administered orally to rats .…”

“…Another example is a study that compared administering isolated paclitaxel, which is a first‐line chemotherapeutic drug for breast and ovarian cancer, to administering paclitaxel in extract form along with other constituents from the twigs and leaves of the yew species, Taxus yunnanensis . The extract was found to increase the bioavailability and effectiveness of the drug when it was administered orally to rats . Paclitaxel typically has a low oral bioavailability and must be administered intravenously, in part because it is a good substrate of the efflux transporter P‐gp, which limits the tissue penetration of the drug .…”

“…The extract was found to increase the bioavailability and effectiveness of the drug when it was administered orally to rats . Paclitaxel typically has a low oral bioavailability and must be administered intravenously, in part because it is a good substrate of the efflux transporter P‐gp, which limits the tissue penetration of the drug . However, multiple compounds isolated from the Taxus species have been shown to inhibit the activities of P‐gp, which suggests that potentially nonactive constituents in the whole extract may be the key players involved in increasing the bioavailability of paclitaxel .…”