Comparative pharmacokinetics of baicalin in plasma after oral administration of Huang-Lian-Jie-Du-Tang or pure baicalin in MCAO and sham-operated rats

Integrated pharmacokinetics of major bioactive components in MCAO rats after oral administration of Huang-Lian-Jie-Du-Tang

“…After the rats had been anesthetized with 10% chloral hydrate solution, the process of operation was taken as our previously reported studies (Zeng et al, 2010).…”

“…Berberine, palmatine, baicalin, baicalein and geniposide have been considered to be the major bioactive components in aqueous extract of HLJDT (Wang et al, 2004;Ma et al, 2005;Lu et al, 2007;Cui et al, 2009;Kim et al, 2009;Yin et al, 2010;Zeng et al, 2010). Among them, the alkaloids, such as berberine and palmatine have been used as phytochemical markers for the quality control of Rhizoma coptidis and Cortex phellodendri in the Chinese pharmacopoeia.…”

“…In our previous studies, simple and reliable methods were established to compare the concentrations of baicalin, geniposide and berberine respectively in MCAO and sham-operated rat plasma after oral administration of HLJDT extract and pure components (Zeng et al, 2009(Zeng et al, , 2010Pan et al, 2011). Our further study found out that although the function against anti-ischemia was connected with the contents of these index components in rat plasma, but different components produced various time bar and their concentrations varied greatly (Qian et al, 2011).…”

Effect of Gua Lou Gui Zhi decoction on focal cerebral ischemia-reperfusion injury through regulating the expression of excitatory amino acids and their receptors

“…A total of 80% of strokes are caused by arterial blockage and consequent ischemia and 20% are caused by hemorrhage. At present, stroke represents one of the three most dangerous diseases threatening human health (1). It has been reported that 70-80% of stroke survivors have a level of disability, particularly post-apoplectic limb spasm, which has become an increasingly serious social problem (2).…”

In Vivo Pharmacokinetics of Puerarin via Different Drug Administration Routes Based on Middle Cerebral Artery Occlusion Model

“…Significant rise were observed on AUC and C max , but there were no differences between two groups on T 1/2 . Zeng [20] also compared the pharmacokinetics of Geniposide in plasma after oral administration of Huang-Lian-Jie-Du-Tang decoction (a classic formula of Traditional Chinese Medicine) in MCAO and sham-operated rats, and came to an approximate result finally. For oral administration, there seems to be a rule: cerebral ischemia may increase the bioavailability of oral drugs.…”