2019
DOI: 10.1016/j.vaa.2018.09.042
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Comparative pharmacokinetics and a clinical laboratory evaluation of intravenous acetaminophen in Beagle and Galgo Español dogs

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Cited by 17 publications
(33 citation statements)
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“…In toxicosis of paracetamol, anorexia, weakness, tachypnoea, dyspnoea, cyanosis, icterus, hypothermia, lethargy, and vomiting have been observed in dogs [30] and cats [59]. In contrast to prior reports of such adverse effects, however, we found no changes in clinical laboratory variables or clinical signs 48 hours postoperative in the present study, results which align well with those reported by Serrano et al, [31].…”
Section: Carprofen Group Meloxicam Group Paracetamol Groupsupporting
confidence: 90%
See 1 more Smart Citation
“…In toxicosis of paracetamol, anorexia, weakness, tachypnoea, dyspnoea, cyanosis, icterus, hypothermia, lethargy, and vomiting have been observed in dogs [30] and cats [59]. In contrast to prior reports of such adverse effects, however, we found no changes in clinical laboratory variables or clinical signs 48 hours postoperative in the present study, results which align well with those reported by Serrano et al, [31].…”
Section: Carprofen Group Meloxicam Group Paracetamol Groupsupporting
confidence: 90%
“…There is significant evidence, however, that paracetamol is safe when prescribed at a therapeutic dose and for a limited period of time in dogs [31]. In part, the varying physiological interactions that paracetamol has may be in part to do with its potentiation of the analgesic effects of morphine [32] and tramadol in the management of postoperative pain in humans.…”
Section: Introductionmentioning
confidence: 99%
“…In toxicosis of paracetamol, anorexia, weakness, tachypnoea, dyspnoea, cyanosis, icterus, hypothermia, lethargy, and vomiting have been observed in dogs [30] and cats [36]. In contrast to prior reports of such adverse effects, however, we found no changes in clinical laboratory variables or clinical signs 48 hours postoperative in the present study, results which align well with those reported by Serrano et al , [31].…”
Section: Discussionsupporting
confidence: 90%
“…When various organs are cytologically examined in cases of toxicosis following paracetamol administration in overdose, splenic tissue hyperplasia, vacuolation, and degeneration of renal tubular epithelial cells, as well as multiple degrees of hypocellularity of the bone marrow, are often evident [30]. There is significant evidence, however, that paracetamol is safe when prescribed at a therapeutic dose and for a limited period of time in dogs [31].…”
Section: Introductionmentioning
confidence: 99%
“…Acetaminophen is one of the most used analgesic and antipyretic agent in human medicine and is licensed in Europe for oral route in dogs (combined with codeine phosphate) and pigs. It is used off‐label when administered intravenously and as a single therapeutic agent in nonfood producing animals (Serrano‐Rodríguez et al, 2019). Acetaminophen has a very small therapeutic window in cats and toxicity in this species occurs for doses closed to the therapeutic ones (10–40 mg/kg).…”
Section: Introductionmentioning
confidence: 99%