Comparative pharmacokinetic and renal clearance study of ceftiofur in cross breed Friesian and Buffalo calves

El-Gendy, A. A. M.; Tohamy, M.A.; Ismail, Magda M. F.

doi:10.21608/jvmr.2007.77896

Cited by 4 publications

(6 citation statements)

References 28 publications

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“…Cefotaxime was transferred from central to peripheral compartment at a slower rate (K12 =1.51 h -1 ) than its passage from peripheral compartment to central compartment (K21 = 1.02 h -1 ). These values were nearly similar to that reported for ceftiofur in buffalo calves (K12 = 1.557 h -1 ) and (K21 = 2.003 h -1 ) by El-Gendy et al, (2007) and cefquinome in chickens (K12 = 0.713 h -1 ) and (K21 = 1.06 h -1 ) by El-Sayed et al, 2015c).…”

Section: Discussionsupporting

confidence: 88%

“…On the other hand, this Vdss value was higher than those recorded for ceftriaxone in dogs (0.217 L/kg; Rebuelto et al, 2002); cefepime in calves and ewes (0.21 and 0.32 L/kg; Ismail, 2005a;Ismail, 2005c, respectively;ceftiofur in calves (0.134 L/kg;El-Gendy et al, 2007); ceftiofur in camel (0.13 L/kg; Goudah, 2007); ceftiofur in cow (0.178 L/kg; Tohamy, 2008); ceftriaxone in buffalo (0.36 L/kg;Gohil et al, 2009 ); cefpirome in cow calves (0.33 L/kg; Patel et al, 2013);ceftiofur in chickens (198.60 On the other hand, volume of distribution (Vdss) was shorter than that recorded in cefepime in rabbits (1.168 L/kg; Abd El-Aty et al, 2007); ceftriaxone in domestic cats (0.57 L/kg; Albarellos et al, 2007); cefepime in sheep (0.42 L/kg; Patel et al, 2010); cefoperazone in sheep (0.51 L/kg; Soni et al, 2012) and cefquinome in goats (0.51 L/kg; Dumka et al, 2013).…”

Section: Discussionmentioning

confidence: 57%

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Disposition Kinetics and Tissue Residues of Cefotaxime in Healthy and Experimentally Staphylococcus Aureus Infected Broiler Chickens

M.G¹,

Aboubakr²,

Rabea³

2018

Benha Veterinary Medical Journal

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The pharmacokinetic parameters of cefotaxime were studied following I.V. and I.M. (single & repeated) injection in normal and experimentally Staphylococcus aureus infected broiler chickens. Following a single intravenous injection of 25 mg cefotaxime/kg b.wt in normal chickens, cefotaxime could be detected therapeutically for 12 hours post intravenous injection with mean value 2.34 µg/ml. The serum concentrationtime curve of cefotaxime following intravenous injection showed that the drug obeyed two compartments open model with elimination half-life (t0.5(β) =3.11 h), volume of distribution (Vdss = 496.90 ml/kg) and total body clearance of the drug (CLtot= 137.63 ml/hr/kg). Following a single intramuscular injection of 25 mg/kg body weight cefotaxime in normal chickens, the peak plasma concentration (Cmax) was 19.54 µg/ml was achieved at a maximum time (Tmax) of 2.42 h. The intramuscular bioavailability of cefotaxime in normal chickens was 81.92 %. Intramuscular injection cefotaxime twice daily for five consecutive days in normal and Staphylococcus aureus infected chickens revealed a lower significant serum cefotaxime concentration after the first, third, fifth, seventh, ninth doses in Staphylococcus aureus infected chickens compared with normal chickens. Cefotaxime showed accumulative behavior in blood of chickens. After repeated intramuscular injection of 25 mg cefotaxime/kg b.wt every 12 h, cefotaxime was assayed in liver, kidney, lung, heart, breast muscle, thigh muscle and skin after 24, 48, 72, 96, 120 and 144 h post last dose. Drug concentrations in liver, kidney and lung were (23.17 ± 0.614) (15.51 ± 0.31), (16.69 ± 0.405) (10.94 ± 0.04) and (14.04 ± 0.52) (7.92 ± 0.395) µg/g in normal and Staphylococcus aureus infected chickens respectively 24 hours after the stoppage of drug medication. Cefotaxime was completely cleared from tissues at 144 and 120 hours after the stoppage of drug dosage in normal and Staphylococcus aureus infected chickens. Results of this study indicated that cefotaxime was useful for treatment of Staphylococcus aureus infections in chickens.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 57%

Disposition Kinetics and Tissue Residues of Cefotaxime in Healthy and Experimentally Staphylococcus Aureus Infected Broiler Chickens

M.G¹,

Aboubakr²,

Rabea³

2018

Benha Veterinary Medical Journal

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“…IV injection was equal to 5.700 h. This observation agreed with the data reported after IV administration of ceftiofur in cows and calves (t 0.5(β) ) =5.09, 5.05 h by(El- Gendy 2007 andTohamy, 2008), respectively.…”

supporting

confidence: 89%

Pharmacokinetics and Tissue residues of Ceftiofur in normal and Aeromonas Hydrophilia Infected Catfish (Clarias lazera)

