The present study was carried out to evaluate the effects of cisplatin on immunobiochemical parameters in rabbits and modulating by moringa leaves extract. A total of 20, healthy rabbits, 3-3.5 kg bwt were divided into 4 groups. Gp (1) control, Gp (2) received 5 mg/kg bwt IP cisplatin one dose every week for 4 weeks, Gp (3) received orally 200 mg of moringa olifera leaves extract/kg bwt daily for 4 weeks and Gp (4) received cisplatin and moringa leaves extract by same dose and periods. At 1 st , and 10 th days post administration 3 blood samples were taken from the ear vein for determination of some biochemical parameters. Cisplatin induced a significant decrease in WBCs, lymphocyte, phagocytic activity, killing %, total protein, albumin, total globulin, γ-globulin, HDL, GSH, SOD and CAT besides an insignificant decrease in basophil, α and β globulin coupled with a significant increase in AST, ALT ALP, urea, creatinine, cholesterol, triglycerides, LDL, VLDL, MDA and insignificant increase in neutrophil, monocyte and eosinophil at 1 st -day post-administration. Moringa leaves extract induced a significant increase in WBCs, neutrophil, monocyte, phagocytic activity, killing %, total protein, albumin, total globulin, γ-globulin, HDL GSH SOD, CAT and a significant decrease in cholesterol, triglycerides, LDL, VLDL, MDA beside non significant decrease in lymphocyte beside insignificant increase in basophil, eosinophil, α, β globulin AST, ALT, ALP, creatinine, urea at 1 st -day post-administration. Moringa leaves extract ameliorated the adverse effect of cisplatin by improving hematobiochemical and immuno-logical parameters and it returned to normal levels. It could be concluded that cisplatin induced adverse effects on biochemical parameters in rabbits. Using moringa leaves extract modulated the adverse effects of cisplatin. So, it is better to use antioxidants as moringa leaves extract with cisplatin

The pharmacokinetics of ceftiofur were studied in 78 catfish divided into 3 groups following IV and IM (single and repeated) administrations. Following a single IV injection of 5 mg/kg body weight of ceftiofur in normal catfish (Clarias lazera), serum concentration-time curve was best described by a two compartments open model with elimination half life (t0.5β), volume of distribution (Vdss) and total body clearance (CLtot) of 5.700 h, 229.71 ml/kg and 0.642 ml/kg/min, respectively. Following a single IM administration of 5 mg ceftiofur /kg body weight in normal catfish (Clarias lazera) , the peak serum concentration (Cmax) was 21.77 µg/ml, achieved at a maximum time (Tmax) of 2.15 h. The mean systemic bioavailability was 67.22%. The serum concentrations of ceftiofur following repeated IM administration of 5 mg/kg body weight once daily for five consecutive days in healthy and experimentally Aeromonas hydrophilia infected catfish (Clarias lazera) showed a lower significant values recorded in experimentally Aeromonas hydrophilia infected catfish (Clarias lazera) than in normal ones. Ceftiofur showed accumulative behavior in serum of fish. Results of this study indicated that ceftiofur was useful for treatment of Aeromonas hydrophilia infections in fish. Ceftiofur was assayed in serum, liver, kidney, dorsal muscle, abdominal muscle and skin after 24, 48, 72, 96 and 120 h from the last daily dose of 5mg ceftiofur/kg body weight for five days.. Ceftiofur could not be detected by spectrophotometer assay in all tested tissues in normal fish except in liver (four days), kidney (four days), and dorsal muscle (four days) post last administrations. Ceftiofur was completely cleared from serum and tissues at five days after the stoppage of drug dosage but in experimentally infected fish Ceftiofur could not be detected in all tested tissues except in liver (three days) and kidney (three days) post last administrations. Ceftiofur was completely cleared from all tissues at (four days) after the stoppage of drug dosage.