In Vivo Pharmacokinetics of Puerarin via Different Drug Administration Routes Based on Middle Cerebral Artery Occlusion Model

Li, Pengyue; Bai, Jie; Dong, Boyu; Lu, Yang; Zhang, Shengwei; Guo, Shuang; Tan, Ning; Zhao, Mei‐Xin; Du, Shouying; Cao, Puning

doi:10.1007/s13318-016-0388-4

Cited by 11 publications

(7 citation statements)

References 20 publications

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“…At the end of the experiment, all the animals were euthanized, using urethane (Li et al, 2017). The hippocampus of the rats (n = 5) were dissected on an ice stage and preserved at −80 °C for oxidative stress markers and TNF-α analysis.…”

Section: Methodsmentioning

confidence: 99%

Combination antiretroviral therapy (cART)-induced hippocampal disorders: Highlights on therapeutic potential of Naringenin and Quercetin

et al. 2019

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HighlightsNaringenin and Quercetin decrease ROS and potentiate enzymatic antioxidant production in the hippocampus.cART induced marked cytoplasmic shrinkage and several pyknotic nuclei in the dentate gyrus and cornus ammonis region.Naringenin and Quercetin attenuates cART-induced upregulation of monoamine oxidase-B expression in neurons.Naringenin and Quercetin also ameliorates cART-induced spatial memory impairments.Naringenin and Quercetin acted as effective antioxidants in vivo against cART-induced neurotoxicity.

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Section: Methodsmentioning

confidence: 99%

Combination antiretroviral therapy (cART)-induced hippocampal disorders: Highlights on therapeutic potential of Naringenin and Quercetin

et al. 2019

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“…The main ingredients in the extract are flavonoids, and they may interact with each other in disposition and transportation through blood-brain barrier (BBB). So, pharmacokinetic parameters of the Extract group and the Puerarin group [7] were calculated by the non-compartmental method and compared with each other. For i.v.…”

Section: Pharmacokinetics Comparison Of Puerarin Between Puerarin Andmentioning

confidence: 99%

Coexisting flavonoids and administration route effect on pharmacokinetics of Puerarin in MCAO rats

Zhong

Yang

et al. 2020

Open Life Sciences

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AbstractA pharmacokinetic comparison was made to evaluate the influence from other components in the Radix Puerariae Extract on pharmacokinetic behavior of Puerarin. Samples of blood and brain were collected by microdialysis and determined by high-performance liquid chromatography–mass spectrometry (MS)/MS. Pharmacokinetic parameters were estimated from the concentration versus time data using non-compartmental methods. In addition, a comparative pharmacokinetic study of Puerarin in stroke rats was studied after administration of the Radix Puerariae Extract via different routes to find an effective way to deliver drug into brain. Obvious pharmacokinetic differences were also observed in comparison between the Puerarin group and the Radix Puerariae Extract group based on middle cerebral artery occlusion (MCAO) rats. The Cmax and area under the curve (AUC) of Puerarin in olfactory bulb of the Extract group significantly reduced when it was intravenously administered. However, the AUCs of Puerarin in plasma are 134.72 and 1707.02 mg/L min, via intranasal and intravenous administration of the Radix Puerariae Extract, respectively. The AUC of the intranasal group in brain is seven times higher than that of intravenous administration. Other ingredients in the Extract may affect the disposition of Puerarin and its transportation through the blood–brain barrier via intravenous administration. But intranasal administration is an effective route to deliver isoflavone-C-glycoside with poor hydrophilicity into brain.

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“…Puerarin could be widely distributed in areas of the brain after administration. Brain diseases such cerebral vascular ischemia could influence the brain-targeting of puerarin (Li et al., 2017; Kong et al., 2019). More puerarin was transported into brain with a shorter t 1/2 in middle cerebral artery occluasion rats model compared with control group via intranasal route (Li et al., 2017).…”

Section: Pharmacokinetics Of Puerarinmentioning

confidence: 99%

“…Brain diseases such cerebral vascular ischemia could influence the brain-targeting of puerarin (Li et al., 2017; Kong et al., 2019). More puerarin was transported into brain with a shorter t 1/2 in middle cerebral artery occluasion rats model compared with control group via intranasal route (Li et al., 2017). After intraperitoneal injection, AUC 0-120 min of puerarin in the embolic hippocampus was significantly higher than that in the normal hippocampus at 40 and 20 mg/kg.…”

Section: Pharmacokinetics Of Puerarinmentioning

confidence: 99%

Pharmacokinetics and drug delivery systems for puerarin, a bioactive flavone from traditional Chinese medicine

Zhang

2019

Drug Delivery

107

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Pueraria lobata (Willd.) Ohwi is a medicinal and edible homologous plant with a long history in China. Puerarin, the main component isolated from the root of Pueraria lobata, possesses a wide range of pharmacological properties. Daidzein and glucuronides are the main metabolites of puerarin and are excreted in the urine and feces. As active substrates of P-gp, multidrug resistance-associated protein and multiple metabolic enzymes, the pharmacokinetics of puerarin can be influenced by different pathological conditions and drug-drug interactions. Due to the poor water-solubility and liposolubility, the applications of puerarin are limited. So far, only puerarin injections and eye drops are on the market. Recent years, researches on improving the bioavailability of puerarin are developing rapidly, various nanotechnologies and preparation technologies including microemulsions and SMEDDS, dendrimers, nanoparticles and nanocrystals have been researched to improve the bioavailability of puerarin. In order to achieve biocompatibility and desired activity, more effective quality evaluations of nanocarriers are required. In this review, we summarize the pharmacokinetics and drug delivery systems of puerarin up to date.

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In Vivo Pharmacokinetics of Puerarin via Different Drug Administration Routes Based on Middle Cerebral Artery Occlusion Model

Cited by 11 publications

References 20 publications

Combination antiretroviral therapy (cART)-induced hippocampal disorders: Highlights on therapeutic potential of Naringenin and Quercetin

Combination antiretroviral therapy (cART)-induced hippocampal disorders: Highlights on therapeutic potential of Naringenin and Quercetin

Coexisting flavonoids and administration route effect on pharmacokinetics of Puerarin in MCAO rats

Pharmacokinetics and drug delivery systems for puerarin, a bioactive flavone from traditional Chinese medicine

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