El-Sayed

Farag²,

Elzoghby

2018

Benha Veterinary Medical Journal

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The pharmacokinetics of ceftiofur were studied in 78 catfish divided into 3 groups following IV and IM (single and repeated) administrations. Following a single IV injection of 5 mg/kg body weight of ceftiofur in normal catfish (Clarias lazera), serum concentration-time curve was best described by a two compartments open model with elimination half life (t0.5β), volume of distribution (Vdss) and total body clearance (CLtot) of 5.700 h, 229.71 ml/kg and 0.642 ml/kg/min, respectively. Following a single IM administration of 5 mg ceftiofur /kg body weight in normal catfish (Clarias lazera) , the peak serum concentration (Cmax) was 21.77 µg/ml, achieved at a maximum time (Tmax) of 2.15 h. The mean systemic bioavailability was 67.22%. The serum concentrations of ceftiofur following repeated IM administration of 5 mg/kg body weight once daily for five consecutive days in healthy and experimentally Aeromonas hydrophilia infected catfish (Clarias lazera) showed a lower significant values recorded in experimentally Aeromonas hydrophilia infected catfish (Clarias lazera) than in normal ones. Ceftiofur showed accumulative behavior in serum of fish. Results of this study indicated that ceftiofur was useful for treatment of Aeromonas hydrophilia infections in fish. Ceftiofur was assayed in serum, liver, kidney, dorsal muscle, abdominal muscle and skin after 24, 48, 72, 96 and 120 h from the last daily dose of 5mg ceftiofur/kg body weight for five days.. Ceftiofur could not be detected by spectrophotometer assay in all tested tissues in normal fish except in liver (four days), kidney (four days), and dorsal muscle (four days) post last administrations. Ceftiofur was completely cleared from serum and tissues at five days after the stoppage of drug dosage but in experimentally infected fish Ceftiofur could not be detected in all tested tissues except in liver (three days) and kidney (three days) post last administrations. Ceftiofur was completely cleared from all tissues at (four days) after the stoppage of drug dosage.

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“…Using this experimental design we found no significant difference between D 50 for the silt-loam and sandy soil types ( P = 0.93), and there was an expected dose response with D 50 being greater for 100 ppm compared to 50 ppm ( P = 0.044). Subsequent analyses used sandy soil and 50 ppm CFM in urine as a standard concentration (CFM concentrations in urine range from ∼7 to 165 ppm within 24 h of ceftiofur administration [21] ). The D 50 value of filter-sterilized urine alone with 50 ppm CFM was >110 days at both 23°C and 4°C indicating that abiotic hydrolysis of CFM was negligible during the course of these experiments.…”

Section: Resultsmentioning

confidence: 99%

“…Urine used in these experiments was collected from a single month-old male calf and was collected aseptically in sterile bottles both before and after administration of a single dose of ceftiofur sodium (Naxcel, 2.2 mg/kg body weight, intramuscular). El Gendy et al reported that after intramuscular administration of ceftiofur calves excreted most of the ceftiofur metabolites in the first 4 h post-injection and thus we collected urine up to 8 h post-injection [21] . The collected urine was filter-sterilized (0.22 µm pore size) and stored at –20°C until further use.…”

Section: Methodsmentioning

confidence: 99%

Urine from Treated Cattle Drives Selection for Cephalosporin Resistant Escherichia coli in Soil

et al. 2012

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The U.S. Food and Drug Administration recently issued new rules for using ceftiofur in food animals in part because of an increasing prevalence of enteric bacteria that are resistant to 3rd-generation cephalosporins. Parenteral ceftiofur treatment, however, has limited effects on enteric bacteria so we tested the hypothesis that excreted ceftiofur metabolites exert significant selection pressure for ceftiofur-resistant Escherichia coli in soil. Test matrices were prepared by mixing soil with bovine feces and adding urine containing ceftiofur metabolites (CFM) (0 ppm, ∼50 ppm and ∼100 ppm). Matrices were incubated at 23°C or 4°C for variable periods of time after which residual CFM was quantified using a bioassay. Bla CMY-2 plasmid-bearing ceftiofur resistant (cefR) E. coli and one-month old calves were used to study the selection effects of CFM and transmission of cefR bacteria from the environment back to animals. Our studies showed that urinary CFM (∼13 ppm final concentration) is biologically degraded in soil within 2.7 days at 23°C, but persists up to 23.3 days at 4°C. Even short-term persistence in soil provides a >1 log10 advantage to resistant E. coli populations, resulting in significantly prolonged persistence of these bacteria in the soil (∼two months). We further show that resistant strains readily colonize calves by contact with contaminated bedding and without antibiotic selection pressure. Ceftiofur metabolites in urine amplify resistant E. coli populations and, if applicable to field conditions, this effect is far more compelling than reported selection in vivo after parenteral administration of ceftiofur. Because ceftiofur degradation is temperature dependent, these compounds may accumulate during colder months and this could further enhance selection as seasonal temperatures increase. If cost-effective engineered solutions can be developed to limit ex vivo selection, this may limit proliferation for ceftiofur resistant enteric bacteria while preserving the ability to use this important antibiotic in food animal production.

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Comparative pharmacokinetic and renal clearance study of ceftiofur in cross breed Friesian and Buffalo calves

Cited by 4 publications

References 28 publications

Disposition Kinetics and Tissue Residues of Cefotaxime in Healthy and Experimentally Staphylococcus Aureus Infected Broiler Chickens

Disposition Kinetics and Tissue Residues of Cefotaxime in Healthy and Experimentally Staphylococcus Aureus Infected Broiler Chickens

Pharmacokinetics and Tissue residues of Ceftiofur in normal and Aeromonas Hydrophilia Infected Catfish (Clarias lazera)

Urine from Treated Cattle Drives Selection for Cephalosporin Resistant Escherichia coli in Soil

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